Renin–angiotensin system inhibitors positively impact on multiple aging regulatory pathways: Could they be used to protect against human aging? - Cavanagh, Elena M. V.; Inserra, Felipe; Ferder, León (Physiological reports, 2024)
Keywords: 1-Phosphatidylinositol 3-kinase; Age; Aging; Aging - drug effects; Aging - metabolism; Aging - physiology; Angiotensin; Angiotensin Receptor Antagonists - pharmacology; Angiotensin Receptor Antagonists - therapeutic use; Angiotensin-converting enzyme inhibitors; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Animals; antiaging; Blood pressure; Clinical trials; Down-regulation; Enzymes; Growth hormones; Humans; Hypertension; Insulin-like growth factor I; Insulin-like growth factors; Klotho protein; Life span; MAP kinase; Metabolism; Metabolites; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; NF-κB protein; Nitric oxide; Peptides; Peptidyl-dipeptidase A; Phosphatase; Protein kinase C; Proteins; RAS‐blockers; Renin; Renin-Angiotensin System - drug effects; Review; Reviews; Signal transduction; Signal Transduction - drug effects; TOR protein; Vitamin D; Wnt protein; antiaging; mitochondria; RAS‐blockers