Multimodal two-photon imaging using a second harmonic generation-specific dye

• Published in: Nature communications Vol. 7; no. 7; pp. 11557 - 10
• Main Authors: 百武 篤也, 新井 達郎, Nuriya Mutsuo, Fukushima Shun, Momotake Atsuya, Shinotsuka Takanori, Yasui Masato, Arai Tatsuo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 09.05.2016; Nature Publishing Group UK; Nature Portfolio
• Subjects: 14/34; 14/69; 631/1647/1888/1493; 631/80/2373; 64/60; 9/10; 9/74; Biological samples; Dyes; Humanities and Social Sciences; Microscopy; multidisciplinary; NMR; Nuclear magnetic resonance; Plasma; Science; Science (multidisciplinary); Japan

Second harmonic generation (SHG) imaging can be used to visualize unique biological phenomena, but currently available dyes limit its application owing to the strong fluorescent signals that they generate together with SHG. Here we report the first non-fluorescent and membrane potential-sensitive SH...