Management of Type 2 Diabetes: Current Strategies, Unfocussed Aspects, Challenges, and Alternatives

• Published in: Medical principles and practice Vol. 30; no. 2; pp. 109 - 121
• Main Authors: Borse, Swapnil P., Chhipa, Abu Sufiyan, Sharma, Vipin, Singh, Devendra Pratap, Nivsarkar, Manish
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.04.2021
• Subjects: Adipose Tissue - metabolism; Apolipoproteins; Blood Glucose; Diabetes; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - therapy; Diet; Dietary Supplements; Drug Therapy, Combination; Exercise; Failure; Gastrointestinal Microbiome - physiology; Genes; Gestational diabetes; Glucagon; Glucose; Healthy Lifestyle; Homeostasis; Hormones; Humans; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents - therapeutic use; Hypotheses; Insulin resistance; Islet Amyloid Polypeptide - metabolism; Islets of Langerhans - metabolism; Kinases; Pancreas; Pathogenesis; Pathophysiology; Patients; Physiology; Phytotherapy - methods; Proteins; Resistin - metabolism; Review; Roles; Sleep; Type-2 diabetes mellitus; Lifestyle modifications; β-cells; Phytoconstituents; Insulin resistance; Genetics; Diabetes

Type 2 diabetes mellitus (T2DM) accounts for >90% of the cases of diabetes in adults. Resistance to insulin action is the major cause that leads to chronic hyperglycemia in diabetic patients. T2DM is the consequence of activation of multiple pathways and factors involved in insulin resistance and...