Parkinson's disease and diabetes mellitus: common mechanisms and treatment repurposing

• Published in: Neural regeneration research Vol. 17; no. 8; pp. 1652 - 1658
• Main Authors: Labandeira, Carmen, Fraga-Bau, Arturo, Arias Ron, David, Alvarez-Rodriguez, Elena, Vicente-Alba, Pablo, Lago-Garma, Javier, Rodriguez-Perez, Ana
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.08.2022; Medknow Publications & Media Pvt. Ltd; Department of Clinical Neurology,Hospital Alvaro Cunqueiro,University Hospital Complex,Vigo,Spain; Laboratory of Cellular and Molecular Neurobiology of Parkinson's Disease,Research Center for Molecular Medicine and Chronic Diseases(CIMUS),IDIS,University of Santiago de Compostela,Santiago de Compostela,Spain%Department of Clinical Neurology,Hospital Alvaro Cunqueiro,University Hospital Complex,Vigo,Spain%Department of Clinical Oncology,University Hospital Complex,Ourense,Spain%Department of Endocrinology,Hospital Meixoeiro, University Hospital Complex,Vigo,Spain%Laboratory of Cellular and Molecular Neurobiology of Parkinson's Disease,Research Center for Molecular Medicine and Chronic Diseases(CIMUS),IDIS,University of Santiago de Compostela,Santiago de Compostela,Spain; Networking Research Center on Neurodegenerative Diseases(CiberNed),Madrid,Spain; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: antidiabetic; diabetes mellitus; dopamine; exenatide; glucagon-like peptide-1; insulin; neurodegeneration; neuroinflammation; parkinson’s disease; repurposing; Antidiabetics; Diabetes; GLP-1 receptor agonists; Insulin resistance; Medical prognosis; Neurodegeneration; Parkinson's disease; Review; insulin; neuroinflammation; glucagon-like peptide-1; neurodegeneration; antidiabetic; diabetes mellitus; repurposing; dopamine; Parkinson’s disease; exenatide; Parkinson's disease
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.332122

In the last decade, attention has become greater to the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system, as insulin in the brain is implicated in neuronal survival, plasticity, oxidative stress and neuroinflammation. Diabetes mellitus and Parkinson...