The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

• Published in: British journal of pharmacology Vol. 146; no. 8; pp. 1041 - 1059
• Main Authors: Gaeta, Alessandra, Hider, Robert C
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2005; Nature Publishing
• Subjects: alpha-Synuclein - metabolism; Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Amyloid beta-Peptides - metabolism; Animals; Aβ‐amyloid; Biological and medical sciences; Chelating Agents - pharmacology; chelation therapy; copper; Copper - metabolism; Humans; Ions; iron; Iron - metabolism; Manganese - metabolism; Medical sciences; Metals - metabolism; Neurodegeneration; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - physiopathology; Oxidative Stress; Parkinson Disease - drug therapy; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; Pharmacology. Drug treatments; Prion Diseases - drug therapy; Prion Diseases - metabolism; Prion Diseases - physiopathology; prion protein; Prions - metabolism; protein aggregation; Proteins - metabolism; Review; α‐synuclein; Oxidative stress; Metal ion; chelation therapy; Iron; Aggregation; Treatment; Neurodegeneration; protein aggregation; Amyloid; Degeneration; Aβ-amyloid; Copper; Prion protein; α-synuclein

The variety of factors and events involved in neurodegeneration renders the subject a major challenge. Neurodegenerative disorders include a number of different pathological conditions, which share similar critical metabolic processes, such as protein aggregation and oxidative stress, both of which...