Mosquito odour-baited mass trapping reduced malaria transmission intensity: a result from a controlled before-and-after intervention study

• Published in: BMC medicine Vol. 22; no. 1; p. 41
• Main Authors: Debebe, Yared, Tekie, Habte, Dugassa, Sisay, Hopkins, Richard J, Hill, Sharon Rose, Ignell, Rickard
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.01.2024; BioMed Central; BMC
• Subjects: Analysis; Animals; Anopheles; Anopheles - physiology; Anopheles arabiensis; Aquatic insects; Carbon dioxide; Care and treatment; Cattle; Chemical ecology; Cross-Sectional Studies; Diagnosis; Disease transmission; Epidemiology; Females; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; Humans; Inoculation; Insecticides; Intervention; Malaria; Malaria - epidemiology; Malaria - prevention & control; Malaria prevalence; Malaria vectors; Mosquito Control - methods; Mosquito Vectors; Mosquitoes; New technology; Odor; Odorants; Outdoors; Physiology; Polyethylene; Prevention; Public Health, Global Health, Social Medicine and Epidemiology; Reduction; Risk factors; Rural areas; Rural communities; Surveys; Towns; Trapping; Traps; Urine; Vector-borne diseases; Vectors; Villages; Sweden; China; Sub-Saharan Africa; Ethiopia; Anopheles; Malaria prevalence; Malaria vectors; Chemical ecology
• DOI: 10.1186/s12916-024-03255-9
• ISSN: 1741-7015

Conventional vector control strategies have significantly reduced the malaria burden. The sustainability of these methods is currently challenged. Odour-based traps are emerging technologies that can complement the existing tools. Implementation of odour-based traps for mass trapping is limited due to the restricted range of vectors caught with available carbon dioxide-dependent lures, and the lack of comprehensive field studies. The objective of this study was to assess the impact of odour-mediated mass trapping targeting outdoor vectors, using a synthetic cattle urine lure that attracts a wide range of vector species in a variety of physiological states, on malaria prevalence and entomological parameters to determine malaria transmission intensities. A controlled before-and-after study was conducted in two rural communities in southern Ethiopia. Baseline monthly entomological and seasonal cross-sectional malaria prevalence surveys were conducted in both communities for a year. Then, mass trapping of mosquitoes was conducted in one of the villages, while the monthly entomological surveillance and seasonal malaria prevalence surveys continued in both villages. Generalised linear mixed models were constructed and tested to determine which factors were significantly affected by the intervention. Mass trapping contributed to the reduction of the population of the principal malaria vector, Anopheles arabiensis, and the associated entomological indicators, the human bite rate (HBR) and the entomological inoculation rate (EIR), in the intervention village compared to the control village. The intervention village had an average HBR by An. arabiensis of 3.0 (95% CI 1.4-4.6) during the peak malaria transmission season, compared to 10.5 (95% CI - 0.5-21.5; P < 0.0001) in the control village. The intervention village (mean 0.02, 95% CI - 0.05-0.4.8) had a daily EIR eight times lower than the control village (mean 0.17, 95% CI), which likely contributed to the reduced malaria prevalence in the intervention community following its introduction by ca. 60% (95% CI 55-63). The combined use of odour-based mass trapping and conventional control strategies coincided with a reduction of human-vector contact and malaria prevalence, providing support for odour-baited technologies as a viable option for next-generation vector control tools. Further cluster-randomised control studies are recommended in different eco-epidemiological settings with varying malaria transmission intensities.