PRECREST: a phase II prevention and biomarker trial of creatine in at-risk Huntington disease - Rosas, Herminia D; Doros, Gheorghe; Gevorkian, Sona; Malarick, Keith; Reuter, Martin; Coutu, Jean-Philippe; Triggs, Tyler D; Wilkens, Paul J; Matson, Wayne; Salat, David H; Hersch, Steven M (Neurology, 2014)
Keywords: Adult; Atrophy; Biomarkers - blood; Brain - drug effects; Brain - pathology; Cognition Disorders - blood; Cognition Disorders - pathology; Cognition Disorders - prevention & control; Creatine - administration & dosage; Creatine - adverse effects; Creatine - pharmacology; Cross-Over Studies; Diffusion Magnetic Resonance Imaging; Double-Blind Method; Feasibility Studies; Genetic Predisposition to Disease; Humans; Huntington Disease - blood; Huntington Disease - pathology; Huntington Disease - prevention & control; Prodromal Symptoms; Time Factors; Treatment Outcome