Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice

• Published in: Neural regeneration research Vol. 17; no. 9; pp. 2007 - 2013
• Main Authors: Gong, Qiu-Yuan, Cai, Lin, Jing, Yao, Wang, Wei, Yang, Dian-Xu, Chen, Shi-Wen, Tian, Heng-Li
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.09.2022; Medknow Publications & Media Pvt. Ltd; Department of Neurosurgery,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai,China; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Alzheimer's disease; Apoptosis; Autophagy; autophagy; blood-brain barrier; cerebral edema; controlled cortical impact model; neuronal apoptosis; neuropharmacology; neuroprotection; tight junction protein; traumatic brain injury; urolithin a; Blood-brain barrier; Kinases; Traumatic brain injury; blood-brain barrier; autophagy; cerebral edema; tight junction protein; neuroprotection; neuropharmacology; traumatic brain injury; urolithin A; controlled cortical impact model; neuronal apoptosis

Urolithin A (UA) is a natural metabolite produced from polyphenolics in foods such as pomegranates, berries, and nuts. UA is neuroprotective against Parkinson's disease, Alzheimer's disease, and cerebral hemorrhage. However, its effect against traumatic brain injury remains unknown. In thi...