potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 43; pp. 16761 - 16766
• Main Authors: Banin, Ehud, Lozinski, Alina, Brady, Keith M, Berenshtein, Eduard, Butterfield, Phillip W, Moshe, Maya, Chevion, Mordechai, Greenberg, Everett Peter, Banin, Eyal
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 28.10.2008; National Acad Sciences
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotics; Bacteria; Biofilms; Biofilms - drug effects; Biological Sciences; Cornea; Deferoxamine - pharmacology; Deferoxamine - therapeutic use; Drug therapy; Drug Therapy, Combination; Eye Infections, Bacterial - drug therapy; Eyes; Gallium; Gentamicins - pharmacology; Gentamicins - therapeutic use; Infections; Iron; Iron - metabolism; Keratitis; Pathogens; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas Infections - drug therapy; Rabbits; Treatment Outcome

The opportunistic pathogen Pseudomonas aeruginosa causes infections that are difficult to treat by antibiotic therapy. This bacterium can cause biofilm infections where it shows tolerance to antibiotics. Here we report the novel use of a metallo-complex, desferrioxamine-gallium (DFO-Ga) that targets...