Carotid chemoreceptor modulation of sympathetic vasoconstrictor outflow during exercise in healthy humans

• Published in: The Journal of physiology Vol. 586; no. 6; pp. 1743 - 1754
• Main Authors: Stickland, Michael K., Morgan, Barbara J., Dempsey, Jerome A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK The Physiological Society 15.03.2008; Blackwell Publishing Ltd; Blackwell Science Inc
• Subjects: Adult; Carotid Body - physiology; Chemoreceptor Cells - physiology; Exercise Test; Humans; Integrative; Male; Muscle, Skeletal - blood supply; Muscle, Skeletal - physiology; Physical Endurance - physiology; Physical Exertion - physiology; Sympathetic Nervous System - physiology; Vasoconstriction - physiology

Recently, we have shown that specific, transient carotid chemoreceptor (CC) inhibition in exercising dogs causes vasodilatation in limb muscle. The purpose of the present investigation was to determine if CC suppression reduces muscle sympathetic nerve activity (MSNA) in exercising humans. Healthy s...