Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death

• Published in: Oncogene Vol. 35; no. 40; pp. 5282 - 5294
• Main Authors: Bhattacharya, S, Chalk, A M, Ng, A J M, Martin, T J, Zannettino, A C, Purton, L E, Lu, J, Baker, E K, Walkley, C R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.10.2016; Nature Publishing Group
• Subjects: 13/2; 13/31; 13/89; 38/39; 38/90; 631/67/1798; 64/60; 82/80; Analysis; Animal models; Animals; Apoptosis; Apoptosis - genetics; Biochemistry; Bone cancer; Cell Biology; Cell death; Cell Differentiation - genetics; Cell fate; Cell Line, Tumor; Cell proliferation; Cell Proliferation - genetics; Computer applications; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Genetic engineering; Genetically modified organisms; Human Genetics; Humans; Internal Medicine; Medicine; Medicine & Public Health; Metastases; Mice; MicroRNA; MicroRNAs; MicroRNAs - biosynthesis; MicroRNAs - genetics; miRNA; Necroptosis; Oncology; original-article; Osteoblasts; Osteosarcoma; Osteosarcoma - genetics; Osteosarcoma - pathology; Protein-serine/threonine kinase; Receptor-Interacting Protein Serine-Threonine Kinases - genetics; Sarcoma; siRNA; Tumor cells; Wildlife conservation; Young adults

Osteosarcoma (OS) is the most common cancer of bone and the 5th leading cause of cancer-related death in young adults. Currently, 5-year survival rates have plateaued at ~70% for patients with localized disease. Those with disseminated disease have an ~20% 5-year survival. An improved understanding...