具有隐匿型PML-RARα融合基因的罕见急性早幼粒细胞白血病一例报告并文献复习
急性早幼粒细胞白血病（APL）是急性髓系白血病的一个特殊亚型，其特异性的细胞遗传学异常为t（15；17）（q22；q12），15号染色体上的PML基因和17号染色体上的维甲酸受体（RARα）基因融合，形成PML-RARα融合基因，其编码PML-RARα的蛋白，可以阻止细胞分化，从而导致骨髓中堆积大量的异常早幼粒细胞。...
Saved in:
| Published in | 中华血液学杂志 Vol. 37; no. 11; pp. 1001 - 1002 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
100191,北京大学第三医院血液科
2016
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-2727 |
| DOI | 10.3760/cma.j.issn.0253-2727.2016.11.016 |
Cover
| Abstract | 急性早幼粒细胞白血病（APL）是急性髓系白血病的一个特殊亚型，其特异性的细胞遗传学异常为t（15；17）（q22；q12），15号染色体上的PML基因和17号染色体上的维甲酸受体（RARα）基因融合，形成PML-RARα融合基因，其编码PML-RARα的蛋白，可以阻止细胞分化，从而导致骨髓中堆积大量的异常早幼粒细胞。 |
|---|---|
| AbstractList | 急性早幼粒细胞白血病（APL）是急性髓系白血病的一个特殊亚型，其特异性的细胞遗传学异常为t（15；17）（q22；q12），15号染色体上的PML基因和17号染色体上的维甲酸受体（RARα）基因融合，形成PML-RARα融合基因，其编码PML-RARα的蛋白，可以阻止细胞分化，从而导致骨髓中堆积大量的异常早幼粒细胞。 @@ |
| Author | 王艳芳 刘佳 董菲 田磊 王晶 郤连永 克晓燕 |
| AuthorAffiliation | 北京大学第三医院血液科,100191 |
| AuthorAffiliation_xml | – name: 100191,北京大学第三医院血液科 |
| Author_FL | Ke Xiaoyan Tian Lei Xi Lianyong Liu Jia Dong Fei Wang Yanfang Wang Jing |
| Author_FL_xml | – sequence: 1 fullname: Wang Yanfang – sequence: 2 fullname: Liu Jia – sequence: 3 fullname: Dong Fei – sequence: 4 fullname: Tian Lei – sequence: 5 fullname: Wang Jing – sequence: 6 fullname: Xi Lianyong – sequence: 7 fullname: Ke Xiaoyan |
| Author_xml | – sequence: 1 fullname: 王艳芳 刘佳 董菲 田磊 王晶 郤连永 克晓燕 |
| BookMark | eNo9kEtLAlEYhs_CIK3-RItoM9M5czszS5FuYBTiXs6MZ7yQYzlE2soou3gBC0qyMINE2gS1qKysf9Cv8MzYv2jCaPM98L0P3wdvAPisrEUBmEWQF7EC54wM4dN8yrYtHgqyyAlYwLwAkcIjxHvwAf__fhwEbDsNoeTlkh-YrPTsXB1_N-us-slalbWVMBcJRr4ehq0aqx-x61d22Xab-27_bNjddYodp9h1Gnes9-4-nrpvB8O9lnvRH94U3UZp8FIcfFSccoedlFnvyTk_dKv37LY26LUnwZhJ1m069ccJEF2Yj4aWuPDq4nIoGOYMWVU4UxV0bKqQUIwkKCoKpppoykQVBSkuQcVQCIE0TnVJ1TGV9bisI0xUDUmUIghlcQLMjM5uE8skViKWzm7lLO9hbCeZL-R_K0HIG544PRKNZNZKbKY8dSOXypBcIaZgKGsShpr4A7wViTE |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3760/cma.j.issn.0253-2727.2016.11.016 |
| DatabaseName | 维普_期刊 中文科技期刊数据库-CALIS站点 中文科技期刊数据库-7.0平台 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | The study of one ease of APL with rare cryptic PML- RARα fusion gene and the literatures review |
| DocumentTitle_FL | The study of one case of APL with rare cryptic PML-RARα fusion gene and the literatures review |
| EndPage | 1002 |
| ExternalDocumentID | zhxyx201611016 670594709 |
| GroupedDBID | --- -05 2B. 2C~ 2RA 92F 92I 92L ACGFS ALMA_UNASSIGNED_HOLDINGS CCEZO CIEJG CQIGP CW9 F5P OK1 RPM TCJ TGQ U1G U5O W91 ~WA 4A8 93N ABJNI PSX |
| ID | FETCH-LOGICAL-c586-f82b7f80ae71403667e93f5a8324d406c6aa0edeb48b7e5bd5b17a8914ee10053 |
| ISSN | 0253-2727 |
| IngestDate | Thu May 29 04:00:17 EDT 2025 Wed Feb 14 10:08:07 EST 2024 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 11 |
| Keywords | @@ |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c586-f82b7f80ae71403667e93f5a8324d406c6aa0edeb48b7e5bd5b17a8914ee10053 |
| Notes | Wang Yan- fang, Liu Jia, Dong Fei, Tian Lei, Wang ,ling, Xi Lianyong, Ke Xiaoyan （Department of Hematology, Peking University Third Hospital, Beijing 100191, China.） 12-1090/R |
| PageCount | 2 |
| ParticipantIDs | wanfang_journals_zhxyx201611016 chongqing_primary_670594709 |
| PublicationCentury | 2000 |
| PublicationDate | 2016 |
| PublicationDateYYYYMMDD | 2016-01-01 |
| PublicationDate_xml | – year: 2016 text: 2016 |
| PublicationDecade | 2010 |
| PublicationTitle | 中华血液学杂志 |
| PublicationTitleAlternate | Chinese Journal of Hematology |
| PublicationTitle_FL | Chinese Journal of Hematology |
| PublicationYear | 2016 |
| Publisher | 100191,北京大学第三医院血液科 |
| Publisher_xml | – name: 100191,北京大学第三医院血液科 |
| SSID | ssj0042014 ssib051368330 ssib017477332 ssib001103535 ssib058574913 |
| Score | 2.0523698 |
| Snippet | 急性早幼粒细胞白血病（APL）是急性髓系白血病的一个特殊亚型，其特异性的细胞遗传学异常为t（15；17）（q22；q12），15号染色体上的PML基因和17号染色体上的维甲酸受体（RARα）基因融合，形成PML-RARα融合基因，其编码PML-RARα的蛋白，可以阻止细胞分化，从而导致骨髓中堆积大量的异常早幼粒细胞。 @@ |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 1001 |
| SubjectTerms | 15号染色体 17号染色体 PML-RARα融合基因 急性早幼粒细胞白血病 急性髓系白血病 文献复习 细胞遗传学异常 隐匿型 |
| Title | 具有隐匿型PML-RARα融合基因的罕见急性早幼粒细胞白血病一例报告并文献复习 |
| URI | http://lib.cqvip.com/qk/93752X/201611/670594709.html https://d.wanfangdata.com.cn/periodical/zhxyx201611016 |
| Volume | 37 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LaxRBEB6SCOJFFBVjfORgg5dZZ2anp7uPPbsTghiRECG3ZV6bILjxkUDMaUXjIw-IggajxAiG4EXQgxo1-g_8AZ4zu-u_sKpndrMJgaiXoeiq_qq6anq6pne6VtPOGoEwA2YYOhdGqNsRPAeDOKZ6XLYDETMRMVVSaOCS03_FvjBMhzs6f7V9tTQxHuTCqV3PlfxPVKEN4oqnZP8hsi1QaAAa4gtXiDBc_yrGxKOEU-Iy4jlEFAgXxBNESCIMxSoQtw8J4RHuXh64qA_KQVLwiGsSj6vWomIbhHNF9BFXKsIlEiAYYnEbCbdIBMVekkHyifq4QSRtEqkFjEiB3V1B3ILqZRFhKcIl3MHuPI96EVkgJgKaiIAtDAfj2cTlqgUItFupkEoXGGYinalwlFLgMuwOo5UesqStxmWjjDTas-8MXKpRgwz32gxwEBAMRoQikSk4yKgW8KNordhKW2oaR5-7eUVIILZEKPpUcKWyuI3DcRQy7QMOt9phBUgrZwCfy_YtmfSsqJo-WNAKIKxCFmRwHGoBHxWy8WM8WsNg2I6s1LOieWu46mYBH1m7eYEhSPoXZ9lCYdG8brG0xkJzVUtL6TRnr9m2RqGRbfkO1uDdbS3Fr6VgAoTX_NxVpSfX0oNfRDo5LH5r7ihjrhKjqdHJ25MoYuLWUKe2z2LMpDt20oCXp1upOjXzDs9vvcrCWyyz1S_oaVZlA54qBde0Yb92LjPy_F4mYtmU0bHKyA1IBtXZvErZr4y0pZFDh7SD2ftfr0wn82GtY2r0iFZOpj_VXj76vbSQzP1IlmezqfrzfWN5Pll4mLz6krxYqS_dq288bazdqVVXa9W12uLbZP1b_cOT-tf7jbvL9ecbjdfV-uL05ufq5vfZ2sxq8ngmWf9Ye_agPvcueTO_ub5yVBvq84YK_Xr2Byh6SLmjl7kVsDI3_FhV1XQcFot8mfqwCNsRJOKh4_tGHMWBzQMW0yCigcl8Lkw7jk1cXY9pXZWxSnxc643KLKKUxgY8mO0wiLkdWhbI-aHvW3EQdWs9LReVrqd1bkoOw2JOzBDd2pnMaaXs6XertD3IJ_aU6NEOIJ3uXp7UusZvTsSnIJ8fD06rG-MPVDrH4w |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%85%B7%E6%9C%89%E9%9A%90%E5%8C%BF%E5%9E%8BPML-RAR%CE%B1%E8%9E%8D%E5%90%88%E5%9F%BA%E5%9B%A0%E7%9A%84%E7%BD%95%E8%A7%81%E6%80%A5%E6%80%A7%E6%97%A9%E5%B9%BC%E7%B2%92%E7%BB%86%E8%83%9E%E7%99%BD%E8%A1%80%E7%97%85%E4%B8%80%E4%BE%8B%E6%8A%A5%E5%91%8A%E5%B9%B6%E6%96%87%E7%8C%AE%E5%A4%8D%E4%B9%A0&rft.jtitle=%E4%B8%AD%E5%8D%8E%E8%A1%80%E6%B6%B2%E5%AD%A6%E6%9D%82%E5%BF%97&rft.au=%E7%8E%8B%E8%89%B3%E8%8A%B3&rft.au=%E5%88%98%E4%BD%B3&rft.au=%E8%91%A3%E8%8F%B2&rft.au=%E7%94%B0%E7%A3%8A&rft.date=2016&rft.pub=100191%2C%E5%8C%97%E4%BA%AC%E5%A4%A7%E5%AD%A6%E7%AC%AC%E4%B8%89%E5%8C%BB%E9%99%A2%E8%A1%80%E6%B6%B2%E7%A7%91&rft.issn=0253-2727&rft.volume=37&rft.issue=11&rft.spage=1001&rft.epage=1002&rft_id=info:doi/10.3760%2Fcma.j.issn.0253-2727.2016.11.016&rft.externalDocID=zhxyx201611016 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F93752X%2F93752X.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzhxyx%2Fzhxyx.jpg |