Time for new reference values for ventilatory lung function
Objective The anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or not the commonly used reference values of the European Community (ECCS) for lung function, may still be accepted today. Measured values for eld...
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| Published in | European journal of medical research Vol. 14; no. Suppl 4; pp. 140 - 146 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
07.12.2009
BioMed Central Ltd BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2047-783X 0949-2321 2047-783X |
| DOI | 10.1186/2047-783X-14-S4-140 |
Cover
| Abstract | Objective
The anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or not the commonly used reference values of the European Community (ECCS) for lung function, may still be accepted today. Measured values for elderly are classified by extrapolation beyond the range of reference equations.
Materials and methods
Lung function was examined by pneumotachography for recording static lung volumes and flow-volume-curves in 257 asymptomatic non smoking males, aged 20-90 years. Results were compared to the reference values of ECCS, SAPALDIA, LuftiBus, and NHANES.
Results
For analysis age and height dependence of investigated respiratory parameters (VC, FVC, FEV
1
, FEV
1
%FVC, PEF, MEF
75,50,25
) can for simplicity be described by linear functions (y = a · height(H)-b · age (A)+c). The forced expiratory volume in one second, FEV
1
, was calculated by FEV
1
= 0.0432 · H-0.0347 · A-2.114; where H - height, A - age; r = 0.78. Mean FEV
1
for younger subjects was found to be 106.1 ± 11.2% of the ECCS reference values and 97.8 ± 11.7% in older subjects. For all parameters investigated linear regressions on age were steeper than described by the ECCS reference values. The regression of lung function to height largely follows the ECCS prescriptions.
Summary
Bochum lung function values of healthy subjects showed a steeper age descent compared to the reference values of the ECCS. The alternatively discussed reference values of the SAPALDIA-, NHANES- or LuftiBus-Study are higher, but do not cover all necessary parameters and/or the age range. A multi centre study for contemporary reference values is recommended. |
|---|---|
| AbstractList | Objective
The anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or not the commonly used reference values of the European Community (ECCS) for lung function, may still be accepted today. Measured values for elderly are classified by extrapolation beyond the range of reference equations.
Materials and methods
Lung function was examined by pneumotachography for recording static lung volumes and flow-volume-curves in 257 asymptomatic non smoking males, aged 20-90 years. Results were compared to the reference values of ECCS, SAPALDIA, LuftiBus, and NHANES.
Results
For analysis age and height dependence of investigated respiratory parameters (VC, FVC, FEV
1
, FEV
1
%FVC, PEF, MEF
75,50,25
) can for simplicity be described by linear functions (y = a · height(H)-b · age (A)+c). The forced expiratory volume in one second, FEV
1
, was calculated by FEV
1
= 0.0432 · H-0.0347 · A-2.114; where H - height, A - age; r = 0.78. Mean FEV
1
for younger subjects was found to be 106.1 ± 11.2% of the ECCS reference values and 97.8 ± 11.7% in older subjects. For all parameters investigated linear regressions on age were steeper than described by the ECCS reference values. The regression of lung function to height largely follows the ECCS prescriptions.
Summary
Bochum lung function values of healthy subjects showed a steeper age descent compared to the reference values of the ECCS. The alternatively discussed reference values of the SAPALDIA-, NHANES- or LuftiBus-Study are higher, but do not cover all necessary parameters and/or the age range. A multi centre study for contemporary reference values is recommended. Objective The anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or not the commonly used reference values of the European Community (ECCS) for lung function, may still be accepted today. Measured values for elderly are classified by extrapolation beyond the range of reference equations. Materials and methods Lung function was examined by pneumotachography for recording static lung volumes and flow-volume-curves in 257 asymptomatic non smoking males, aged 20-90 years. Results were compared to the reference values of ECCS, SAPALDIA, LuftiBus, and NHANES. Results For analysis age and height dependence of investigated respiratory parameters (VC, FVC, FEV.sub.1, FEV.sub.1 %FVC, PEF, MEF.sub.75,50,25) can for simplicity be described by linear functions (y = a * height(H)-b * age (A)+c). The forced expiratory volume in one second, FEV.sub.1, was calculated by FEV.sub.1 = 0.0432 * H-0.0347 * A-2.114; where H - height, A - age; r = 0.78. Mean FEV.sub.1 for younger subjects was found to be 106.1 [+ or -] 11.2% of the ECCS reference values and 97.8 [+ or -] 11.7% in older subjects. For all parameters investigated linear regressions on age were steeper than described by the ECCS reference values. The regression of lung function to height largely follows the ECCS prescriptions. Summary Bochum lung function values of healthy subjects showed a steeper age descent compared to the reference values of the ECCS. The alternatively discussed reference values of the SAPALDIA-, NHANES- or LuftiBus-Study are higher, but do not cover all necessary parameters and/or the age range. A multi centre study for contemporary reference values is recommended. Keywords: lung function, reference values, elderly males, spirometry, forced expiration The anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or not the commonly used reference values of the European Community (ECCS) for lung function, may still be accepted today. Measured values for elderly are classified by extrapolation beyond the range of reference equations.OBJECTIVEThe anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or not the commonly used reference values of the European Community (ECCS) for lung function, may still be accepted today. Measured values for elderly are classified by extrapolation beyond the range of reference equations.Lung function was examined by pneumotachography for recording static lung volumes and flow-volume-curves in 257 asymptomatic non smoking males, aged 20-90 years. Results were compared to the reference values of ECCS, SAPALDIA, LuftiBus, and NHANES.MATERIAL AND METHODSLung function was examined by pneumotachography for recording static lung volumes and flow-volume-curves in 257 asymptomatic non smoking males, aged 20-90 years. Results were compared to the reference values of ECCS, SAPALDIA, LuftiBus, and NHANES.For analysis age and height dependence of investigated respiratory parameters (VC, FVC, FEV(1), FEV(1) %FVC, PEF, MEF(75,50,25)) can for simplicity be described by linear functions (y = a . height(H)-b . age (A)+c). The forced expiratory volume in one second, FEV(1), was calculated by FEV(1) = 0.0432 . H-0.0347 . A -2.114; where H - height, A - age; r = 0.78. Mean FEV(1) for younger subjects was found to be 106.1 +/- 11.2% of the ECCS reference values and 97.8 +/- 11.7% in older subjects. For all parameters investigated linear regressions on age were steeper than described by the ECCS reference values. The regression of lung function to height largely follows the ECCS prescriptions.RESULTSFor analysis age and height dependence of investigated respiratory parameters (VC, FVC, FEV(1), FEV(1) %FVC, PEF, MEF(75,50,25)) can for simplicity be described by linear functions (y = a . height(H)-b . age (A)+c). The forced expiratory volume in one second, FEV(1), was calculated by FEV(1) = 0.0432 . H-0.0347 . A -2.114; where H - height, A - age; r = 0.78. Mean FEV(1) for younger subjects was found to be 106.1 +/- 11.2% of the ECCS reference values and 97.8 +/- 11.7% in older subjects. For all parameters investigated linear regressions on age were steeper than described by the ECCS reference values. The regression of lung function to height largely follows the ECCS prescriptions.Bochum lung function values of healthy subjects showed a steeper age descent compared to the reference values of the ECCS. The alternatively discussed reference values of the SAPALDIA-, NHANES- or LuftiBus-Study are higher, but do not cover all necessary parameters and/or the age range. A multi centre study for contemporary reference values is recommended.SUMMARYBochum lung function values of healthy subjects showed a steeper age descent compared to the reference values of the ECCS. The alternatively discussed reference values of the SAPALDIA-, NHANES- or LuftiBus-Study are higher, but do not cover all necessary parameters and/or the age range. A multi centre study for contemporary reference values is recommended. Abstract Objective The anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or not the commonly used reference values of the European Community (ECCS) for lung function, may still be accepted today. Measured values for elderly are classified by extrapolation beyond the range of reference equations. Materials and methods Lung function was examined by pneumotachography for recording static lung volumes and flow-volume-curves in 257 asymptomatic non smoking males, aged 20-90 years. Results were compared to the reference values of ECCS, SAPALDIA, LuftiBus, and NHANES. Results For analysis age and height dependence of investigated respiratory parameters (VC, FVC, FEV1, FEV1 %FVC, PEF, MEF75,50,25) can for simplicity be described by linear functions (y = a · height(H)-b · age (A)+c). The forced expiratory volume in one second, FEV1, was calculated by FEV1 = 0.0432 · H-0.0347 · A-2.114; where H - height, A - age; r = 0.78. Mean FEV1 for younger subjects was found to be 106.1 ± 11.2% of the ECCS reference values and 97.8 ± 11.7% in older subjects. For all parameters investigated linear regressions on age were steeper than described by the ECCS reference values. The regression of lung function to height largely follows the ECCS prescriptions. Summary Bochum lung function values of healthy subjects showed a steeper age descent compared to the reference values of the ECCS. The alternatively discussed reference values of the SAPALDIA-, NHANES- or LuftiBus-Study are higher, but do not cover all necessary parameters and/or the age range. A multi centre study for contemporary reference values is recommended. The anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or not the commonly used reference values of the European Community (ECCS) for lung function, may still be accepted today. Measured values for elderly are classified by extrapolation beyond the range of reference equations. Lung function was examined by pneumotachography for recording static lung volumes and flow-volume-curves in 257 asymptomatic non smoking males, aged 20-90 years. Results were compared to the reference values of ECCS, SAPALDIA, LuftiBus, and NHANES. For analysis age and height dependence of investigated respiratory parameters (VC, FVC, FEV(1), FEV(1) %FVC, PEF, MEF(75,50,25)) can for simplicity be described by linear functions (y = a . height(H)-b . age (A)+c). The forced expiratory volume in one second, FEV(1), was calculated by FEV(1) = 0.0432 . H-0.0347 . A -2.114; where H - height, A - age; r = 0.78. Mean FEV(1) for younger subjects was found to be 106.1 +/- 11.2% of the ECCS reference values and 97.8 +/- 11.7% in older subjects. For all parameters investigated linear regressions on age were steeper than described by the ECCS reference values. The regression of lung function to height largely follows the ECCS prescriptions. Bochum lung function values of healthy subjects showed a steeper age descent compared to the reference values of the ECCS. The alternatively discussed reference values of the SAPALDIA-, NHANES- or LuftiBus-Study are higher, but do not cover all necessary parameters and/or the age range. A multi centre study for contemporary reference values is recommended. |
| Audience | Academic |
| Author | Marek, W Kotschy-Lang, N Marek, E Kohlhäufl, M Mückenhoff, K Smith, H-J Degens, P |
| AuthorAffiliation | 6 Klinik Schillerhöhe, Center for Pulmonolgy and Thoracic Surgery, Academic Teaching Hospital, University of Tubingen, Stuttgart-Gerlingen, Germany 1 Institute of Occupational Physiology, Augusta-Kranken-Anstalt, Bochum 4 Forschungsinstitut für Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung, Bochum 2 Institute of Physiology, Ruhr-Universität Bochum 5 Berufsgenossenschaftliche Klinik für Berufskrankheiten Falkenstein 3 Cardinal Health, Höchberg |
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| Author_xml | – sequence: 1 givenname: W surname: Marek fullname: Marek, W email: Wolfgang.Marek@ruhr-uni-bochum.de organization: Institute of Occupational Physiology, Augusta-Kranken-Anstalt – sequence: 2 givenname: E surname: Marek fullname: Marek, E organization: Institute of Occupational Physiology, Augusta-Kranken-Anstalt – sequence: 3 givenname: K surname: Mückenhoff fullname: Mückenhoff, K organization: Institute of Physiology, Ruhr-Universität – sequence: 4 givenname: H-J surname: Smith fullname: Smith, H-J organization: Cardinal Health – sequence: 5 givenname: P surname: Degens fullname: Degens, P organization: Forschungsinstitut für Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung – sequence: 6 givenname: N surname: Kotschy-Lang fullname: Kotschy-Lang, N organization: Berufsgenossenschaftliche Klinik für Berufskrankheiten Falkenstein – sequence: 7 givenname: M surname: Kohlhäufl fullname: Kohlhäufl, M organization: Klinik Schillerhöhe, Center for Pulmonolgy and Thoracic Surgery, Academic Teaching Hospital, University of Tubingen |
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The anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or... The anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or not the... Objective The anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or... Abstract Objective The anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises... |
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| SubjectTerms | Adult Age Factors Aged Aged, 80 and over Biomedicine Body Height elderly males forced expiration Forced Expiratory Volume Humans Infectious Diseases Internal Medicine Lung - physiology lung function Male Medicine Medicine & Public Health Middle Aged Oncology Reference Values spirometry Surgery |
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| Title | Time for new reference values for ventilatory lung function |
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