Liver-expressed antimicrobial peptide 2 is a hepatokine regulated by ghrelin, nutrients, and body weight

• Published in: Scientific reports Vol. 14; no. 1; pp. 24782 - 14
• Main Authors: Islam, Md Nurul, Nabekura, Hiroki, Ueno, Hiroaki, Nishida, Takahiro, Nanashima, Atsushi, Sakoda, Hideyuki, Zhang, Weidong, Nakazato, Masamitsu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.10.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/163/2743; 692/4020/198; Animals; Antimicrobial Cationic Peptides - metabolism; Antimicrobial peptides; Aorta; Blood Glucose - metabolism; Blood levels; Blood Proteins; Body Weight; Body weight loss; Coronary vessels; Diabetes; Diabetes mellitus; Diet, High-Fat - adverse effects; Female; Gastrectomy; Ghrelin; Ghrelin - blood; Ghrelin - metabolism; Hepatic vein; Hepatokine; High fat diet; Humanities and Social Sciences; Humans; Hunger; LEAP2; Liver; Liver - metabolism; Male; Mice; Mice, Inbred C57BL; mRNA; multidisciplinary; Nutrients - metabolism; Obesity; Obesity - metabolism; Oils & fats; Palmitic acid; Peptides; Portal vein; Science; Science (multidisciplinary); Secretion; Veins & arteries; Vertical sleeve gastrectomy; Weight control; Obesity; Vertical sleeve gastrectomy; Diabetes; LEAP2; Ghrelin; Hepatokine

Liver-expressed antimicrobial peptide 2 (LEAP2) is a peptide that counteracts the hunger hormone ghrelin-induced functions. Recently, we showed that vertical sleeve gastrectomy (VSG) did not alter the serum LEAP2 concentration in individuals with obesity. Here, we investigated the effects of VSG in...