Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals
The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become viru...
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| Published in | Immunity (Cambridge, Mass.) Vol. 52; no. 6; pp. 971 - 977.e3 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
16.06.2020
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells. Our work provides a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It also has implications in developing an effective vaccine to SARS-CoV-2 infection.
•SARS-CoV-2-specific antibodies are detected in COVID-19 convalescent subjects•Most COVID-19 convalescent individuals have detectable neutralizing antibodies•Cellular immune responses to SARS-CoV-2 are found in COVID-19 convalescent subjects•Neutralization antibody titers correlate with the numbers of virus-specific T cells.
In blood samples from COVID-19 convalescent subjects, Ni et al. have detected SARS-CoV-2-specific humoral and cellular immunity. Most subjects display serum neutralizing activities, which correlate with the numbers of virus-specific T cells. |
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| AbstractList | The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells. Our work provides a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It also has implications in developing an effective vaccine to SARS-CoV-2 infection.The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells. Our work provides a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It also has implications in developing an effective vaccine to SARS-CoV-2 infection. The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells. Our work provides a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It also has implications in developing an effective vaccine to SARS-CoV-2 infection. •SARS-CoV-2-specific antibodies are detected in COVID-19 convalescent subjects•Most COVID-19 convalescent individuals have detectable neutralizing antibodies•Cellular immune responses to SARS-CoV-2 are found in COVID-19 convalescent subjects•Neutralization antibody titers correlate with the numbers of virus-specific T cells. In blood samples from COVID-19 convalescent subjects, Ni et al. have detected SARS-CoV-2-specific humoral and cellular immunity. Most subjects display serum neutralizing activities, which correlate with the numbers of virus-specific T cells. The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells. Our work provides a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It also has implications in developing an effective vaccine to SARS-CoV-2 infection. The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells. Our work provides a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It also has implications in developing an effective vaccine to SARS-CoV-2 infection. • SARS-CoV-2-specific antibodies are detected in COVID-19 convalescent subjects • Most COVID-19 convalescent individuals have detectable neutralizing antibodies • Cellular immune responses to SARS-CoV-2 are found in COVID-19 convalescent subjects • Neutralization antibody titers correlate with the numbers of virus-specific T cells. In blood samples from COVID-19 convalescent subjects, Ni et al. have detected SARS-CoV-2-specific humoral and cellular immunity. Most subjects display serum neutralizing activities, which correlate with the numbers of virus-specific T cells. SummaryThe World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells. Our work provides a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It also has implications in developing an effective vaccine to SARS-CoV-2 infection. |
| Author | Cheng, Meng-Li Ni, Ling Ye, Fang Zhao, Hui Deng, Yong-Qiang Zhou, Chao Liang, Peng Wang, Pengzhi Qin, Cheng-Feng Dong, Chen Ge, Jiwan Cao, Tianshu Guo, Han Wang, Xinquan Feng, Yu Chen, Fang Gou, Mengting Li, Xiaoli Wei, Peng Sun, Lin Zhang, Rongrong |
| Author_xml | – sequence: 1 givenname: Ling surname: Ni fullname: Ni, Ling organization: Institute for Immunology and School of Medicine, Tsinghua University, 100084 Beijing, China – sequence: 2 givenname: Fang surname: Ye fullname: Ye, Fang organization: Department of Hematology, Chui Yang Liu Hospital affiliated to Tsinghua University, 100022 Beijing, China – sequence: 3 givenname: Meng-Li surname: Cheng fullname: Cheng, Meng-Li organization: Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071 Beijing, China – sequence: 4 givenname: Yu surname: Feng fullname: Feng, Yu organization: Institute for Immunology and School of Medicine, Tsinghua University, 100084 Beijing, China – sequence: 5 givenname: Yong-Qiang surname: Deng fullname: Deng, Yong-Qiang organization: Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071 Beijing, China – sequence: 6 givenname: Hui surname: Zhao fullname: Zhao, Hui organization: Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071 Beijing, China – sequence: 7 givenname: Peng surname: Wei fullname: Wei, Peng organization: Institute for Immunology and School of Medicine, Tsinghua University, 100084 Beijing, China – sequence: 8 givenname: Jiwan surname: Ge fullname: Ge, Jiwan organization: School of Life Sciences, Tsinghua University, 100022 Beijing, China – sequence: 9 givenname: Mengting surname: Gou fullname: Gou, Mengting organization: Institute for Immunology and School of Medicine, Tsinghua University, 100084 Beijing, China – sequence: 10 givenname: Xiaoli surname: Li fullname: Li, Xiaoli organization: Institute for Immunology and School of Medicine, Tsinghua University, 100084 Beijing, China – sequence: 11 givenname: Lin surname: Sun fullname: Sun, Lin organization: Institute for Immunology and School of Medicine, Tsinghua University, 100084 Beijing, China – sequence: 12 givenname: Tianshu surname: Cao fullname: Cao, Tianshu organization: Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071 Beijing, China – sequence: 13 givenname: Pengzhi surname: Wang fullname: Wang, Pengzhi organization: Institute for Immunology and School of Medicine, Tsinghua University, 100084 Beijing, China – sequence: 14 givenname: Chao surname: Zhou fullname: Zhou, Chao organization: Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071 Beijing, China – sequence: 15 givenname: Rongrong surname: Zhang fullname: Zhang, Rongrong organization: Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071 Beijing, China – sequence: 16 givenname: Peng surname: Liang fullname: Liang, Peng organization: Department of Cardiology, Chui Yang Liu Hospital affiliated to Tsinghua University, 100022 Beijing, China – sequence: 17 givenname: Han surname: Guo fullname: Guo, Han organization: Department of Orthopedics, Chui Yang Liu Hospital affiliated to Tsinghua University, 100022 Beijing, China – sequence: 18 givenname: Xinquan surname: Wang fullname: Wang, Xinquan organization: School of Life Sciences, Tsinghua University, 100022 Beijing, China – sequence: 19 givenname: Cheng-Feng surname: Qin fullname: Qin, Cheng-Feng email: qincf@bmi.ac.cn organization: Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071 Beijing, China – sequence: 20 givenname: Fang surname: Chen fullname: Chen, Fang email: anzhenchenfang@163.com organization: Department of Cardiology, Chui Yang Liu Hospital affiliated to Tsinghua University, 100022 Beijing, China – sequence: 21 givenname: Chen surname: Dong fullname: Dong, Chen email: chendong@tsinghua.edu.cn organization: Institute for Immunology and School of Medicine, Tsinghua University, 100084 Beijing, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32413330$$D View this record in MEDLINE/PubMed |
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| Snippet | The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune... SummaryThe World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune... |
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| SubjectTerms | Adaptive immunity Adult Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Betacoronavirus - physiology Cell-mediated immunity Convalescence Coronavirus Infections - blood Coronavirus Infections - immunology Coronavirus Infections - pathology Coronaviruses COVID-19 COVID-19 patients Female Health care Humans Humoral immunity IgG antibody Immune response Immunity Immunity, Cellular Immunity, Humoral Immunoglobulin G Infections Lymphocytes Lymphocytes T Male Middle Aged Middle East respiratory syndrome Neutralization Pandemics Pathogenesis Patients Pneumonia, Viral - blood Pneumonia, Viral - immunology Pneumonia, Viral - pathology Proteins SARS-CoV-2 SARS-CoV-2-specific antibody SARS-CoV-2-specific T cells Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - immunology Vaccines Viral diseases Viruses |
| Title | Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals |
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