Increased progranulin in the skin of amyotrophic lateral sclerosis: An immunohistochemical study

• Published in: Journal of the neurological sciences Vol. 309; no. 1; pp. 110 - 114
• Main Authors: Yasui, Kanako, Oketa, Yoshihiko, Higashida, Kazuhiro, Fukazawa, Hiroyuki, Ono, Seiitsu
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.10.2011; Elsevier
• Subjects: Adult; Aged; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - diagnosis; Amyotrophic Lateral Sclerosis - metabolism; Biological and medical sciences; Biomarkers - metabolism; Epidermis; Female; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins - biosynthesis; Male; Medical sciences; Middle Aged; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; Progranulin; Protein Precursors - biosynthesis; Skin; Skin - chemistry; Skin - metabolism; Up-Regulation - physiology; Immunohistochemistry; Amyotrophic lateral sclerosis; Epidermis; Skin; Progranulin; Nervous system diseases; Central nervous system disease; Degenerative disease; Spinal cord disease

It has been demonstrated that progranulin (PGRN) is a neurotrophic factor that enhances neuronal survival and axonal growth. Several lines of evidence have indicated that PGRN plays a role in the pathomechanism of amyotrophic lateral sclerosis (ALS). However, there has no study of PGRN in ALS skin....