Open questions in the study of de novo genes: what, how and why
In this Opinion article, the authors discuss important questions relating to the study of de novo genes. They discuss the challenges of identifying de novo genes, understanding how they originate and why they spread, and propose that antagonistic evolution may have a key role in their evolution. The...
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| Published in | Nature reviews. Genetics Vol. 17; no. 9; pp. 567 - 578 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.09.2016
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | In this Opinion article, the authors discuss important questions relating to the study of
de novo
genes. They discuss the challenges of identifying
de novo
genes, understanding how they originate and why they spread, and propose that antagonistic evolution may have a key role in their evolution.
The study of
de novo
protein-coding genes is maturing from the
ad hoc
reporting of individual cases to the systematic analysis of extensive genomic data from several species. We identify three key challenges for this emerging field: understanding how best to identify
de novo
genes, how they arise and why they spread. We highlight the intellectual challenges of understanding how a
de novo
gene becomes integrated into pre-existing functions and becomes essential. We suggest that, as with protein sequence evolution, antagonistic co-evolution may be key to
de novo
gene evolution, particularly for new essential genes and new cancer-associated genes. |
|---|---|
| AbstractList | In this Opinion article, the authors discuss important questions relating to the study of
de novo
genes. They discuss the challenges of identifying
de novo
genes, understanding how they originate and why they spread, and propose that antagonistic evolution may have a key role in their evolution.
The study of
de novo
protein-coding genes is maturing from the
ad hoc
reporting of individual cases to the systematic analysis of extensive genomic data from several species. We identify three key challenges for this emerging field: understanding how best to identify
de novo
genes, how they arise and why they spread. We highlight the intellectual challenges of understanding how a
de novo
gene becomes integrated into pre-existing functions and becomes essential. We suggest that, as with protein sequence evolution, antagonistic co-evolution may be key to
de novo
gene evolution, particularly for new essential genes and new cancer-associated genes. The study of de novo protein-coding genes is maturing from the ad hoc reporting of individual cases to the systematic analysis of extensive genomic data from several species. We identify three key challenges for this emerging field: understanding how best to identify de novo genes, how they arise and why they spread. We highlight the intellectual challenges of understanding how a de novo gene becomes integrated into pre-existing functions and becomes essential. We suggest that, as with protein sequence evolution, antagonistic co-evolution may be key to de novo gene evolution, particularly for new essential genes and new cancer-associated genes. |
| Audience | Academic |
| Author | Hurst, Laurence D. McLysaght, Aoife |
| Author_xml | – sequence: 1 givenname: Aoife surname: McLysaght fullname: McLysaght, Aoife email: aoife.mclysaght@tcd.ie organization: The Smurfit Institute of Genetics, University of Dublin, Trinity College – sequence: 2 givenname: Laurence D. surname: Hurst fullname: Hurst, Laurence D. organization: Department of Biology and Biochemistry, The Milner Centre for Evolution, University of Bath |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27452112$$D View this record in MEDLINE/PubMed |
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| Snippet | In this Opinion article, the authors discuss important questions relating to the study of
de novo
genes. They discuss the challenges of identifying
de novo... The study of de novo protein-coding genes is maturing from the ad hoc reporting of individual cases to the systematic analysis of extensive genomic data from... |
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| Title | Open questions in the study of de novo genes: what, how and why |
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