Swept-Source Optical Coherence Tomographic Findings of Choroidal Osteoma
Purpose: To report the morphologic features of a choroidal osteoma using swept-source optical coherence tomography (SS-OCT) and fundus autofluorescence (FAF). Methods: Two eyes of two cases with a choroidal osteoma were studied using SS-OCT and FAF. Results: The location of the tumor was circumpapil...
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Published in | Case Reports in Ophthalmology Vol. 5; no. 2; pp. 195 - 202 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Basel, Switzerland
S. Karger AG
05.07.2014
Karger Publishers |
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Abstract | Purpose: To report the morphologic features of a choroidal osteoma using swept-source optical coherence tomography (SS-OCT) and fundus autofluorescence (FAF). Methods: Two eyes of two cases with a choroidal osteoma were studied using SS-OCT and FAF. Results: The location of the tumor was circumpapillary without macular involvement in case 1 and juxtapapillary with macular involvement in case 2. Both cases had a mixture of calcified and decalcified areas, and a concomitant choroidal neovascularization was found in case 2. The FAF images showed decreased autofluorescence in the central decalcified regions and relatively preserved fluorescence in marginal calcified regions in both cases. SS-OCT revealed a normal inner retina and an abnormal outer retina in both cases, and subretinal fluid in case 2. The calcified regions appeared sponge-like and were multilayered in case 2. A lamellar reflective pattern was observed in the decalcified regions in case 1, and hyperreflective mound-like areas were observed in both cases. SS-OCT demonstrated hyperreflective areas above Bruch's membrane accompanied by disruption of Bruch's membrane in case 1. The chorioscleral border was visible in both cases. Conclusions: The FAF pattern in the calcified and decalcified areas of the choroidal osteoma may correspond to the different stage of tumor evolution. The SS-OCT findings indicate that choroidal osteomas can have characteristic reflective patterns and alterations of the overlying retina. |
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AbstractList | To report the morphologic features of a choroidal osteoma using swept-source optical coherence tomography (SS-OCT) and fundus autofluorescence (FAF).
Two eyes of two cases with a choroidal osteoma were studied using SS-OCT and FAF.
The location of the tumor was circumpapillary without macular involvement in case 1 and juxtapapillary with macular involvement in case 2. Both cases had a mixture of calcified and decalcified areas, and a concomitant choroidal neovascularization was found in case 2. The FAF images showed decreased autofluorescence in the central decalcified regions and relatively preserved fluorescence in marginal calcified regions in both cases. SS-OCT revealed a normal inner retina and an abnormal outer retina in both cases, and subretinal fluid in case 2. The calcified regions appeared sponge-like and were multilayered in case 2. A lamellar reflective pattern was observed in the decalcified regions in case 1, and hyperreflective mound-like areas were observed in both cases. SS-OCT demonstrated hyperreflective areas above Bruch's membrane accompanied by disruption of Bruch's membrane in case 1. The chorioscleral border was visible in both cases.
The FAF pattern in the calcified and decalcified areas of the choroidal osteoma may correspond to the different stage of tumor evolution. The SS-OCT findings indicate that choroidal osteomas can have characteristic reflective patterns and alterations of the overlying retina. Purpose: To report the morphologic features of a choroidal osteoma using swept-source optical coherence tomography (SS-OCT) and fundus autofluorescence (FAF). Methods: Two eyes of two cases with a choroidal osteoma were studied using SS-OCT and FAF. Results: The location of the tumor was circumpapillary without macular involvement in case 1 and juxtapapillary with macular involvement in case 2. Both cases had a mixture of calcified and decalcified areas, and a concomitant choroidal neovascularization was found in case 2. The FAF images showed decreased autofluorescence in the central decalcified regions and relatively preserved fluorescence in marginal calcified regions in both cases. SS-OCT revealed a normal inner retina and an abnormal outer retina in both cases, and subretinal fluid in case 2. The calcified regions appeared sponge-like and were multilayered in case 2. A lamellar reflective pattern was observed in the decalcified regions in case 1, and hyperreflective mound-like areas were observed in both cases. SS-OCT demonstrated hyperreflective areas above Bruch's membrane accompanied by disruption of Bruch's membrane in case 1. The chorioscleral border was visible in both cases. Conclusions: The FAF pattern in the calcified and decalcified areas of the choroidal osteoma may correspond to the different stage of tumor evolution. The SS-OCT findings indicate that choroidal osteomas can have characteristic reflective patterns and alterations of the overlying retina. To report the morphologic features of a choroidal osteoma using swept-source optical coherence tomography (SS-OCT) and fundus autofluorescence (FAF).PURPOSETo report the morphologic features of a choroidal osteoma using swept-source optical coherence tomography (SS-OCT) and fundus autofluorescence (FAF).Two eyes of two cases with a choroidal osteoma were studied using SS-OCT and FAF.METHODSTwo eyes of two cases with a choroidal osteoma were studied using SS-OCT and FAF.The location of the tumor was circumpapillary without macular involvement in case 1 and juxtapapillary with macular involvement in case 2. Both cases had a mixture of calcified and decalcified areas, and a concomitant choroidal neovascularization was found in case 2. The FAF images showed decreased autofluorescence in the central decalcified regions and relatively preserved fluorescence in marginal calcified regions in both cases. SS-OCT revealed a normal inner retina and an abnormal outer retina in both cases, and subretinal fluid in case 2. The calcified regions appeared sponge-like and were multilayered in case 2. A lamellar reflective pattern was observed in the decalcified regions in case 1, and hyperreflective mound-like areas were observed in both cases. SS-OCT demonstrated hyperreflective areas above Bruch's membrane accompanied by disruption of Bruch's membrane in case 1. The chorioscleral border was visible in both cases.RESULTSThe location of the tumor was circumpapillary without macular involvement in case 1 and juxtapapillary with macular involvement in case 2. Both cases had a mixture of calcified and decalcified areas, and a concomitant choroidal neovascularization was found in case 2. The FAF images showed decreased autofluorescence in the central decalcified regions and relatively preserved fluorescence in marginal calcified regions in both cases. SS-OCT revealed a normal inner retina and an abnormal outer retina in both cases, and subretinal fluid in case 2. The calcified regions appeared sponge-like and were multilayered in case 2. A lamellar reflective pattern was observed in the decalcified regions in case 1, and hyperreflective mound-like areas were observed in both cases. SS-OCT demonstrated hyperreflective areas above Bruch's membrane accompanied by disruption of Bruch's membrane in case 1. The chorioscleral border was visible in both cases.The FAF pattern in the calcified and decalcified areas of the choroidal osteoma may correspond to the different stage of tumor evolution. The SS-OCT findings indicate that choroidal osteomas can have characteristic reflective patterns and alterations of the overlying retina.CONCLUSIONSThe FAF pattern in the calcified and decalcified areas of the choroidal osteoma may correspond to the different stage of tumor evolution. The SS-OCT findings indicate that choroidal osteomas can have characteristic reflective patterns and alterations of the overlying retina. |
Author | Mitamura, Yoshinori Egawa, Mariko Nagasawa, Toshihiko Semba, Kentaro Hayashi, Yuki |
AuthorAffiliation | b Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Japan a Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Himeji, Japan |
AuthorAffiliation_xml | – name: a Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Himeji, Japan – name: b Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Japan |
Author_xml | – sequence: 1 givenname: Yuki surname: Hayashi fullname: Hayashi, Yuki email: yhayashi@tokushima-u.ac.jp – sequence: 2 givenname: Yoshinori surname: Mitamura fullname: Mitamura, Yoshinori – sequence: 3 givenname: Mariko orcidid: 0000-0001-5759-598X surname: Egawa fullname: Egawa, Mariko – sequence: 4 givenname: Kentaro surname: Semba fullname: Semba, Kentaro – sequence: 5 givenname: Toshihiko surname: Nagasawa fullname: Nagasawa, Toshihiko |
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CitedBy_id | crossref_primary_10_1016_j_ajo_2024_02_025 crossref_primary_10_1007_s00717_019_0427_z crossref_primary_10_1007_s40135_018_0158_3 crossref_primary_10_17816_OV15931 crossref_primary_10_3928_23258160_20161219_14 crossref_primary_10_3390_app12094472 crossref_primary_10_1177_2515841420922740 crossref_primary_10_4103_IJO_IJO_2375_23 |
Cites_doi | 10.1016/S0002-9394(01)01336-8 10.1186/1869-5760-4-7 10.1097/IAE.0000000000000017 10.1001/archopht.116.10.1337 10.1001/archopht.1978.03910060378017 10.1016/S0002-9394(00)00503-1 10.1001/archopht.123.12.1658 10.1590/S0004-27492013000300012 10.1097/IAE.0b013e318296575c 10.2147/OPTH.S58114 10.1167/iovs.13-12350 10.1001/archopht.1978.03910050204002 10.1016/j.ajo.2011.10.025 10.1016/j.ophtha.2007.07.037 10.1136/bjo.2011.202408 |
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Keywords | Swept-source optical coherence tomography Fundus autofluorescence Choroidal osteoma |
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References | Nagasawa T, Mitamura Y, Katome T, Nagasato D, Tabuchi H: Swept-source optical coherence tomographic findings in morning glory syndrome. Retina 2014;34:206-208.2371940110.1097/IAE.0b013e318296575c Nagasawa T, Mitamura Y, Katome T, Shinomiya K, Naito T, Nagasato D, Shimizu Y, Tabuchi H, Kiuchi Y: Macular choroidal thickness and volume in healthy pediatric individuals measured by swept-source optical coherence tomography. Invest Ophthalmol Vis Sci 2013;54:7068-7074.2410611410.1167/iovs.13-12350 Erol MK, Coban DT, Ceran BB, Bulut M: Enhanced depth imaging optical coherence tomography and fundus autofluorescence findings in bilateral choroidal osteoma: a case report. Arq Bras Oftalmol 2013;76:189-191.2392908210.1590/S0004-27492013000300012 Egawa M, Mitamura Y, Hayashi Y, Naito T: Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma. Clin Ophthalmol 2014;8:335-341.2452019010.2147/OPTH.S58114 Ide T, Ohguro N, Hayashi A, Yamamoto S, Nakagawa Y, Nagae Y, Tano Y: Optical coherence tomography patterns of choroidal osteoma. Am J Ophthalmol 2000;130:131-134.1100428010.1016/S0002-9394(00)00503-1 Gass JD, Guerry RK, Jack RL, Harris G: Choroidal osteoma. Arch Ophthalmol 1978;96:428-435.62967910.1001/archopht.1978.03910050204002 Fukasawa A, Iijima H: Optical coherence tomography of choroidal osteoma. Am J Ophthalmol 2002;133:419-421.1186098810.1016/S0002-9394(01)01336-8 Shields CL, Perez B, Materin MA, Mehta S, Shields JA: Optical coherence tomography of choroidal osteoma in 22 cases: evidence for photoreceptor atrophy over the decalcified portion of the tumor. Ophthalmology 2007;114:e53-e58.1788417110.1016/j.ophtha.2007.07.037 Alyward GW, Chang TS, Pautler SE, Gass JD: A long-term follow up of choroidal osteoma. Arch Ophthalmol 1998;116:1337-1341.979063310.1001/archopht.116.10.1337 Shields CL, Sun H, Demirci H, Shields JA: Factors predictive of tumor growth, tumor decalcification, choroidal neovascularization, and visual outcome in 74 eyes with choroidal osteoma. Arch Ophthalmol 2005;123:1658-1666.1634443610.1001/archopht.123.12.1658 Navajas EV, Costa RA, Calucci D, Hammoudi DS, Simpson ER, Altomare F: Multimodal fundus imaging in choroidal osteoma. Am J Ophthalmol 2012;153:890-895.2226515510.1016/j.ajo.2011.10.025 Freton A, Finger PT: Spectral domain-optical coherence tomography analysis of choroidal osteoma. Br J Ophthalmol 2012;95:224-228.2152741510.1136/bjo.2011.202408 Egawa M, Mitamura Y, Hayashi Y, Semba K, Naito T: Changes of fundus autofluorescence and spectral-domain optical coherence tomographic findings after treatment of primary intraocular lymphoma. J Ophthalmic Inflamm Infect 2014;4:7.2455925910.1186/1869-5760-4-7 Pellegrini M, Invernizzi A, Giani A, Staurenghi G: Enhanced depth imaging optical coherence tomography features of choroidal osteoma. Retina 2013, Epub ahead of print.2426347010.1097/IAE.0000000000000017 Williams AT, Font RL, Van Dyk HJ, Riekhof FT: Osseous choristoma of the choroid simulating a choroidal melanoma. Association with a positive 32P test. Arch Ophthalmol 1978;96:1874-1877.69762610.1001/archopht.1978.03910060378017 ref13 ref12 ref15 ref14 ref11 ref10 ref2 ref1 ref8 ref7 ref9 ref4 ref3 ref6 ref5 |
References_xml | – reference: Williams AT, Font RL, Van Dyk HJ, Riekhof FT: Osseous choristoma of the choroid simulating a choroidal melanoma. Association with a positive 32P test. Arch Ophthalmol 1978;96:1874-1877.69762610.1001/archopht.1978.03910060378017 – reference: Navajas EV, Costa RA, Calucci D, Hammoudi DS, Simpson ER, Altomare F: Multimodal fundus imaging in choroidal osteoma. Am J Ophthalmol 2012;153:890-895.2226515510.1016/j.ajo.2011.10.025 – reference: Pellegrini M, Invernizzi A, Giani A, Staurenghi G: Enhanced depth imaging optical coherence tomography features of choroidal osteoma. Retina 2013, Epub ahead of print.2426347010.1097/IAE.0000000000000017 – reference: Egawa M, Mitamura Y, Hayashi Y, Naito T: Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma. Clin Ophthalmol 2014;8:335-341.2452019010.2147/OPTH.S58114 – reference: Alyward GW, Chang TS, Pautler SE, Gass JD: A long-term follow up of choroidal osteoma. Arch Ophthalmol 1998;116:1337-1341.979063310.1001/archopht.116.10.1337 – reference: Gass JD, Guerry RK, Jack RL, Harris G: Choroidal osteoma. Arch Ophthalmol 1978;96:428-435.62967910.1001/archopht.1978.03910050204002 – reference: Nagasawa T, Mitamura Y, Katome T, Shinomiya K, Naito T, Nagasato D, Shimizu Y, Tabuchi H, Kiuchi Y: Macular choroidal thickness and volume in healthy pediatric individuals measured by swept-source optical coherence tomography. Invest Ophthalmol Vis Sci 2013;54:7068-7074.2410611410.1167/iovs.13-12350 – reference: Fukasawa A, Iijima H: Optical coherence tomography of choroidal osteoma. Am J Ophthalmol 2002;133:419-421.1186098810.1016/S0002-9394(01)01336-8 – reference: Nagasawa T, Mitamura Y, Katome T, Nagasato D, Tabuchi H: Swept-source optical coherence tomographic findings in morning glory syndrome. Retina 2014;34:206-208.2371940110.1097/IAE.0b013e318296575c – reference: Ide T, Ohguro N, Hayashi A, Yamamoto S, Nakagawa Y, Nagae Y, Tano Y: Optical coherence tomography patterns of choroidal osteoma. Am J Ophthalmol 2000;130:131-134.1100428010.1016/S0002-9394(00)00503-1 – reference: Erol MK, Coban DT, Ceran BB, Bulut M: Enhanced depth imaging optical coherence tomography and fundus autofluorescence findings in bilateral choroidal osteoma: a case report. Arq Bras Oftalmol 2013;76:189-191.2392908210.1590/S0004-27492013000300012 – reference: Shields CL, Perez B, Materin MA, Mehta S, Shields JA: Optical coherence tomography of choroidal osteoma in 22 cases: evidence for photoreceptor atrophy over the decalcified portion of the tumor. Ophthalmology 2007;114:e53-e58.1788417110.1016/j.ophtha.2007.07.037 – reference: Egawa M, Mitamura Y, Hayashi Y, Semba K, Naito T: Changes of fundus autofluorescence and spectral-domain optical coherence tomographic findings after treatment of primary intraocular lymphoma. J Ophthalmic Inflamm Infect 2014;4:7.2455925910.1186/1869-5760-4-7 – reference: Freton A, Finger PT: Spectral domain-optical coherence tomography analysis of choroidal osteoma. Br J Ophthalmol 2012;95:224-228.2152741510.1136/bjo.2011.202408 – reference: Shields CL, Sun H, Demirci H, Shields JA: Factors predictive of tumor growth, tumor decalcification, choroidal neovascularization, and visual outcome in 74 eyes with choroidal osteoma. Arch Ophthalmol 2005;123:1658-1666.1634443610.1001/archopht.123.12.1658 – ident: ref5 doi: 10.1016/S0002-9394(01)01336-8 – ident: ref13 doi: 10.1186/1869-5760-4-7 – ident: ref8 doi: 10.1097/IAE.0000000000000017 – ident: ref3 doi: 10.1001/archopht.116.10.1337 – ident: ref14 doi: 10.1001/archopht.1978.03910060378017 – ident: ref4 doi: 10.1016/S0002-9394(00)00503-1 – ident: ref15 doi: 10.1001/archopht.123.12.1658 – ident: ref9 doi: 10.1590/S0004-27492013000300012 – ident: ref10 doi: 10.1097/IAE.0b013e318296575c – ident: ref12 doi: 10.2147/OPTH.S58114 – ident: ref11 doi: 10.1167/iovs.13-12350 – ident: ref1 doi: 10.1001/archopht.1978.03910050204002 – ident: ref2 doi: 10.1016/j.ajo.2011.10.025 – ident: ref6 doi: 10.1016/j.ophtha.2007.07.037 – ident: ref7 doi: 10.1136/bjo.2011.202408 |
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Snippet | Purpose: To report the morphologic features of a choroidal osteoma using swept-source optical coherence tomography (SS-OCT) and fundus autofluorescence (FAF).... To report the morphologic features of a choroidal osteoma using swept-source optical coherence tomography (SS-OCT) and fundus autofluorescence (FAF). Two eyes... To report the morphologic features of a choroidal osteoma using swept-source optical coherence tomography (SS-OCT) and fundus autofluorescence (FAF).PURPOSETo... |
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SubjectTerms | Choroidal osteoma Fundus autofluorescence Ophthalmology Published online: July, 2014 Published: July 2014 RE1-994 Swept-source optical coherence tomography |
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Title | Swept-Source Optical Coherence Tomographic Findings of Choroidal Osteoma |
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