MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 35; pp. 12885 - 12890
• Main Authors: Pichiorri, Flavia, Suh, Sung-Suk, Ladetto, Marco, Kuehl, Michael, Palumbo, Tiziana, Drandi, Daniela, Taccioli, Cristian, Zanesi, Nicola, Alder, Hansjuerg, Hagan, John P, Munker, Reinhold, Volinia, Stefano, Boccadoro, Mario, Garzon, Ramiro, Palumbo, Antonio, Aqeilan, Rami I, Croce, Carlo M
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 02.09.2008; National Acad Sciences
• Subjects: Animals; antagonists; Apoptosis Regulatory Proteins - metabolism; Base Sequence; Bcl-2-Like Protein 11; Biological Sciences; Bone marrow; Cell growth; Cell Line, Tumor; Cell lines; Cells; Gene expression; Gene Expression Profiling; gene expression regulation; Gene Expression Regulation, Neoplastic; genes; Genes, Neoplasm; Health; Humans; interleukin-6; Membrane Proteins - metabolism; messenger RNA; Mice; Mice, Nude; microarray technology; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Molecular Sequence Data; Monoclonal Gammopathy of Undetermined Significance; Multiple myeloma; Multiple Myeloma - genetics; Multiple Myeloma - pathology; myeloma; non-coding RNA; Oligonucleotides; p300-CBP Transcription Factors - metabolism; pathogenesis; Pathology; Plasma cells; Plasma Cells - metabolism; Plasma Cells - pathology; proteins; Proto-Oncogene Proteins - metabolism; quantitative polymerase chain reaction; Receptors, Interleukin-6 - metabolism; Repressor Proteins - metabolism; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic acid; RNA; Rodents; Signatures; STAT3 Transcription Factor - metabolism; Studies; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins - metabolism; Transfection; Tumor cell line; Tumor Suppressor Protein p53 - metabolism; Tumors; Up-Regulation

Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery of microRNAs (miRNAs), a class of small noncoding RNAs targeting multiple mRNAs, has revealed a new level of gene expression regulation. To determine whether miRNAs play a role in t...