Association of hypometabolism and amyloid levels in aging, normal subjects

• Published in: Neurology Vol. 82; no. 22; p. 1959
• Main Authors: Lowe, Val J, Weigand, Stephen D, Senjem, Matthew L, Vemuri, Prashanthi, Jordan, Lennon, Kantarci, Kejal, Boeve, Bradley, Jack, Jr, Clifford R, Knopman, David, Petersen, Ronald C
• Format: Journal Article
• Language: English
• Published: United States 03.06.2014
• Subjects: Aged; Aged, 80 and over; Aging - metabolism; Amyloid - metabolism; Aniline Compounds; Apolipoprotein E4 - genetics; Cerebral Cortex - metabolism; Cross-Sectional Studies; Female; Fluorodeoxyglucose F18; Humans; Male; Multimodal Imaging - instrumentation; Multimodal Imaging - methods; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles

We evaluated the relationship of amyloid, seen on Pittsburgh compound B (PiB)-PET, and metabolism, seen on [(18)F]-fluorodeoxyglucose (FDG)-PET, in normal subjects to better understand pathogenesis and biomarker selection in presymptomatic subjects. Normal participants (aged 70-95 years; 600 with Pi...