Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging

• Published in: Aging and disease Vol. 9; no. 5; pp. 880 - 900
• Main Authors: Fournet, Maxime, Bonté, Frédéric, Desmoulière, Alexis
• Format: Journal Article
• Language: English
• Published: United States JKL International 01.10.2018; Kunlin Jin; JKL International LLC
• Subjects: Advanced glycation end products; Aging (Biology); Development and progression; Glycosylation; Health aspects; Life Sciences; Neurodegenerative diseases; Review; Risk factors; advanced glycation end product; aging; neurodegenerative disorders; endogenous glycation; diabetes; exogenous glycation; Endogenous glycation; Aging; Exogenous glycation; Diabetes; Neurodegenerative disorders; Advanced glycation end product

Glycation is both a physiological and pathological process which mainly affects proteins, nucleic acids and lipids. Exogenous and endogenous glycation produces deleterious reactions that take place principally in the extracellular matrix environment or within the cell cytosol and organelles. Advance...