Recent Trends on Mitigative Effect of Probiotics on Oxidative-Stress-Induced Gut Dysfunction in Broilers under Necrotic Enteritis Challenge: A Review

Gut health includes normal intestinal physiology, complete intestinal epithelial barrier, efficient immune response, sustained inflammatory balance, healthy microbiota, high nutrient absorption efficiency, nutrient metabolism, and energy balance. One of the diseases that causes severe economic losse...

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Published inAntioxidants Vol. 12; no. 4; p. 911
Main Authors Obianwuna, Uchechukwu Edna, Agbai Kalu, Nenna, Wang, Jing, Zhang, Haijun, Qi, Guanghai, Qiu, Kai, Wu, Shugeng
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.04.2023
MDPI
Subjects
adhesion
antibiotics
Antioxidants
Apoptosis
Bacteriocins
biosecurity
broilers
Broilers (Poultry)
competitive exclusion
Cytokines
death
Digestive system
Disease
Endotoxins
Energy balance
Energy metabolism
Enteritis
Enzymes
Food security
Gastrointestinal tract
growth performance
gut health
Health aspects
Homeostasis
Immune response
Immunoglobulins
Inflammation
Intestinal microflora
intestinal microorganisms
intestinal mucosa
Intestine
metabolites
Microbiomes
Microbiota
Morphology
Mortality
necrotic enteritis
nutrient uptake
Nutrient utilization
Nutrients
Oxidative stress
Pathogens
Permeability
Physiology
Poultry
poultry production
Probiotics
Protein structure
Protein transport
Proteins
Review
secretion
Small intestine
therapeutics
tight junctions
Trends
United States
gut health
broilers
necrotic enteritis
oxidative stress
probiotics
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Abstract Gut health includes normal intestinal physiology, complete intestinal epithelial barrier, efficient immune response, sustained inflammatory balance, healthy microbiota, high nutrient absorption efficiency, nutrient metabolism, and energy balance. One of the diseases that causes severe economic losses to farmers is necrotic enteritis, which occurs primarily in the gut and is associated with high mortality rate. Necrotic enteritis (NE) primarily damages the intestinal mucosa, thereby inducing intestinal inflammation and high immune response which diverts nutrients and energy needed for growth to response mediated effects. In the era of antibiotic ban, dietary interventions like microbial therapy (probiotics) to reduce inflammation, paracellular permeability, and promote gut homeostasis may be the best way to reduce broiler production losses. The current review highlights the severity effects of NE; intestinal inflammation, gut lesions, alteration of gut microbiota balance, cell apoptosis, reduced growth performance, and death. These negative effects are consequences of; disrupted intestinal barrier function and villi development, altered expression of tight junction proteins and protein structure, increased translocation of endotoxins and excessive stimulation of proinflammatory cytokines. We further explored the mechanisms by which probiotics mitigate NE challenge and restore the gut integrity of birds under disease stress; synthesis of metabolites and bacteriocins, competitive exclusion of pathogens, upregulation of tight junction proteins and adhesion molecules, increased secretion of intestinal secretory immunoglobulins and enzymes, reduction in pro-inflammatory cytokines and immune response and the increased production of anti-inflammatory cytokines and immune boost via the modulation of the TLR/NF-ĸ pathway. Furthermore, increased beneficial microbes in the gut microbiome improve nutrient utilization, host immunity, and energy metabolism. Probiotics along with biosecurity measures could mitigate the adverse effects of NE in broiler production.
AbstractList Gut health includes normal intestinal physiology, complete intestinal epithelial barrier, efficient immune response, sustained inflammatory balance, healthy microbiota, high nutrient absorption efficiency, nutrient metabolism, and energy balance. One of the diseases that causes severe economic losses to farmers is necrotic enteritis, which occurs primarily in the gut and is associated with high mortality rate. Necrotic enteritis (NE) primarily damages the intestinal mucosa, thereby inducing intestinal inflammation and high immune response which diverts nutrients and energy needed for growth to response mediated effects. In the era of antibiotic ban, dietary interventions like microbial therapy (probiotics) to reduce inflammation, paracellular permeability, and promote gut homeostasis may be the best way to reduce broiler production losses. The current review highlights the severity effects of NE; intestinal inflammation, gut lesions, alteration of gut microbiota balance, cell apoptosis, reduced growth performance, and death. These negative effects are consequences of; disrupted intestinal barrier function and villi development, altered expression of tight junction proteins and protein structure, increased translocation of endotoxins and excessive stimulation of proinflammatory cytokines. We further explored the mechanisms by which probiotics mitigate NE challenge and restore the gut integrity of birds under disease stress; synthesis of metabolites and bacteriocins, competitive exclusion of pathogens, upregulation of tight junction proteins and adhesion molecules, increased secretion of intestinal secretory immunoglobulins and enzymes, reduction in pro-inflammatory cytokines and immune response and the increased production of anti-inflammatory cytokines and immune boost via the modulation of the TLR/NF-ĸ pathway. Furthermore, increased beneficial microbes in the gut microbiome improve nutrient utilization, host immunity, and energy metabolism. Probiotics along with biosecurity measures could mitigate the adverse effects of NE in broiler production.Gut health includes normal intestinal physiology, complete intestinal epithelial barrier, efficient immune response, sustained inflammatory balance, healthy microbiota, high nutrient absorption efficiency, nutrient metabolism, and energy balance. One of the diseases that causes severe economic losses to farmers is necrotic enteritis, which occurs primarily in the gut and is associated with high mortality rate. Necrotic enteritis (NE) primarily damages the intestinal mucosa, thereby inducing intestinal inflammation and high immune response which diverts nutrients and energy needed for growth to response mediated effects. In the era of antibiotic ban, dietary interventions like microbial therapy (probiotics) to reduce inflammation, paracellular permeability, and promote gut homeostasis may be the best way to reduce broiler production losses. The current review highlights the severity effects of NE; intestinal inflammation, gut lesions, alteration of gut microbiota balance, cell apoptosis, reduced growth performance, and death. These negative effects are consequences of; disrupted intestinal barrier function and villi development, altered expression of tight junction proteins and protein structure, increased translocation of endotoxins and excessive stimulation of proinflammatory cytokines. We further explored the mechanisms by which probiotics mitigate NE challenge and restore the gut integrity of birds under disease stress; synthesis of metabolites and bacteriocins, competitive exclusion of pathogens, upregulation of tight junction proteins and adhesion molecules, increased secretion of intestinal secretory immunoglobulins and enzymes, reduction in pro-inflammatory cytokines and immune response and the increased production of anti-inflammatory cytokines and immune boost via the modulation of the TLR/NF-ĸ pathway. Furthermore, increased beneficial microbes in the gut microbiome improve nutrient utilization, host immunity, and energy metabolism. Probiotics along with biosecurity measures could mitigate the adverse effects of NE in broiler production.
Gut health includes normal intestinal physiology, complete intestinal epithelial barrier, efficient immune response, sustained inflammatory balance, healthy microbiota, high nutrient absorption efficiency, nutrient metabolism, and energy balance. One of the diseases that causes severe economic losses to farmers is necrotic enteritis, which occurs primarily in the gut and is associated with high mortality rate. Necrotic enteritis (NE) primarily damages the intestinal mucosa, thereby inducing intestinal inflammation and high immune response which diverts nutrients and energy needed for growth to response mediated effects. In the era of antibiotic ban, dietary interventions like microbial therapy (probiotics) to reduce inflammation, paracellular permeability, and promote gut homeostasis may be the best way to reduce broiler production losses. The current review highlights the severity effects of NE; intestinal inflammation, gut lesions, alteration of gut microbiota balance, cell apoptosis, reduced growth performance, and death. These negative effects are consequences of; disrupted intestinal barrier function and villi development, altered expression of tight junction proteins and protein structure, increased translocation of endotoxins and excessive stimulation of proinflammatory cytokines. We further explored the mechanisms by which probiotics mitigate NE challenge and restore the gut integrity of birds under disease stress; synthesis of metabolites and bacteriocins, competitive exclusion of pathogens, upregulation of tight junction proteins and adhesion molecules, increased secretion of intestinal secretory immunoglobulins and enzymes, reduction in pro-inflammatory cytokines and immune response and the increased production of anti-inflammatory cytokines and immune boost via the modulation of the TLR/NF-ĸ pathway. Furthermore, increased beneficial microbes in the gut microbiome improve nutrient utilization, host immunity, and energy metabolism. Probiotics along with biosecurity measures could mitigate the adverse effects of NE in broiler production.
Audience Academic
Author Qi, Guanghai
Qiu, Kai
Wu, Shugeng
Zhang, Haijun
Agbai Kalu, Nenna
Obianwuna, Uchechukwu Edna
Wang, Jing
AuthorAffiliation 1 National Engineering Research Center of Biological Feed, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China
2 Department of Animal Science, Ahmadu Bello University, Zaria 810211, Nigeria
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Cites_doi 10.1016/j.bpj.2021.01.003
10.1007/s12602-018-9434-7
10.3390/antiox8070235
10.1007/s12602-020-09709-9
10.1038/nature11552
10.1155/2018/7276523
10.1016/j.psj.2021.101358
10.3390/microorganisms7050123
10.1016/j.psj.2022.101751
10.1111/jfpp.12679
10.1016/j.envint.2017.07.003
10.3390/ani9110985
10.1016/j.dci.2005.12.002
10.1007/s12602-020-09643-w
10.1016/j.cytogfr.2011.10.001
10.36380/jwpr.2020.61
10.1186/s12937-016-0186-5
10.3945/ajcn.110.010132
10.1093/jas/skz383
10.1016/j.psj.2022.101997
10.1128/IAI.70.6.3130-3142.2002
10.1007/s12602-021-09901-5
10.3389/fmicb.2016.01416
10.1097/MIB.0000000000000011
10.1002/vms3.412
10.1016/j.livsci.2019.03.009
10.1111/asj.13205
10.3390/ani12223085
10.1016/j.psj.2022.102237
10.3389/fimmu.2017.01592
10.1007/s11745-012-3680-3
10.1016/j.anifeedsci.2018.07.012
10.1111/j.1749-6632.2012.06553.x
10.1080/03079457.2016.1158780
10.1186/s13568-020-01153-w
10.1017/S0007114513003863
10.3389/fmicb.2018.01716
10.3382/ps/pey116
10.1080/1828051X.2021.2012092
10.3390/pathogens3010187
10.1371/journal.pone.0002945
10.1017/S0043933913000627
10.1016/j.ibmb.2019.04.005
10.3390/microorganisms7030071
10.3382/ps/pez282
10.3390/microorganisms10010152
10.4049/jimmunol.165.7.3951
10.3389/fvets.2019.00114
10.1098/rsob.170104
10.1146/annurev.nu.15.070195.000343
10.1038/bjp.2008.9
10.1186/s12876-014-0189-7
10.1080/1828051X.2022.2059022
10.3389/fmicb.2021.623739
10.3389/fmicb.2017.02081
10.3382/ps/pey119
10.3382/ps/pey035
10.1371/journal.pone.0232781
10.1126/science.1261833
10.1007/s12602-021-09867-4
10.3184/175815515X14291701859483
10.1016/j.bj.2022.03.004
10.3390/cells8091075
10.1038/s41598-018-33762-8
10.1089/ars.2006.8.1865
10.3390/microorganisms8050757
10.1016/j.psj.2021.101168
10.1080/03079457.2016.1150587
10.1038/ncomms3610
10.1155/2016/4893501
10.5713/ajas.19.0427
10.1017/S0007114516004116
10.1186/s13568-017-0439-5
10.1186/s12934-019-1161-6
10.1155/2021/2549541
10.1371/journal.ppat.1005902
10.1111/jpn.13082
10.7717/peerj.12538
10.1016/j.psj.2021.101412
10.1016/j.psj.2021.01.004
10.1016/j.anifeedsci.2016.05.004
10.3748/wjg.v21.i29.8787
10.1016/j.psj.2020.10.019
10.3389/fmicb.2018.00049
10.3382/ps/pez460
10.1038/nrmicro3420
10.1001/archotol.124.7.777
10.1007/s12602-019-09597-8
10.3382/ps/pez223
10.1159/000443360
10.3390/biology11050633
10.1080/10408398.2016.1152230
10.1080/10408398.2011.619671
10.1038/s41426-018-0144-8
10.3390/ani11123607
10.1186/s40104-022-00683-6
10.1186/s40104-018-0243-3
10.1016/j.ajpath.2012.10.014
10.1080/03079457.2011.590967
10.1590/rbz4820170298
10.1073/pnas.022493799
10.1016/j.psj.2019.12.002
10.1080/00071668.2017.1370697
10.3389/fmicb.2021.723187
10.3382/ps/pez496
10.3389/fmicb.2018.01953
10.3389/fnut.2021.786878
10.1016/j.psj.2019.10.081
10.1007/s12602-022-09924-6
10.1242/jcs.051011
10.3390/antibiotics10111427
10.1016/j.psj.2021.101055
10.1016/j.micpath.2019.103870
10.2141/jpsa.0200010
10.5713/ajas.14.0924
10.1371/journal.pone.0188634
10.1128/JB.187.5.1543-1551.2005
10.3382/ps/pey478
10.3389/fvets.2021.679368
10.3389/fvets.2021.680742
10.3390/microorganisms7080231
10.3390/ani12091086
10.3390/microorganisms7080257
10.1007/s00253-016-8032-4
10.3382/ps/pez368
10.3389/fvets.2019.00060
10.3382/ps/pey390
10.1111/jpn.12937
10.1128/AEM.67.9.4111-4118.2001
10.1038/s41598-019-46578-x
10.1186/s40104-017-0220-2
10.3389/fvets.2019.00108
10.3389/fimmu.2022.855426
10.1080/1828051X.2022.2148577
10.1007/s11882-012-0313-0
10.3389/fmicb.2021.798350
10.1016/j.psj.2022.101912
10.3390/genes8120350
10.1007/s12602-018-9459-y
10.3382/ps/pex417
10.21203/rs.3.rs-2292982/v1
10.1071/AN20701
10.3390/toxins9020060
10.1093/jn/130.2.396S
10.3382/ps/pey500
10.1016/j.psj.2021.101323
10.3389/fvets.2016.00071
10.1016/j.ejphar.2010.04.005
10.1038/srep16387
10.1016/j.aninu.2020.11.004
10.1016/j.tvjl.2015.04.016
10.3382/ps/pex314
10.3389/fmicb.2019.01681
10.3389/fvets.2020.572142
10.3382/ps.2012-02528
10.1038/s41598-018-38125-x
10.1186/1297-9716-43-74
10.1038/s41598-018-20059-z
10.3389/fmicb.2020.00299
10.2215/CJN.09430915
10.1080/03079457.2016.1154503
10.1111/asj.13006
10.1016/j.aninu.2020.05.004
10.1111/1574-6968.12608
10.1016/j.freeradbiomed.2019.04.005
10.1016/0168-6445(93)90057-G
10.3390/ani10030507
10.1371/journal.pone.0182426
10.1093/japr/15.2.229
10.1186/s13568-019-0914-2
10.1016/S1359-6101(03)00043-1
10.1007/s12602-021-09853-w
10.3382/ps/pew144
10.1111/jam.13347
10.3389/fmicb.2019.02309
10.1038/mi.2007.6
10.1038/s41598-017-07958-3
10.14814/phy2.12355
10.1007/s13213-015-1187-x
10.1038/emm.2017.282
10.1371/journal.pbio.0040349
10.1111/j.1439-0396.2009.00933.x
10.1016/j.psj.2021.101585
10.1016/j.psj.2021.01.005
10.1016/j.psj.2020.05.034
10.3389/fmicb.2022.914212
10.1080/00071668.2019.1662886
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Issue 4
Keywords gut health
broilers
necrotic enteritis
oxidative stress
probiotics
Language English
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References ref_94
Liang (ref_9) 2015; 28
ref_136
Pejin (ref_181) 2016; 40
ref_91
ref_90
Hu (ref_1) 2017; 107
Fasina (ref_85) 2019; 98
Morhardt (ref_167) 2019; 9
Guo (ref_33) 2021; 8
Kiu (ref_96) 2018; 7
Yenizey (ref_173) 2020; 30
ref_10
Wang (ref_67) 2021; 8
Jones (ref_5) 2006; 8
Jumpertz (ref_186) 2011; 94
Teo (ref_154) 2006; 15
Reyer (ref_3) 2015; 5
Wang (ref_14) 2017; 101
Celi (ref_74) 2019; 250
Tan (ref_106) 2014; 111
Bodinga (ref_52) 2020; 10
Davenport (ref_190) 2014; 20
Shanmugasundaram (ref_137) 2020; 99
Wang (ref_142) 2016; 116
Rho (ref_149) 2005; 187
ref_126
Park (ref_128) 2018; 2018
Shini (ref_93) 2021; 62
Khan (ref_155) 2013; 69
Jazi (ref_50) 2018; 97
Timbermont (ref_107) 2011; 40
Laplante (ref_172) 2009; 122
ref_25
Wang (ref_95) 2021; 12
Yang (ref_169) 2010; 638
ref_22
Ebeid (ref_37) 2021; 20
Apajalahti (ref_178) 2016; 221
Macpherson (ref_144) 2008; 1
Lyons (ref_189) 2017; 122
Guo (ref_16) 2013; 182
Enko (ref_134) 2016; 2016
Shamshirgaran (ref_185) 2022; 106
Jandhyala (ref_176) 2015; 21
Ballard (ref_7) 1995; 15
Cao (ref_30) 2019; 223
Zhao (ref_109) 2020; 12
Zhang (ref_188) 2018; 9
Alam (ref_140) 2002; 70
Voloshanenko (ref_130) 2013; 4
ref_158
Li (ref_170) 2019; 18
ref_151
Guo (ref_184) 2017; 8
Wang (ref_70) 2017; 8
Xu (ref_145) 2018; 8
ref_153
Deraz (ref_46) 2019; 9
ref_77
Dolezal (ref_166) 2019; 109
Huang (ref_26) 2019; 10
Smyth (ref_99) 2016; 45
ref_73
Dong (ref_55) 2020; 12
Bhattacharya (ref_133) 2017; 7
Shini (ref_31) 2020; 99
Tristram (ref_139) 1998; 124
Dorigam (ref_11) 2021; 7
Xu (ref_45) 2021; 100
Meyer (ref_68) 2020; 98
Takahashi (ref_115) 2018; 89
Huang (ref_131) 2019; 11
Shimao (ref_171) 2019; 60
Cheng (ref_119) 2018; 102
Stumpff (ref_89) 2012; 1258
Bai (ref_47) 2018; 97
LaRock (ref_108) 2015; 13
Eeckhaut (ref_121) 2016; 7
Sandvang (ref_18) 2021; 100
Zhao (ref_27) 2020; 11
Watford (ref_84) 2003; 14
ref_86
Broom (ref_78) 2018; 97
Nagahama (ref_168) 2008; 153
Cheng (ref_120) 2021; 58
Ramlucken (ref_17) 2020; 99
Salami (ref_4) 2015; 8
De (ref_163) 2000; 165
Chang (ref_132) 2020; 33
Rolfe (ref_174) 2000; 130
Gao (ref_36) 2022; 101
Zhen (ref_138) 2018; 97
Awad (ref_156) 2010; 94
Zhang (ref_15) 2021; 100
Ekim (ref_29) 2020; 99
ref_54
Zuo (ref_177) 2016; 66
ref_51
Gyawali (ref_40) 2022; 101
Park (ref_127) 2020; 99
Sallam (ref_152) 2021; 7
Hoffman (ref_81) 2016; 11
Abudabos (ref_104) 2020; 139
Ding (ref_35) 2021; 7
Li (ref_125) 2018; 9
ref_182
ref_59
Sun (ref_82) 2017; 7
Whelan (ref_113) 2019; 98
Shojadoost (ref_13) 2022; 14
ref_61
Bae (ref_118) 2021; 100
Sun (ref_65) 2022; 101
Kai (ref_71) 2021; 120
Liu (ref_57) 2022; 21
Zhao (ref_159) 2021; 13
Bischoff (ref_75) 2014; 14
ref_69
Rizzello (ref_79) 2013; 13
Qing (ref_123) 2017; 7
Ferreira (ref_164) 2012; 47
Sakomura (ref_124) 2019; 98
ref_165
Musa (ref_20) 2019; 103
Emami (ref_23) 2020; 7
ref_63
Ragheb (ref_48) 2019; 98
ref_62
Keerqin (ref_122) 2021; 100
Sokale (ref_117) 2019; 98
Rajput (ref_92) 2020; 10
Zhao (ref_12) 2022; 13
Chelakkot (ref_135) 2018; 50
Landoni (ref_34) 2015; 205
Proctor (ref_147) 2019; 6
Kurutas (ref_6) 2015; 15
Sun (ref_64) 2022; 101
Yang (ref_111) 2022; 101
Mohamed (ref_60) 2022; 12
Mishra (ref_2) 2019; 6
ref_116
Oakley (ref_87) 2014; 360
Tremaroli (ref_150) 2012; 489
Jayaraman (ref_160) 2013; 92
Shojadoost (ref_97) 2012; 43
Wu (ref_112) 2019; 9
Lange (ref_146) 2016; 34
Klaenhammer (ref_175) 1993; 12
ref_32
Thung (ref_101) 2016; 95
Kogut (ref_88) 2016; 3
ref_110
Ye (ref_72) 2021; 9
Li (ref_141) 2017; 58
ref_39
Liu (ref_56) 2022; 13
Min (ref_8) 2018; 97
ref_38
Emami (ref_53) 2021; 100
Peng (ref_157) 2019; 136
Wang (ref_114) 2018; 9
Lin (ref_58) 2023; 102
Chang (ref_148) 2019; 90
Abeddargahi (ref_66) 2022; 21
Friedman (ref_80) 2006; 30
Saitoh (ref_100) 2015; 347
Yang (ref_76) 2017; 57
Shimizu (ref_179) 2002; 99
Kan (ref_19) 2021; 12
Luan (ref_42) 2019; 98
Dabard (ref_180) 2001; 67
Lima (ref_183) 2007; 71
Liu (ref_28) 2021; 2021
ref_44
Pontin (ref_21) 2019; 6
ref_43
ref_187
Wang (ref_24) 2018; 9
ref_41
Brough (ref_83) 2011; 22
ref_102
Wu (ref_129) 2021; 100
Liu (ref_161) 2015; 3
ref_191
ref_192
Moore (ref_98) 2016; 45
Wang (ref_103) 2019; 10
Liu (ref_162) 2014; 3
Oh (ref_143) 2016; 45
Ashraf (ref_49) 2014; 54
Tarabees (ref_105) 2019; 11
References_xml – volume: 120
  start-page: 699
  year: 2021
  ident: ref_71
  article-title: Intestinal villus structure contributes to even shedding of epithelial cells
  publication-title: Biophys. J.
  doi: 10.1016/j.bpj.2021.01.003
– volume: 11
  start-page: 946
  year: 2019
  ident: ref_131
  article-title: Effects of the dietary probiotic, Enterococcus faecium NCIMB11181, on the intestinal barrier and system immune status in Escherichia coli O78-challenged broiler chickens
  publication-title: Probiotics Antimicrob. Proteins
  doi: 10.1007/s12602-018-9434-7
– ident: ref_151
  doi: 10.3390/antiox8070235
– volume: 13
  start-page: 356
  year: 2021
  ident: ref_159
  article-title: Analysis of miRNA expression in the ileum of broiler chickens during Bacillus licheniformis H2 supplementation against subclinical necrotic enteritis
  publication-title: Probiotics Antimicrob. Proteins
  doi: 10.1007/s12602-020-09709-9
– volume: 489
  start-page: 242
  year: 2012
  ident: ref_150
  article-title: Functional interactions between the gut microbiota and host metabolism
  publication-title: Nature
  doi: 10.1038/nature11552
– volume: 2018
  start-page: 7276523
  year: 2018
  ident: ref_128
  article-title: Effects of bile acids and nisin on the production of enterotoxin by Clostridium perfringens in a nutrient-rich medium
  publication-title: Int. J. Microbiol.
  doi: 10.1155/2018/7276523
– volume: 100
  start-page: 101358
  year: 2021
  ident: ref_45
  article-title: Effects of Bacillus subtilis and Bacillus licheniformis on growth performance, immunity, short chain fatty acid production, antioxidant capacity, and cecal microflora in broilers
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2021.101358
– ident: ref_192
  doi: 10.3390/microorganisms7050123
– volume: 101
  start-page: 101751
  year: 2022
  ident: ref_111
  article-title: The effects of feed supplementing Akkemansia muciniphila on incidence, severity, and gut microbiota of necrotic enteritis in chickens
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2022.101751
– volume: 40
  start-page: 990
  year: 2016
  ident: ref_181
  article-title: Antimicrobial activity of lactic acid against pathogen and spoilage microorganisms
  publication-title: J. Food Process. Preserv.
  doi: 10.1111/jfpp.12679
– volume: 107
  start-page: 111
  year: 2017
  ident: ref_1
  article-title: Environmental and human health challenges of industrial livestock and poultry farming in China and their mitigation
  publication-title: Environ. Int.
  doi: 10.1016/j.envint.2017.07.003
– ident: ref_41
  doi: 10.3390/ani9110985
– volume: 30
  start-page: 930
  year: 2006
  ident: ref_80
  article-title: Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick
  publication-title: Dev. Comp. Immunol.
  doi: 10.1016/j.dci.2005.12.002
– volume: 12
  start-page: 1385
  year: 2020
  ident: ref_55
  article-title: Benefit of dietary supplementation with Bacillus subtilis BYS2 on growth performance, immune response, and disease resistance of broilers
  publication-title: Probiotics Antimicrob. Proteins
  doi: 10.1007/s12602-020-09643-w
– volume: 22
  start-page: 189
  year: 2011
  ident: ref_83
  article-title: Understanding the mechanism of IL-1β secretion
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2011.10.001
– volume: 10
  start-page: 527
  year: 2020
  ident: ref_52
  article-title: Effects of Bacillus subtilis DSM 32315 on Immunity, nutrient transporters and functional diversity of cecal microbiome of broiler chickens in necrotic enteritis challenge
  publication-title: J. World’s Poult. Res.
  doi: 10.36380/jwpr.2020.61
– volume: 15
  start-page: 71
  year: 2015
  ident: ref_6
  article-title: The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: Current state
  publication-title: Nutr. J.
  doi: 10.1186/s12937-016-0186-5
– volume: 94
  start-page: 58
  year: 2011
  ident: ref_186
  article-title: Energy balance studies reveal associations between gut microbes, calorie load, and nutrient absorption in humans
  publication-title: Am. J. Clin. Nutr.
  doi: 10.3945/ajcn.110.010132
– volume: 98
  start-page: skz383
  year: 2020
  ident: ref_68
  article-title: Composition and inclusion of probiotics in broiler diets alter intestinal permeability and spleen immune cell profiles without negatively affecting performance
  publication-title: J. Anim. Sci.
  doi: 10.1093/jas/skz383
– volume: 101
  start-page: 101997
  year: 2022
  ident: ref_65
  article-title: Using combined Lactobacillus and quorum quenching enzyme supplementation as an antibiotic alternative to improve broiler growth performance, antioxidative status, immune response, and gut microbiota
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2022.101997
– volume: 70
  start-page: 3130
  year: 2002
  ident: ref_140
  article-title: Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.70.6.3130-3142.2002
– volume: 14
  start-page: 1110
  year: 2022
  ident: ref_13
  article-title: Effects of treatment with lactobacilli on necrotic enteritis in broiler chickens
  publication-title: Prob. Antimicrob. Proteins
  doi: 10.1007/s12602-021-09901-5
– volume: 7
  start-page: 1416
  year: 2016
  ident: ref_121
  article-title: The probiotic Butyricicoccus pullicaecorum reduces feed conversion and protects from potentially harmful intestinal microorganisms and necrotic enteritis in broilers
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2016.01416
– volume: 20
  start-page: 723
  year: 2014
  ident: ref_190
  article-title: Metabolic alterations to the mucosal microbiota in inflammatory bowel disease
  publication-title: Inflamm. Bowel Dis.
  doi: 10.1097/MIB.0000000000000011
– volume: 7
  start-page: 773
  year: 2021
  ident: ref_152
  article-title: Impacts of Microbial based Therapy on Growth Performance, Intestinal Health, Carcass Traits and Economic Efficiency of Clostridium perfringens-Infected Cobb and Arbor Acres Broilers
  publication-title: Vet. Med. Sci.
  doi: 10.1002/vms3.412
– volume: 223
  start-page: 157
  year: 2019
  ident: ref_30
  article-title: Anti-inflammatory and antioxidant activities of probiotic powder containing Lactobacillus plantarum 1.2567 in necrotic enteritis model of broiler chickens
  publication-title: Livest. Sci.
  doi: 10.1016/j.livsci.2019.03.009
– volume: 90
  start-page: 737
  year: 2019
  ident: ref_148
  article-title: The effects of the supplementation of multi-strain probiotics on intestinal microbiota, metabolites and inflammation of young SPF chickens challenged with Salmonella enterica subsp. enterica
  publication-title: Anim. Sci. J.
  doi: 10.1111/asj.13205
– ident: ref_39
  doi: 10.3390/ani12223085
– volume: 9
  start-page: 030
  year: 2019
  ident: ref_46
  article-title: Assessment of probiotic-supplementation on growth performance, lipid peroxidation, antioxidant capacity, and cecal microflora in broiler chickens
  publication-title: J. Appl. Pharm. Sci.
– volume: 102
  start-page: 102237
  year: 2023
  ident: ref_58
  article-title: Effects of Saccharomyces cerevisiae hydrolysate on growth performance, immunity function, and intestinal health in broilers
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2022.102237
– volume: 8
  start-page: 1592
  year: 2017
  ident: ref_70
  article-title: Probiotic enhanced intestinal immunity in broilers against subclinical necrotic enteritis
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.01592
– volume: 47
  start-page: 669
  year: 2012
  ident: ref_164
  article-title: Oral supplementation of butyrate reduces mucositis and intestinal permeability associated with 5-fluorouracil administration
  publication-title: Lipids
  doi: 10.1007/s11745-012-3680-3
– volume: 250
  start-page: 9
  year: 2019
  ident: ref_74
  article-title: Biomarkers of gastrointestinal functionality in animal nutrition and health
  publication-title: Anim. Feed Sci. Technol.
  doi: 10.1016/j.anifeedsci.2018.07.012
– volume: 1258
  start-page: 52
  year: 2012
  ident: ref_89
  article-title: Microbial butyrate and its role for barrier function in the gastrointestinal tract
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.2012.06553.x
– volume: 45
  start-page: 282
  year: 2016
  ident: ref_99
  article-title: Pathology and diagnosis of necrotic enteritis: Is it clear-cut?
  publication-title: Avian Pathol.
  doi: 10.1080/03079457.2016.1158780
– volume: 10
  start-page: 220
  year: 2020
  ident: ref_92
  article-title: Pretreatment with probiotics ameliorate gut health and necrotic enteritis in broiler chickens, a substitute to antibiotics
  publication-title: AMB Express
  doi: 10.1186/s13568-020-01153-w
– volume: 111
  start-page: 1394
  year: 2014
  ident: ref_106
  article-title: Dietary L-arginine supplementation attenuates lipopolysaccharide-induced inflammatory response in broiler chickens
  publication-title: Br. J. Nutr.
  doi: 10.1017/S0007114513003863
– volume: 9
  start-page: 1716
  year: 2018
  ident: ref_188
  article-title: Dietary L-arginine supplementation alleviates the intestinal injury and modulates the gut microbiota in broiler chickens challenged by Clostridium perfringens
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2018.01716
– volume: 97
  start-page: 2312
  year: 2018
  ident: ref_47
  article-title: Dietary effects of Bacillus subtilis fmbj on growth performance, small intestinal morphology, and its antioxidant capacity of broilers
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pey116
– volume: 20
  start-page: 2263
  year: 2021
  ident: ref_37
  article-title: Impact of probiotics and/or organic acids supplementation on growth performance, microbiota, antioxidative status, and immune response of broilers
  publication-title: Ital. J. Anim. Sci.
  doi: 10.1080/1828051X.2021.2012092
– volume: 3
  start-page: 187
  year: 2014
  ident: ref_162
  article-title: Heat shock proteins: Intestinal gatekeepers that are influenced by dietary components and the gut microbiota
  publication-title: Pathogens
  doi: 10.3390/pathogens3010187
– ident: ref_187
  doi: 10.1371/journal.pone.0002945
– volume: 69
  start-page: 621
  year: 2013
  ident: ref_155
  article-title: The applications of probiotics in poultry production
  publication-title: World’s Poult. Sci. J.
  doi: 10.1017/S0043933913000627
– volume: 109
  start-page: 31
  year: 2019
  ident: ref_166
  article-title: Molecular regulations of metabolism during immune response in insects
  publication-title: Insect Biochem. Mol. Biol
  doi: 10.1016/j.ibmb.2019.04.005
– ident: ref_153
  doi: 10.3390/microorganisms7030071
– volume: 98
  start-page: 4465
  year: 2019
  ident: ref_48
  article-title: Effect of dietary probiotics and prebiotics on the performance of broiler chickens
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pez282
– ident: ref_182
  doi: 10.3390/microorganisms10010152
– volume: 165
  start-page: 3951
  year: 2000
  ident: ref_163
  article-title: Exaggerated human monocyte IL-10 concomitant to minimal TNF-α induction by heat-shock protein 27 (Hsp27) suggests Hsp27 is primarily an antiinflammatory stimulus
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.165.7.3951
– volume: 6
  start-page: 114
  year: 2019
  ident: ref_147
  article-title: Differential effects of bacitracin methylene disalicylate (BMD) on the distal colon and cecal microbiota of young broiler chickens
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2019.00114
– volume: 7
  start-page: 170104
  year: 2017
  ident: ref_82
  article-title: AMP-activated protein kinase: A therapeutic target in intestinal diseases
  publication-title: Open Biol.
  doi: 10.1098/rsob.170104
– volume: 15
  start-page: 35
  year: 1995
  ident: ref_7
  article-title: Regulation of tight-junction permeability during nutrient absorption across the intestinal epithelium
  publication-title: Annu. Rev. Nutr.
  doi: 10.1146/annurev.nu.15.070195.000343
– volume: 153
  start-page: 1296
  year: 2008
  ident: ref_168
  article-title: Involvement of tumour necrosis factor-α in Clostridium perfringensβ-toxin-induced plasma extravasation in mice
  publication-title: Br. J. Pharm.
  doi: 10.1038/bjp.2008.9
– volume: 14
  start-page: 189
  year: 2014
  ident: ref_75
  article-title: Intestinal permeability—A new target for disease prevention and therapy
  publication-title: BMC Gastroenterol.
  doi: 10.1186/s12876-014-0189-7
– volume: 21
  start-page: 717
  year: 2022
  ident: ref_57
  article-title: Effects of dietary supplementation with Bacillus spp. and Debaryomyces spp. on broiler’s growth performance, serum characteristics, intestinal microflora and antioxidant activity
  publication-title: Ital. J. Anim. Sci.
  doi: 10.1080/1828051X.2022.2059022
– volume: 12
  start-page: 623739
  year: 2021
  ident: ref_19
  article-title: Probiotics Bacillus licheniformis improves intestinal health of subclinical necrotic enteritis-challenged broilers
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2021.623739
– volume: 8
  start-page: 2081
  year: 2017
  ident: ref_184
  article-title: Two Lactobacillus species inhibit the growth and α-toxin production of Clostridium perfringens and induced proinflammatory factors in chicken intestinal epithelial cells in vitro
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2017.02081
– volume: 97
  start-page: 2654
  year: 2018
  ident: ref_138
  article-title: Effect of dietary Bacillus coagulans supplementation on growth performance and immune responses of broiler chickens challenged by Salmonella enteritidis
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pey119
– volume: 97
  start-page: 2034
  year: 2018
  ident: ref_50
  article-title: Effects of Pediococcus acidilactici, mannan-oligosaccharide, butyric acid and their combination on growth performance and intestinal health in young broiler chickens challenged with Salmonella typhimurium
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pey035
– ident: ref_73
– ident: ref_32
  doi: 10.1371/journal.pone.0232781
– volume: 347
  start-page: 775
  year: 2015
  ident: ref_100
  article-title: Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin
  publication-title: Science
  doi: 10.1126/science.1261833
– ident: ref_116
  doi: 10.1007/s12602-021-09867-4
– volume: 8
  start-page: 65
  year: 2015
  ident: ref_4
  article-title: Efficacy of dietary antioxidants on broiler oxidative stress, performance and meat quality: Science and market
  publication-title: Avian Biol. Res.
  doi: 10.3184/175815515X14291701859483
– ident: ref_77
  doi: 10.1016/j.bj.2022.03.004
– ident: ref_165
  doi: 10.3390/cells8091075
– ident: ref_59
  doi: 10.1038/s41598-018-33762-8
– volume: 8
  start-page: 1865
  year: 2006
  ident: ref_5
  article-title: Redefining oxidative stress
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2006.8.1865
– ident: ref_158
  doi: 10.3390/microorganisms8050757
– volume: 100
  start-page: 101168
  year: 2021
  ident: ref_15
  article-title: Effects of Bacillus coagulans on growth performance, antioxidant capacity, immunity function, and gut health in broilers
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2021.101168
– volume: 45
  start-page: 275
  year: 2016
  ident: ref_98
  article-title: Necrotic enteritis predisposing factors in broiler chickens
  publication-title: Avian Pathol.
  doi: 10.1080/03079457.2016.1150587
– volume: 4
  start-page: 2610
  year: 2013
  ident: ref_130
  article-title: Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
  publication-title: Nat. Comm.
  doi: 10.1038/ncomms3610
– volume: 2016
  start-page: 4893501
  year: 2016
  ident: ref_134
  article-title: Concomitant prevalence of low serum diamine oxidase activity and carbohydrate malabsorption
  publication-title: Can. J. Gastroenterol. Hepatol.
  doi: 10.1155/2016/4893501
– volume: 33
  start-page: 1797
  year: 2020
  ident: ref_132
  article-title: Effects of multi-strain probiotic supplementation on intestinal microbiota, tight junctions, and inflammation in young broiler chickens challenged with Salmonella enterica subsp. enterica
  publication-title: Asian-Australas. J. Anim. Sci.
  doi: 10.5713/ajas.19.0427
– volume: 116
  start-page: 1878
  year: 2016
  ident: ref_142
  article-title: Dietary live yeast and mannan-oligosaccharide supplementation attenuate intestinal inflammation and barrier dysfunction induced by Escherichia coli in broilers
  publication-title: Br. J. Nutr.
  doi: 10.1017/S0007114516004116
– volume: 7
  start-page: 139
  year: 2017
  ident: ref_123
  article-title: Preventing subclinical necrotic enteritis through Lactobacillus johnsonii BS15 by ameliorating lipid metabolism and intestinal microflora in broiler chickens
  publication-title: AMB Express
  doi: 10.1186/s13568-017-0439-5
– volume: 18
  start-page: 112
  year: 2019
  ident: ref_170
  article-title: Probiotics isolated from yaks improves the growth performance, antioxidant activity, and cytokines related to immunity and inflammation in mice
  publication-title: Microb. Cell Factories
  doi: 10.1186/s12934-019-1161-6
– volume: 2021
  start-page: 2549541
  year: 2021
  ident: ref_28
  article-title: Supplemental Bacillus subtilis PB6 improves growth performance and gut health in broilers challenged with Clostridium perfringens
  publication-title: J. Immunol. Res.
  doi: 10.1155/2021/2549541
– ident: ref_86
  doi: 10.1371/journal.ppat.1005902
– volume: 103
  start-page: 1039
  year: 2019
  ident: ref_20
  article-title: Bacillus subtilis B21 and Bacillus licheniformis B26 improve intestinal health and performance of broiler chickens with Clostridium perfringens-induced necrotic enteritis
  publication-title: J. Anim. Physiol. Anim. Nutr.
  doi: 10.1111/jpn.13082
– volume: 9
  start-page: e12538
  year: 2021
  ident: ref_72
  article-title: Effects of probiotic supplements on growth performance and intestinal microbiota of partridge shank broiler chicks
  publication-title: Peer J.
  doi: 10.7717/peerj.12538
– volume: 101
  start-page: 101412
  year: 2022
  ident: ref_36
  article-title: Effects of novel microecologics combined with traditional Chinese medicine and probiotics on growth performance and health of broilers
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2021.101412
– volume: 100
  start-page: 100981
  year: 2021
  ident: ref_122
  article-title: Probiotic Bacillus subtilis 29,784 improved weight gain and enhanced gut health status of broilers under necrotic enteritis condition
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2021.01.004
– volume: 221
  start-page: 323
  year: 2016
  ident: ref_178
  article-title: Interaction between chicken intestinal microbiota and protein digestion
  publication-title: Anim. Feed Sci. Technol.
  doi: 10.1016/j.anifeedsci.2016.05.004
– volume: 21
  start-page: 8787
  year: 2015
  ident: ref_176
  article-title: Role of the normal gut microbiota
  publication-title: World J. Gastroenterol. WJG
  doi: 10.3748/wjg.v21.i29.8787
– volume: 71
  start-page: 103
  year: 2007
  ident: ref_183
  article-title: Evaluation in vitro of the antagonistic substances produced by Lactobacillus spp. isolated from chickens
  publication-title: Can. J. Vet. Res.
– volume: 100
  start-page: 302
  year: 2021
  ident: ref_118
  article-title: Characterization of a novel bacteriophage φCJ22 and its prophylactic and inhibitory effects on necrotic enteritis and Clostridium perfringens in broilers
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2020.10.019
– volume: 9
  start-page: 49
  year: 2018
  ident: ref_114
  article-title: Probiotic Lactobacillus johnsonii BS15 improves blood parameters related to immunity in broilers experimentally infected with subclinical necrotic enteritis
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2018.00049
– volume: 99
  start-page: 214
  year: 2020
  ident: ref_29
  article-title: Effects of Paenibacillus xylanexedens on growth performance, intestinal histomorphology, intestinal microflora, and immune response in broiler chickens challenged with Escherichia coli K88
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pez460
– volume: 13
  start-page: 191
  year: 2015
  ident: ref_108
  article-title: Salmonellae interactions with host processes
  publication-title: Nat. Rev. Microb.
  doi: 10.1038/nrmicro3420
– volume: 124
  start-page: 777
  year: 1998
  ident: ref_139
  article-title: Respiratory syncytial virus and human bronchial epithelium
  publication-title: Arch. Otolaryngol. Head Neck Surg.
  doi: 10.1001/archotol.124.7.777
– volume: 12
  start-page: 883
  year: 2020
  ident: ref_109
  article-title: Dietary probiotic Bacillus licheniformis H2 enhanced growth performance, morphology of small intestine and liver, and antioxidant capacity of broiler chickens against Clostridium perfringens–induced subclinical necrotic enteritis
  publication-title: Probiotics Antimicrob. Proteins
  doi: 10.1007/s12602-019-09597-8
– volume: 98
  start-page: 4391
  year: 2019
  ident: ref_124
  article-title: Bacillus amyloliquefaciens CECT 5940 alone or in combination with antibiotic growth promoters improves performance in broilers under enteric pathogen challenge
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pez223
– volume: 34
  start-page: 260
  year: 2016
  ident: ref_146
  article-title: Effects of antibiotics on gut microbiota
  publication-title: Dig. Dis.
  doi: 10.1159/000443360
– ident: ref_38
  doi: 10.3390/biology11050633
– volume: 57
  start-page: 3830
  year: 2017
  ident: ref_76
  article-title: Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective
  publication-title: Crit. Rev. Food Sci. Nutr.
  doi: 10.1080/10408398.2016.1152230
– volume: 54
  start-page: 938
  year: 2014
  ident: ref_49
  article-title: Immune system stimulation by probiotic microorganisms
  publication-title: Crit. Rev. Food Sci. Nutr.
  doi: 10.1080/10408398.2011.619671
– volume: 7
  start-page: 1
  year: 2018
  ident: ref_96
  article-title: An update on the human and animal enteric pathogen Clostridium perfringens
  publication-title: Emerg. Microbes Infect.
  doi: 10.1038/s41426-018-0144-8
– ident: ref_63
  doi: 10.3390/ani11123607
– ident: ref_69
  doi: 10.1186/s40104-022-00683-6
– volume: 9
  start-page: 25
  year: 2018
  ident: ref_125
  article-title: Effects of Lactobacillus acidophilus on the growth performance and intestinal health of broilers challenged with Clostridium perfringens
  publication-title: J. Anim. Sci. Biotechnol.
  doi: 10.1186/s40104-018-0243-3
– volume: 182
  start-page: 375
  year: 2013
  ident: ref_16
  article-title: Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2012.10.014
– volume: 40
  start-page: 341
  year: 2011
  ident: ref_107
  article-title: Necrotic enteritis in broilers: An updated review on the pathogenesis
  publication-title: Avian Pathol.
  doi: 10.1080/03079457.2011.590967
– ident: ref_136
  doi: 10.1590/rbz4820170298
– volume: 99
  start-page: 996
  year: 2002
  ident: ref_179
  article-title: Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater
  publication-title: Proc. Nat. Acad. Sci. USA
  doi: 10.1073/pnas.022493799
– volume: 99
  start-page: 725
  year: 2020
  ident: ref_127
  article-title: The effects of dietary Bacillus subtilis supplementation, as an alternative to antibiotics, on growth performance, intestinal immunity, and epithelial barrier integrity in broiler chickens infected with Eimeria maxima
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2019.12.002
– volume: 58
  start-page: 635
  year: 2017
  ident: ref_141
  article-title: Bacillus subtilis and yeast cell wall improve the intestinal health of broilers challenged by Clostridium perfringens
  publication-title: Br. Poult. Sci.
  doi: 10.1080/00071668.2017.1370697
– volume: 12
  start-page: 723187
  year: 2021
  ident: ref_95
  article-title: Bacillus subtilis DSM29784 alleviates negative effects on growth performance in broilers by improving the intestinal health under necrotic enteritis challenge
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2021.723187
– volume: 99
  start-page: 331
  year: 2020
  ident: ref_17
  article-title: A novel Bacillus based multi-strain probiotic improves growth performance and intestinal properties of Clostridium perfringens challenged broilers
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pez496
– volume: 9
  start-page: 1953
  year: 2018
  ident: ref_24
  article-title: Probiotic Lactobacillus plantarum promotes intestinal barrier function by strengthening the epithelium and modulating gut microbiota
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2018.01953
– ident: ref_54
  doi: 10.3389/fnut.2021.786878
– volume: 99
  start-page: 2452
  year: 2020
  ident: ref_137
  article-title: Research Note: Effect of synbiotic supplementation on caecal Clostridium perfringens load in broiler chickens with different necrotic enteritis challenge models
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2019.10.081
– ident: ref_44
  doi: 10.1007/s12602-022-09924-6
– volume: 122
  start-page: 3589
  year: 2009
  ident: ref_172
  article-title: mTOR signaling at a glance
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.051011
– ident: ref_62
  doi: 10.3390/antibiotics10111427
– volume: 100
  start-page: 101055
  year: 2021
  ident: ref_53
  article-title: Managing broilers gut health with antibiotic-free diets during subclinical necrotic enteritis
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2021.101055
– volume: 139
  start-page: 103870
  year: 2020
  ident: ref_104
  article-title: Comparative effects of Bacillus subtilis and Bacillus licheniformis on live performance, blood metabolites and intestinal features in broiler inoculated with Salmonella infection during the finisher phase
  publication-title: Microb. Pathog.
  doi: 10.1016/j.micpath.2019.103870
– volume: 58
  start-page: 30
  year: 2021
  ident: ref_120
  article-title: Bacillus licheniformis-fermented products improve growth performance and intestinal gut morphology in broilers under Clostridium perfringens challenge
  publication-title: J. Poult. Sci
  doi: 10.2141/jpsa.0200010
– volume: 28
  start-page: 1194
  year: 2015
  ident: ref_9
  article-title: Consumption of oxidized soybean oil increased intestinal oxidative stress and affected intestinal immune variables in yellow-feathered broilers
  publication-title: Asian-Australas. J. Anim. Sci.
  doi: 10.5713/ajas.14.0924
– ident: ref_126
  doi: 10.1371/journal.pone.0188634
– volume: 187
  start-page: 1543
  year: 2005
  ident: ref_149
  article-title: A novel mechanism for desulfation of mucin: Identification and cloning of a mucin-desulfating glycosidase (sulfoglycosidase) from Prevotella strain RS2
  publication-title: J. Bacteriol.
  doi: 10.1128/JB.187.5.1543-1551.2005
– volume: 98
  start-page: 1403
  year: 2019
  ident: ref_42
  article-title: Bacillus amyloliquefaciens spray improves the growth performance, immune status, and respiratory mucosal barrier in broiler chickens
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pey478
– volume: 8
  start-page: 679368
  year: 2021
  ident: ref_67
  article-title: Effects of Bacillus amyloliquefaciens instead of antibiotics on growth performance, intestinal health, and intestinal microbiota of broilers
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2021.679368
– volume: 8
  start-page: 680742
  year: 2021
  ident: ref_33
  article-title: Dietary Lactobacillus fermentum and Bacillus coagulans supplementation modulates intestinal immunity and microbiota of broiler chickens challenged by Clostridium perfringens
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2021.680742
– ident: ref_94
  doi: 10.3390/microorganisms7080231
– volume: 106
  start-page: 6441
  year: 2022
  ident: ref_185
  article-title: Lactobacillus casei displaying Clostridium perfringens NetB antigen protects chickens against necrotic enteritis
  publication-title: Appl. Microbiol. Biotechnol.
– ident: ref_61
  doi: 10.3390/ani12091086
– ident: ref_91
  doi: 10.3390/microorganisms7080257
– volume: 101
  start-page: 3015
  year: 2017
  ident: ref_14
  article-title: Bacillus amyloliquefaciens SC06 alleviates the oxidative stress of IPEC-1 via modulating Nrf2/Keap1 signaling pathway and decreasing ROS production
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-016-8032-4
– volume: 98
  start-page: 5392
  year: 2019
  ident: ref_117
  article-title: Effect of Bacillus subtilis DSM 32315 on the intestinal structural integrity and growth performance of broiler chickens under necrotic enteritis challenge
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pez368
– volume: 6
  start-page: 60
  year: 2019
  ident: ref_2
  article-title: Oxidative stress in the poultry gut: Potential challenges and interventions
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2019.00060
– volume: 98
  start-page: 188
  year: 2019
  ident: ref_85
  article-title: Characterization of intestinal immune response to Clostridium perfringens infection in broiler chickens
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pey390
– volume: 30
  start-page: 93
  year: 2020
  ident: ref_173
  article-title: Los probióticos y sus metabolitos en la acuicultura. Una Revisión The probiotics and their metabolites in aquaculture. A review
  publication-title: Hidrobiológica
– volume: 102
  start-page: 1232
  year: 2018
  ident: ref_119
  article-title: Optimization of surfactin production from Bacillus subtilis in fermentation and its effects on Clostridium perfringens-induced necrotic enteritis and growth performance in broilers
  publication-title: J. Anim. Physiol. Anim. Nutr.
  doi: 10.1111/jpn.12937
– volume: 67
  start-page: 4111
  year: 2001
  ident: ref_180
  article-title: Ruminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human feces
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.67.9.4111-4118.2001
– volume: 9
  start-page: 10256
  year: 2019
  ident: ref_112
  article-title: Pretreatment with probiotic Enterococcus faecium NCIMB 11181 ameliorates necrotic enteritis-induced intestinal barrier injury in broiler chickens
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-46578-x
– ident: ref_25
  doi: 10.1186/s40104-017-0220-2
– volume: 6
  start-page: 108
  year: 2019
  ident: ref_21
  article-title: Impact of a Bacillus direct-fed microbial on growth performance, intestinal barrier integrity, necrotic enteritis lesions, and ileal microbiota in broiler chickens using a laboratory challenge model
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2019.00108
– volume: 13
  start-page: 855426
  year: 2022
  ident: ref_12
  article-title: Dietary Probiotic Supplementation Suppresses Subclinical Necrotic Enteritis in Broiler Chickens in a Microbiota-Dependent Manner
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2022.855426
– volume: 21
  start-page: 1642
  year: 2022
  ident: ref_66
  article-title: The effect of probiotic and fermented soybean meal based on Bacillus subtilis spore on growth performance, gut morphology, immune response and dry matter digestibility in broiler chickens
  publication-title: Ital. J. Anim. Sci.
  doi: 10.1080/1828051X.2022.2148577
– volume: 13
  start-page: 19
  year: 2013
  ident: ref_79
  article-title: Mucosal immunology and probiotics
  publication-title: Curr. Allergy Asthma Rep.
  doi: 10.1007/s11882-012-0313-0
– volume: 12
  start-page: 4152
  year: 2022
  ident: ref_60
  article-title: Feeding Bacillus subtilis ATCC19659 to broiler chickens enhances growth performance and immune function by modulating intestinal morphology and cecum microbiota
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2021.798350
– volume: 101
  start-page: 101912
  year: 2022
  ident: ref_40
  article-title: Effect of novel Lactobacillus paracaesi microcapsule on growth performance, gut health and microbiome community of broiler chickens
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2022.101912
– ident: ref_191
  doi: 10.3390/genes8120350
– volume: 11
  start-page: 981
  year: 2019
  ident: ref_105
  article-title: Effects of dietary supplementation of probiotic mix and prebiotic on growth performance, cecal microbiota composition, and protection against Escherichia coli O78 in broiler chickens
  publication-title: Probiotics Antimicrob. Proteins
  doi: 10.1007/s12602-018-9459-y
– volume: 97
  start-page: 1238
  year: 2018
  ident: ref_8
  article-title: Vitamin E and vitamin C supplementation improves antioxidant status and immune function in oxidative-stressed breeder roosters by up-regulating expression of GSH-Px gene
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pex417
– ident: ref_43
  doi: 10.21203/rs.3.rs-2292982/v1
– volume: 62
  start-page: 1090
  year: 2021
  ident: ref_93
  article-title: Probiotics and gut health: Linking gut homeostasis and poultry productivity
  publication-title: Anim. Prod. Sci.
  doi: 10.1071/AN20701
– ident: ref_10
  doi: 10.3390/toxins9020060
– volume: 130
  start-page: 396S
  year: 2000
  ident: ref_174
  article-title: The role of probiotic cultures in the control of gastrointestinal health
  publication-title: J. Nutr.
  doi: 10.1093/jn/130.2.396S
– volume: 98
  start-page: 3450
  year: 2019
  ident: ref_113
  article-title: The impact of Bacillus subtilis DSM 32315 on the pathology, performance, and intestinal microbiome of broiler chickens in a necrotic enteritis challenge
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pey500
– volume: 100
  start-page: 101323
  year: 2021
  ident: ref_129
  article-title: Effects of Lactobacillus acidophilus on the growth performance, immune response, and intestinal barrier function of broiler chickens challenged with Escherichia coli O157
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2021.101323
– volume: 3
  start-page: 71
  year: 2016
  ident: ref_88
  article-title: Gut health: The new paradigm in food animal production
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2016.00071
– volume: 638
  start-page: 128
  year: 2010
  ident: ref_169
  article-title: Protective effects of imipramine in murine endotoxin-induced acute lung injury
  publication-title: Eur. J. Pharm.
  doi: 10.1016/j.ejphar.2010.04.005
– volume: 5
  start-page: 16387
  year: 2015
  ident: ref_3
  article-title: The genetics of feed conversion efficiency traits in a commercial broiler line
  publication-title: Sci. Rep.
  doi: 10.1038/srep16387
– volume: 7
  start-page: 24
  year: 2021
  ident: ref_35
  article-title: The impact of probiotics on gut health via alternation of immune status of monogastric animals
  publication-title: Anim. Nutr.
  doi: 10.1016/j.aninu.2020.11.004
– volume: 205
  start-page: 21
  year: 2015
  ident: ref_34
  article-title: The use of antimicrobial agents in broiler chickens
  publication-title: Vet. J.
  doi: 10.1016/j.tvjl.2015.04.016
– volume: 97
  start-page: 510
  year: 2018
  ident: ref_78
  article-title: Inflammation: Friend or foe for animal production?
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pex314
– volume: 10
  start-page: 1681
  year: 2019
  ident: ref_103
  article-title: Supplemental plant extracts from flos lonicerae in combination with baikal skullcap attenuate intestinal disruption and modulate gut microbiota in laying hens challenged by Salmonella pullorum
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2019.01681
– volume: 7
  start-page: 572142
  year: 2020
  ident: ref_23
  article-title: Effect of probiotics and multi-component feed additives on microbiota, gut barrier and immune responses in broiler chickens during subclinical necrotic enteritis
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2020.572142
– volume: 92
  start-page: 370
  year: 2013
  ident: ref_160
  article-title: Bacillus subtilis PB6 improves intestinal health of broiler chickens challenged with Clostridium perfringens-induced necrotic enteritis
  publication-title: Poult. Sci.
  doi: 10.3382/ps.2012-02528
– volume: 9
  start-page: 1223
  year: 2019
  ident: ref_167
  article-title: IL-10 produced by macrophages regulates epithelial integrity in the small intestine
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-38125-x
– volume: 43
  start-page: 74
  year: 2012
  ident: ref_97
  article-title: The successful experimental induction of necrotic enteritis in chickens by Clostridium perfringens: A critical review
  publication-title: Vet. Res.
  doi: 10.1186/1297-9716-43-74
– volume: 8
  start-page: 1744
  year: 2018
  ident: ref_145
  article-title: Bacillus licheniformis normalize the ileum microbiota of chickens infected with necrotic enteritis
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-20059-z
– volume: 11
  start-page: 299
  year: 2020
  ident: ref_27
  article-title: Clostridium butyricum ameliorates Salmonella enteritis induced inflammation by enhancing and improving immunity of the intestinal epithelial barrier at the intestinal mucosal level
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2020.00299
– volume: 11
  start-page: 137
  year: 2016
  ident: ref_81
  article-title: B cells, antibodies, and more
  publication-title: Clin. J. Am. Soc. Nephrol.
  doi: 10.2215/CJN.09430915
– volume: 45
  start-page: 313
  year: 2016
  ident: ref_143
  article-title: The role of host genetic factors and host immunity in necrotic enteritis
  publication-title: Avian Pathol.
  doi: 10.1080/03079457.2016.1154503
– volume: 89
  start-page: 895
  year: 2018
  ident: ref_115
  article-title: Effects of the butyric acid-producing strain Clostridium butyricum MIYAIRI 588 on broiler and piglet zootechnical performance and prevention of necrotic enteritis
  publication-title: Anim. Sci. J.
  doi: 10.1111/asj.13006
– volume: 7
  start-page: 185
  year: 2021
  ident: ref_11
  article-title: Bacillus amyloliquefaciens CECT 5940 improves performance and gut function in broilers fed different levels of protein and/or under necrotic enteritis challenge
  publication-title: Anim. Nutr.
  doi: 10.1016/j.aninu.2020.05.004
– volume: 360
  start-page: 100
  year: 2014
  ident: ref_87
  article-title: The chicken gastrointestinal microbiome
  publication-title: FEMS Microbiol. Lett.
  doi: 10.1111/1574-6968.12608
– volume: 136
  start-page: 96
  year: 2019
  ident: ref_157
  article-title: Gut microbiota modulation and anti-inflammatory properties of anthocyanins from the fruits of Lycium ruthenicum Murray in dextran sodium sulfate-induced colitis in mice
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2019.04.005
– volume: 12
  start-page: 39
  year: 1993
  ident: ref_175
  article-title: Genetics of bacteriocins produced by lactic acid bacteria
  publication-title: FEMS Microbiol. Rev.
  doi: 10.1016/0168-6445(93)90057-G
– ident: ref_22
  doi: 10.3390/ani10030507
– ident: ref_90
  doi: 10.1371/journal.pone.0182426
– volume: 15
  start-page: 229
  year: 2006
  ident: ref_154
  article-title: Effect of Bacillus subtilis PB6 (CloSTAT) on broilers infected with a pathogenic strain of Escherichia coli
  publication-title: J. Appl. Poult. Res.
  doi: 10.1093/japr/15.2.229
– ident: ref_51
  doi: 10.1186/s13568-019-0914-2
– volume: 14
  start-page: 361
  year: 2003
  ident: ref_84
  article-title: The biology of IL-12: Coordinating innate and adaptive immune responses
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/S1359-6101(03)00043-1
– ident: ref_110
  doi: 10.1007/s12602-021-09853-w
– volume: 95
  start-page: 1888
  year: 2016
  ident: ref_101
  article-title: Prevalence and antibiotic resistance of Salmonella Enteritidis and Salmonella Typhimurium in raw chicken meat at retail markets in Malaysia
  publication-title: Poult. Sci.
  doi: 10.3382/ps/pew144
– volume: 122
  start-page: 347
  year: 2017
  ident: ref_189
  article-title: Phylogenetic and functional characterization of the distal intestinal microbiome of rainbow trout Oncorhynchus mykiss from both farm and aquarium settings
  publication-title: J. Appl. Microbiol.
  doi: 10.1111/jam.13347
– volume: 10
  start-page: 2309
  year: 2019
  ident: ref_26
  article-title: The effect of Clostridium butyricum on gut microbiota, immune response and intestinal barrier function during the development of necrotic enteritis in chickens
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2019.02309
– volume: 1
  start-page: 11
  year: 2008
  ident: ref_144
  article-title: The immune geography of IgA induction and function
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2007.6
– volume: 7
  start-page: 8252
  year: 2017
  ident: ref_133
  article-title: The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-07958-3
– volume: 3
  start-page: e12355
  year: 2015
  ident: ref_161
  article-title: Effects of Lactobacillus johnsonii and Lactobacillus reuteri on gut barrier function and heat shock proteins in intestinal porcine epithelial cells
  publication-title: Physiol. Rep.
  doi: 10.14814/phy2.12355
– volume: 66
  start-page: 1027
  year: 2016
  ident: ref_177
  article-title: Characterization and in vitro properties of potential probiotic Bifidobacterium strains isolated from breast-fed infant feces
  publication-title: Ann. Microbiol.
  doi: 10.1007/s13213-015-1187-x
– volume: 50
  start-page: e450
  year: 2018
  ident: ref_135
  article-title: Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
  publication-title: Exp. Mol. Med.
  doi: 10.1038/emm.2017.282
– ident: ref_102
  doi: 10.1371/journal.pbio.0040349
– volume: 94
  start-page: 486
  year: 2010
  ident: ref_156
  article-title: Effect of addition of a probiotic micro-organism to broiler diet on intestinal mucosal architecture and electrophysiological parameters
  publication-title: J. Anim. Physiol. Anim. Nutr.
  doi: 10.1111/j.1439-0396.2009.00933.x
– volume: 101
  start-page: 101585
  year: 2022
  ident: ref_64
  article-title: Effects of dietary Bacillus amyloliquefaciens CECT 5940 supplementation on growth performance, antioxidant status, immunity, and digestive enzyme activity of broilers fed corn-wheat-soybean meal diets
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2021.101585
– volume: 100
  start-page: 100982
  year: 2021
  ident: ref_18
  article-title: Effects of feed supplementation with 3 different probiotic Bacillus strains and their combination on the performance of broiler chickens challenged with Clostridium perfringens
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2021.01.005
– volume: 99
  start-page: 4278
  year: 2020
  ident: ref_31
  article-title: Probiotic Bacillus amyloliquefaciens H57 ameliorates subclinical necrotic enteritis in broiler chicks by maintaining intestinal mucosal integrity and improving feed efficiency
  publication-title: Poult. Sci.
  doi: 10.1016/j.psj.2020.05.034
– volume: 13
  start-page: 914212
  year: 2022
  ident: ref_56
  article-title: Functional comparison of Clostridium butyricum and sodium butyrate supplementation on growth, intestinal health, and the anti-inflammatory response of broilers
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2022.914212
– volume: 60
  start-page: 784
  year: 2019
  ident: ref_171
  article-title: Effects of low-dose oleuropein diet supplementation on the oxidative status of skeletal muscles and plasma hormonal concentration of growing broiler chickens
  publication-title: Br. Poult. Sci.
  doi: 10.1080/00071668.2019.1662886
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Snippet Gut health includes normal intestinal physiology, complete intestinal epithelial barrier, efficient immune response, sustained inflammatory balance, healthy...
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SubjectTerms adhesion
antibiotics
Antioxidants
Apoptosis
Bacteriocins
biosecurity
broilers
Broilers (Poultry)
competitive exclusion
Cytokines
death
Digestive system
Disease
Endotoxins
Energy balance
Energy metabolism
Enteritis
Enzymes
Food security
Gastrointestinal tract
growth performance
gut health
Health aspects
Homeostasis
Immune response
Immunoglobulins
Inflammation
Intestinal microflora
intestinal microorganisms
intestinal mucosa
Intestine
metabolites
Microbiomes
Microbiota
Morphology
Mortality
necrotic enteritis
nutrient uptake
Nutrient utilization
Nutrients
Oxidative stress
Pathogens
Permeability
Physiology
Poultry
poultry production
Probiotics
Protein structure
Protein transport
Proteins
Review
secretion
Small intestine
therapeutics
tight junctions
Trends
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Title Recent Trends on Mitigative Effect of Probiotics on Oxidative-Stress-Induced Gut Dysfunction in Broilers under Necrotic Enteritis Challenge: A Review
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Volume 12
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