Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms

• Published in: Proceedings of the Nutrition Society Vol. 75; no. 1; pp. 47 - 60
• Main Authors: Rodriguez-Ramiro, I., Vauzour, D., Minihane, A. M.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.02.2016
• Subjects: Adipose tissue; AMP-activated protein kinase; anti-inflammatory activity; Antioxidants; beta oxidation; Bioactive compounds; cell culture; clinical trials; Cocoa; Conference on ‘Diet, gene regulation and metabolic disease’; fatty acids; fatty liver; Flavonoids; Fruits; humans; Hypertension; Insulin resistance; lipogenesis; liver; Liver cancer; Liver cirrhosis; Liver diseases; mechanism of action; metabolic diseases; Metabolic disorders; metabolic syndrome; Metabolites; obesity; Oxidation; Oxidative stress; Pathophysiology; phenotype; Polyphenols; risk reduction; Rodents; Symposium 2: Micronutrients, phytochemicals, gene expression and metabolic disease; therapeutics; Obesity; Insulin resistance; Flavonoids; PPARα; Sterol regulatory element-binding protein 1c; Steatosis; FA fatty acids; MCD methionine and choline deficiency; NASH non-alcoholic steatohepatitis; SIRT-1 sirtuin 1; CPT carnitine palmitoyl transferase 1; HSE Hibiscus sabdariffa L. extract; SREBP-1c sterol regulatory element-binding protein 1c; JNK c-Jun N-terminal kinase; NAFLD non-alcoholic fatty liver disease; Nrf2 nuclear factor-erythroid 2-related factor 2; HFD high fat diet; AMPK AMP-activated protein kinase

Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic component of the metabolic syndrome and its prevalence is rapidly increasing due to its strong association with insulin resistance and obesity. At present, given that NAFLD is highly prevalent and therapies are limited, much a...