GC–MS analysis of the designer drug α-pyrrolidinovalerophenone and its metabolites in urine and blood in an acute poisoning case

• Published in: Forensic science international Vol. 259; pp. e14 - e19
• Main Authors: Grapp, Marcel, Sauer, Christoph, Vidal, Christian, Müller, Dieter
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.02.2016
• Subjects: Acute Disease; Adult; Delirium - blood; Delirium - chemically induced; Delirium - urine; Designer drug; Designer Drugs - analysis; Gas chromatography; Gas Chromatography-Mass Spectrometry; General unknown screening; Humans; Liquid-liquid extraction; Male; Mass spectrometry; Metabolites; Pathology; Poisoning; Pyrrolidines - blood; Pyrrolidines - poisoning; Pyrrolidines - urine; Pyrrolidinophenone; Screening; Serums; Urine; α-Pyrrolidinovalerophenone; Pyrrolidinophenone; Designer drug; Gas chromatography–mass spectrometry; α-Pyrrolidinovalerophenone; General unknown screening

•We report a case of severe poisoning with α-pyrrolidinovalerophenone (α-PVP).•α-PVP and its 2″-oxo-metabolite were identified in urine by GC–MS.•The concentration of α-PVP was determined in serum.•The presented data were linked to the clinical condition excited delirium syndrome. α-Pyrrolidinovaler...