Lactoferrin a multiple bioactive protein: An overview

• Published in: Biochimica et biophysica acta Vol. 1820; no. 3; pp. 226 - 236
• Main Authors: García-Montoya, Isui Abril, Cendón, Tania Siqueiros, Arévalo-Gallegos, Sigifredo, Rascón-Cruz, Quintín
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2012
• Subjects: Adaptive Immunity; Animals; Anti-Bacterial Agents; anti-infective properties; Anti-Inflammatory Agents; Antifungal Agents; Antiviral Agents; application; Base Sequence; functional foods; Functional protein; glycoproteins; hosts; humans; immunomodulators; infectious diseases; iron; Iron - metabolism; Iron-binding protein; Lactoferrin; Lactoferrin - chemistry; Lactoferrin - metabolism; mechanism of action; microorganisms; milk; Milk - chemistry; pathogens; Protein Structure, Tertiary; Review; Transferrin; transferrins; Lactoferrin; Transferrin; Functional protein; Iron-binding protein

Lactoferrin (Lf) is an 80kDa iron-binding glycoprotein of the transferrin family. It is abundant in milk and in most biological fluids and is a cell-secreted molecule that bridges innate and adaptive immune function in mammals. Its protective effects range from anticancer, anti-inflammatory and immu...