Optimization of hyaluronan-based eye drop formulations
•Hydrodynamic and rheological evaluations of HA-based eye drops were achieved.•Most of commercial HA-based eye drops are not optimized.•Combinations of HA molecular weight/amount maximizing performance were determined.•Formulations expected to have maximized retention on ocular surface were develope...
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Published in | Carbohydrate polymers Vol. 153; pp. 275 - 283 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
20.11.2016
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Abstract | •Hydrodynamic and rheological evaluations of HA-based eye drops were achieved.•Most of commercial HA-based eye drops are not optimized.•Combinations of HA molecular weight/amount maximizing performance were determined.•Formulations expected to have maximized retention on ocular surface were developed.•Developed formulas show improved protection of corneal epithelium from dehydration.
Hyaluronan (HA) is frequently incorporated in eye drops to extend the pre-corneal residence time, due to its viscosifying and mucoadhesive properties. Hydrodynamic and rheological evaluations of commercial products are first accomplished revealing molecular weights varying from about 360 to about 1200kDa and viscosity values in the range 3.7–24.2mPa s. The latter suggest that most products could be optimized towards resistance to drainage from the ocular surface. Then, a study aiming to maximize the viscosity and mucoadhesiveness of HA-based preparations is performed. The effect of polymer chain length and concentration is investigated. For the whole range of molecular weights encountered in commercial products, the concentration maximizing performance is identified. Such concentration varies from 0.3 (wt%) for a 1100kDa HA up to 1.0 (wt%) for a 250kDa HA, which is 3-fold higher than the highest concentration on the market. The viscosity and mucoadhesion profiles of optimized formulations are superior than commercial products, especially under conditions simulating in vivo blinking. Thus longer retention on the corneal epithelium can be predicted. An enhanced capacity to protect corneal porcine epithelial cells from dehydration is also demonstrated in vitro. Overall, the results predict formulations with improved efficacy. |
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AbstractList | Hyaluronan (HA) is frequently incorporated in eye drops to extend the pre-corneal residence time, due to its viscosifying and mucoadhesive properties. Hydrodynamic and rheological evaluations of commercial products are first accomplished revealing molecular weights varying from about 360 to about 1200kDa and viscosity values in the range 3.7-24.2mPa s. The latter suggest that most products could be optimized towards resistance to drainage from the ocular surface. Then, a study aiming to maximize the viscosity and mucoadhesiveness of HA-based preparations is performed. The effect of polymer chain length and concentration is investigated. For the whole range of molecular weights encountered in commercial products, the concentration maximizing performance is identified. Such concentration varies from 0.3 (wt%) for a 1100kDa HA up to 1.0 (wt%) for a 250kDa HA, which is 3-fold higher than the highest concentration on the market. The viscosity and mucoadhesion profiles of optimized formulations are superior than commercial products, especially under conditions simulating in vivo blinking. Thus longer retention on the corneal epithelium can be predicted. An enhanced capacity to protect corneal porcine epithelial cells from dehydration is also demonstrated in vitro. Overall, the results predict formulations with improved efficacy. •Hydrodynamic and rheological evaluations of HA-based eye drops were achieved.•Most of commercial HA-based eye drops are not optimized.•Combinations of HA molecular weight/amount maximizing performance were determined.•Formulations expected to have maximized retention on ocular surface were developed.•Developed formulas show improved protection of corneal epithelium from dehydration. Hyaluronan (HA) is frequently incorporated in eye drops to extend the pre-corneal residence time, due to its viscosifying and mucoadhesive properties. Hydrodynamic and rheological evaluations of commercial products are first accomplished revealing molecular weights varying from about 360 to about 1200kDa and viscosity values in the range 3.7–24.2mPa s. The latter suggest that most products could be optimized towards resistance to drainage from the ocular surface. Then, a study aiming to maximize the viscosity and mucoadhesiveness of HA-based preparations is performed. The effect of polymer chain length and concentration is investigated. For the whole range of molecular weights encountered in commercial products, the concentration maximizing performance is identified. Such concentration varies from 0.3 (wt%) for a 1100kDa HA up to 1.0 (wt%) for a 250kDa HA, which is 3-fold higher than the highest concentration on the market. The viscosity and mucoadhesion profiles of optimized formulations are superior than commercial products, especially under conditions simulating in vivo blinking. Thus longer retention on the corneal epithelium can be predicted. An enhanced capacity to protect corneal porcine epithelial cells from dehydration is also demonstrated in vitro. Overall, the results predict formulations with improved efficacy. |
Author | Salzillo, Rosanna D’Agostino, Antonella Filosa, Rosanna Schiraldi, Chiara De Rosa, Mario Corsuto, Luisana La Gatta, Annalisa |
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Cites_doi | 10.1136/bjo.85.5.610 10.1016/j.carres.2005.01.022 10.1016/j.carbpol.2012.08.011 10.1586/17469899.2015.1015993 10.1016/j.ab.2010.04.014 10.1016/j.ijpharm.2010.05.031 10.1023/A:1015812615635 10.1002/jbm.b.33329 10.1097/00003226-199309000-00010 10.1016/j.carbpol.2013.04.022 10.1016/S0939-6411(98)00070-8 10.1097/ICO.0b013e31829cfd44 10.1046/j.1440-1681.2000.03288.x 10.1016/S0939-6411(02)00036-X 10.1007/s00417-005-0028-1 10.1517/17425247.2013.796360 10.1038/sj.eye.6700169 10.1016/S0144-8617(02)00298-9 10.1155/2014/292139 10.1097/ICO.0b013e318269cb99 10.5772/24430 10.1136/bjo.86.8.879 10.1016/j.survophthal.2003.12.009 10.1016/S0378-5173(00)00539-1 10.1080/03639040802713460 10.1089/jop.2014.0164 10.1007/BF00920939 10.1038/eye.1990.83 10.1016/j.polymdegradstab.2010.12.025 10.1016/j.addr.2005.07.005 10.1023/A:1015813225804 10.1080/10717540590952555 10.1097/OPX.0000000000000100 |
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Keywords | Viscosity Hyaluronan Corneal epithelial cells Eye drops Mucoadhesiveness |
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References | Zheng, Goto, Shiraishi, Ohashi (bib0180) 2013; 32 Liu, Harmon, Maziarz, Rah, Merchea (bib0105) 2014; 91 Van Santvliet, Ludwig (bib0170) 2004; 49 Uccello-Barretta, Nazzi, Zambito, Di Colo, Balzano, Sansò (bib0165) 2010; 395 Hill-Bator, Misiuk-Hojlo, Marycz, Grzesiak (bib0065) 2014; Vol. 2014 Harding, Rowe, Horton (bib0055) 1992 Davies (bib0040) 2000; 27 La Gatta, Papa, Schiraldi, De Rosa (bib0095) 2016; 104 Davies, Farr, Hadgraft, Kellaway (bib0035) 1991; 8 Nakamura, Hikida, Nakano, Ito, Hamano, Kinoshita (bib0130) 1993; 12 La Gatta, De Rosa, Marzaioli, Busico, Schiraldi (bib0080) 2010; 404 Liao, Jones, Forbes, Martin, Brown (bib0100) 2005; 12 Bernatchez, Tabatabay, Gurny (bib0015) 1993; 231 Di Colo, Zambito, Zaino, Sansò (bib0045) 2009; 35 McDonald, Kaye, Figueiredo, Macintosh, Lockett (bib0120) 2002; 16 Oechsner, Keipert (bib0135) 1999; 47 Zambito, Y., & Di Colo, G. (2011). Polysaccharides as Excipients for Ocular Topical Formulations La Gatta, Schiraldi, Papa, De Rosa (bib0085) 2011; 96 McKenzie, Kay (bib0125) 2015; 10 Snibson, Greaves, Soper, Prydal, Wilson, Bron (bib0155) 1990; 4 D’Agostino, A., Stellavato, A., Corsuto, L., Diana, P., Filosa, R., La Gatta, A., De Rosa, M., & Schiraldi, C., unpublished. Matsuo (bib0115) 2001; 85 Pires, Cunha, Maciel, Angelim, Melo, De Paula (bib0140) 2013; 91 Ludwig (bib0110) 2005; 57 Séchoy, Tissié, Sébastian, Maurin, Driot, Trinquand (bib0150) 2000; 207 La Gatta, Schiraldi, Papa, D’Agostino, Cammarota, De Rosa (bib0090) 2013; 96 . Ceulemans, Ludwig (bib0020) 2002; 54 Cowman, Matsuoka (bib0025) 2005; 340 Johnson, Murphy, Boulton (bib0075) 2006; 244 Tong, Petznik, Yee, Tan (bib0160) 2012; 31 Aragona, Di Stefano, Ferreri, Spinella, Stilo (bib0010) 2002; 86 Guillaumie, Furrer, Felt-Baeyens, Fuhlendorff, Nymand, Westh (bib0050) 2010; 92A Ref Almeida, Amaral, Lobão, Lobo (bib0005) 2013; 10 Hassan, Gallo (bib0060) 1990; 7 Hokputsa, Jumel, Alexander, Harding (bib0070) 2003; 52 Rangarajan, Kraybill, Ogundele, Ketelson (bib0145) 2015; 31 29253953 - Carbohydr Polym. 2018 Feb 1;181:1235-1236 Hassan (10.1016/j.carbpol.2016.07.106_bib0060) 1990; 7 Hokputsa (10.1016/j.carbpol.2016.07.106_bib0070) 2003; 52 Ref Almeida (10.1016/j.carbpol.2016.07.106_bib0005) 2013; 10 10.1016/j.carbpol.2016.07.106_bib0175 Van Santvliet (10.1016/j.carbpol.2016.07.106_bib0170) 2004; 49 10.1016/j.carbpol.2016.07.106_bib0030 Davies (10.1016/j.carbpol.2016.07.106_bib0040) 2000; 27 La Gatta (10.1016/j.carbpol.2016.07.106_bib0080) 2010; 404 La Gatta (10.1016/j.carbpol.2016.07.106_bib0095) 2016; 104 McKenzie (10.1016/j.carbpol.2016.07.106_bib0125) 2015; 10 La Gatta (10.1016/j.carbpol.2016.07.106_bib0085) 2011; 96 Rangarajan (10.1016/j.carbpol.2016.07.106_bib0145) 2015; 31 La Gatta (10.1016/j.carbpol.2016.07.106_bib0090) 2013; 96 Pires (10.1016/j.carbpol.2016.07.106_bib0140) 2013; 91 Davies (10.1016/j.carbpol.2016.07.106_bib0035) 1991; 8 Liao (10.1016/j.carbpol.2016.07.106_bib0100) 2005; 12 Matsuo (10.1016/j.carbpol.2016.07.106_bib0115) 2001; 85 Oechsner (10.1016/j.carbpol.2016.07.106_bib0135) 1999; 47 Di Colo (10.1016/j.carbpol.2016.07.106_bib0045) 2009; 35 Ceulemans (10.1016/j.carbpol.2016.07.106_bib0020) 2002; 54 Cowman (10.1016/j.carbpol.2016.07.106_bib0025) 2005; 340 Liu (10.1016/j.carbpol.2016.07.106_bib0105) 2014; 91 Aragona (10.1016/j.carbpol.2016.07.106_bib0010) 2002; 86 Hill-Bator (10.1016/j.carbpol.2016.07.106_bib0065) 2014; Vol. 2014 McDonald (10.1016/j.carbpol.2016.07.106_bib0120) 2002; 16 Tong (10.1016/j.carbpol.2016.07.106_bib0160) 2012; 31 Zheng (10.1016/j.carbpol.2016.07.106_bib0180) 2013; 32 Bernatchez (10.1016/j.carbpol.2016.07.106_bib0015) 1993; 231 Séchoy (10.1016/j.carbpol.2016.07.106_bib0150) 2000; 207 Guillaumie (10.1016/j.carbpol.2016.07.106_bib0050) 2010; 92A Johnson (10.1016/j.carbpol.2016.07.106_bib0075) 2006; 244 Ludwig (10.1016/j.carbpol.2016.07.106_bib0110) 2005; 57 Snibson (10.1016/j.carbpol.2016.07.106_bib0155) 1990; 4 Harding (10.1016/j.carbpol.2016.07.106_bib0055) 1992 Uccello-Barretta (10.1016/j.carbpol.2016.07.106_bib0165) 2010; 395 Nakamura (10.1016/j.carbpol.2016.07.106_bib0130) 1993; 12 |
References_xml | – volume: 340 start-page: 791 year: 2005 end-page: 809 ident: bib0025 article-title: Experimental approaches to hyaluronan structure publication-title: Carbohydrate Research contributor: fullname: Matsuoka – volume: 104 start-page: 9 year: 2016 end-page: 18 ident: bib0095 article-title: Hyaluronan dermal fillers via crosslinking with 1,4-butandiol diglycidyl ether: Exploitation of heterogeneous reaction conditions publication-title: Journal of Biomedical Materials Research Part B: Applied Biomaterials contributor: fullname: De Rosa – volume: 12 start-page: 327 year: 2005 end-page: 342 ident: bib0100 article-title: Hyaluronan: Pharmaceutical characterization and drug delivery publication-title: Drug Delivery contributor: fullname: Brown – volume: 4 start-page: 594 year: 1990 end-page: 602 ident: bib0155 article-title: Precorneal residence times of sodium hyaluronate solutions studied by quantitative gamma scintigraphy publication-title: Eye contributor: fullname: Bron – volume: 85 start-page: 610 year: 2001 end-page: 612 ident: bib0115 article-title: Trehalose protects corneal epithelial cells from death by drying publication-title: British Journal of Ophthalmology contributor: fullname: Matsuo – volume: 207 start-page: 109 year: 2000 end-page: 116 ident: bib0150 article-title: A new long acting ophthalmic formulation of Carteolol containing alginic acid publication-title: International Journal of Pharmaceutics contributor: fullname: Trinquand – volume: 16 start-page: 601 year: 2002 end-page: 607 ident: bib0120 article-title: A randomized, crossover, multicentre study to compare the performance of 0. 1% (w/v) sodium hyaluronate with 1.4% (w/v) polyvinyl alcohol in the alleviation of symptoms associated with dry eye syndrome publication-title: Eye contributor: fullname: Lockett – volume: 31 start-page: 491 year: 2015 end-page: 497 ident: bib0145 article-title: Effects of a hyaluronic scid/hydroxypropyl guar artificial tear solution on protection, recovery, and lubricity in models of corneal epithelium publication-title: Journal of Ocular Pharmacology and Therapeutics contributor: fullname: Ketelson – volume: 12 start-page: 433 year: 1993 end-page: 436 ident: bib0130 article-title: Characterization of water retentive properties of hyaluronan publication-title: Cornea contributor: fullname: Kinoshita – volume: 54 start-page: 41 year: 2002 end-page: 50 ident: bib0020 article-title: Optimisation of carbomer viscous eye drops: An in vitro experimental design approach using rheological techniques publication-title: European Journal of Pharmaceutics and Biopharmaceutics contributor: fullname: Ludwig – volume: 92A start-page: 1421 year: 2010 end-page: 1430 ident: bib0050 article-title: Comparative studies of various hyaluronic acids produced by microbial fermentation for potential topical ophthalmic applications publication-title: Journal of Biomedical Materials Research contributor: fullname: Westh – volume: 244 start-page: 109 year: 2006 end-page: 112 ident: bib0075 article-title: Effectiveness of sodium hyaluronate eyedrops in the treatment of dry eye publication-title: Graefe's Archive for Clinical and Experimental Ophthalmology contributor: fullname: Boulton – volume: 49 start-page: 197 year: 2004 end-page: 213 ident: bib0170 article-title: Determinants of eye drop size publication-title: Survey of Ophthalmology contributor: fullname: Ludwig – volume: 96 start-page: 536 year: 2013 end-page: 544 ident: bib0090 article-title: Hyaluronan scaffolds via diglycidyl ether crosslinking: Toward improvements in composition and performance publication-title: Carbohydrate Polymers contributor: fullname: De Rosa – volume: 52 start-page: 111 year: 2003 end-page: 117 ident: bib0070 article-title: Hydrodynamic characterization of chemically degraded hyaluronic acid publication-title: Carbohydrate Polymers contributor: fullname: Harding – volume: 395 start-page: 122 year: 2010 end-page: 131 ident: bib0165 article-title: Synergistic interaction between TS-polysaccharide and hyaluronic acid: Implications in the formulation of eye drops publication-title: International Journal of Pharmaceutics contributor: fullname: Sansò – volume: 91 start-page: 32 year: 2014 end-page: 38 ident: bib0105 article-title: Comparative studies of hyaluronan in marketed ophthalmic products publication-title: Optometry and Vision Science contributor: fullname: Merchea – volume: 86 start-page: 879 year: 2002 end-page: 884 ident: bib0010 article-title: Sodium hyaluronate eye drops of different osmolarity for the treatment of dry eye in Sjögren’s syndrome patients publication-title: British Journal of Ophthalmology contributor: fullname: Stilo – volume: 7 start-page: 491 year: 1990 end-page: 495 ident: bib0060 article-title: A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength publication-title: Pharmaceutical Research contributor: fullname: Gallo – volume: 91 start-page: 92 year: 2013 end-page: 99 ident: bib0140 article-title: Sulfated chitosan as tear substitute with no antimicrobial activity publication-title: Carbohydrate Polymers contributor: fullname: De Paula – volume: 31 start-page: S32 year: 2012 end-page: S36 ident: bib0160 article-title: Choice of artificial tear formulation for patients with dry eye: Where do we start? publication-title: Cornea contributor: fullname: Tan – volume: 10 start-page: 127 year: 2015 end-page: 133 ident: bib0125 article-title: Eye gels for ophthalmic delivery publication-title: Expert Review of Ophthalmology contributor: fullname: Kay – volume: 32 start-page: 1260 year: 2013 end-page: 1264 ident: bib0180 article-title: In vitro efficacy of ocular surface lubricants against dehydration publication-title: Cornea contributor: fullname: Ohashi – volume: 96 start-page: 630 year: 2011 end-page: 636 ident: bib0085 article-title: Comparative analysis of commercial dermal fillers based on crosslinked hyaluronan: Physical characterization and in vitro enzymatic degradation publication-title: Polymer Degradation and Stability contributor: fullname: De Rosa – volume: Vol. 2014 year: 2014 ident: bib0065 article-title: Trehalose-Based eye drops preserve viability and functionality of cultured human corneal epithelial cells during desiccation publication-title: BioMed Research International contributor: fullname: Grzesiak – start-page: 495 year: 1992 end-page: 513 ident: bib0055 article-title: Sedimentation analysis of polysaccharides publication-title: Analytical ultracentrifugation in biochemistry and polymer science contributor: fullname: Horton – volume: 35 start-page: 941 year: 2009 end-page: 949 ident: bib0045 article-title: Selected polysaccharides at comparison for their mucoadhesiveness and effect on precorneal residence of different drugs in the rabbit model publication-title: Drug Development and Industrial Pharmacy contributor: fullname: Sansò – volume: 57 start-page: 1595 year: 2005 end-page: 1639 ident: bib0110 article-title: The use of mucoadhesive polymers in ocular drug delivery publication-title: Advanced Drug Delivery Reviews contributor: fullname: Ludwig – volume: 47 start-page: 113 year: 1999 end-page: 118 ident: bib0135 article-title: Polyacrylic acid/polyvinylpyrrolidone biopolymeric systems. I. Rheological and mucoadhesive properties of formulations potentially useful for the treatment of dry-eye-syndrome publication-title: European Journal of Pharmaceutics and Biopharmaceutics contributor: fullname: Keipert – volume: 10 start-page: 1223 year: 2013 end-page: 1237 ident: bib0005 article-title: Applications of poloxamers in ophthalmic pharmaceutical formulations: An overview publication-title: Expert Opinion on Drug Delivery contributor: fullname: Lobo – volume: 8 start-page: 1039 year: 1991 end-page: 1043 ident: bib0035 article-title: Evaluation of mucoadhesive polymers in ocular drug delivery. I. Viscous solutions publication-title: Pharmaceutical Research contributor: fullname: Kellaway – volume: 404 start-page: 21 year: 2010 end-page: 29 ident: bib0080 article-title: A complete hyaluronan hydrodynamic characterization using a triple detector-SEC system during in vitro enzymatic degradation publication-title: Analytical Biochemistry contributor: fullname: Schiraldi – volume: 231 start-page: 157 year: 1993 end-page: 161 ident: bib0015 article-title: Sodium hyaluronate 0.25% used as a vehicle increases the bioavailability of topically administered gentamicin publication-title: Graefe's Archive for Clinical and Experimental Ophthalmology contributor: fullname: Gurny – volume: 27 start-page: 558 year: 2000 end-page: 562 ident: bib0040 article-title: Biopharmaceutical considerations in topical ocular drug delivery publication-title: Clinical and Experimental Pharmacology and Physiology contributor: fullname: Davies – volume: 85 start-page: 610 year: 2001 ident: 10.1016/j.carbpol.2016.07.106_bib0115 article-title: Trehalose protects corneal epithelial cells from death by drying publication-title: British Journal of Ophthalmology doi: 10.1136/bjo.85.5.610 contributor: fullname: Matsuo – volume: 340 start-page: 791 year: 2005 ident: 10.1016/j.carbpol.2016.07.106_bib0025 article-title: Experimental approaches to hyaluronan structure publication-title: Carbohydrate Research doi: 10.1016/j.carres.2005.01.022 contributor: fullname: Cowman – volume: 91 start-page: 92 year: 2013 ident: 10.1016/j.carbpol.2016.07.106_bib0140 article-title: Sulfated chitosan as tear substitute with no antimicrobial activity publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2012.08.011 contributor: fullname: Pires – volume: 10 start-page: 127 year: 2015 ident: 10.1016/j.carbpol.2016.07.106_bib0125 article-title: Eye gels for ophthalmic delivery publication-title: Expert Review of Ophthalmology doi: 10.1586/17469899.2015.1015993 contributor: fullname: McKenzie – volume: 404 start-page: 21 year: 2010 ident: 10.1016/j.carbpol.2016.07.106_bib0080 article-title: A complete hyaluronan hydrodynamic characterization using a triple detector-SEC system during in vitro enzymatic degradation publication-title: Analytical Biochemistry doi: 10.1016/j.ab.2010.04.014 contributor: fullname: La Gatta – volume: 395 start-page: 122 year: 2010 ident: 10.1016/j.carbpol.2016.07.106_bib0165 article-title: Synergistic interaction between TS-polysaccharide and hyaluronic acid: Implications in the formulation of eye drops publication-title: International Journal of Pharmaceutics doi: 10.1016/j.ijpharm.2010.05.031 contributor: fullname: Uccello-Barretta – volume: 7 start-page: 491 year: 1990 ident: 10.1016/j.carbpol.2016.07.106_bib0060 article-title: A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength publication-title: Pharmaceutical Research doi: 10.1023/A:1015812615635 contributor: fullname: Hassan – volume: 104 start-page: 9 year: 2016 ident: 10.1016/j.carbpol.2016.07.106_bib0095 article-title: Hyaluronan dermal fillers via crosslinking with 1,4-butandiol diglycidyl ether: Exploitation of heterogeneous reaction conditions publication-title: Journal of Biomedical Materials Research Part B: Applied Biomaterials doi: 10.1002/jbm.b.33329 contributor: fullname: La Gatta – volume: 12 start-page: 433 year: 1993 ident: 10.1016/j.carbpol.2016.07.106_bib0130 article-title: Characterization of water retentive properties of hyaluronan publication-title: Cornea doi: 10.1097/00003226-199309000-00010 contributor: fullname: Nakamura – volume: 96 start-page: 536 year: 2013 ident: 10.1016/j.carbpol.2016.07.106_bib0090 article-title: Hyaluronan scaffolds via diglycidyl ether crosslinking: Toward improvements in composition and performance publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2013.04.022 contributor: fullname: La Gatta – volume: 47 start-page: 113 year: 1999 ident: 10.1016/j.carbpol.2016.07.106_bib0135 article-title: Polyacrylic acid/polyvinylpyrrolidone biopolymeric systems. I. Rheological and mucoadhesive properties of formulations potentially useful for the treatment of dry-eye-syndrome publication-title: European Journal of Pharmaceutics and Biopharmaceutics doi: 10.1016/S0939-6411(98)00070-8 contributor: fullname: Oechsner – volume: 32 start-page: 1260 year: 2013 ident: 10.1016/j.carbpol.2016.07.106_bib0180 article-title: In vitro efficacy of ocular surface lubricants against dehydration publication-title: Cornea doi: 10.1097/ICO.0b013e31829cfd44 contributor: fullname: Zheng – volume: 27 start-page: 558 year: 2000 ident: 10.1016/j.carbpol.2016.07.106_bib0040 article-title: Biopharmaceutical considerations in topical ocular drug delivery publication-title: Clinical and Experimental Pharmacology and Physiology doi: 10.1046/j.1440-1681.2000.03288.x contributor: fullname: Davies – volume: 54 start-page: 41 year: 2002 ident: 10.1016/j.carbpol.2016.07.106_bib0020 article-title: Optimisation of carbomer viscous eye drops: An in vitro experimental design approach using rheological techniques publication-title: European Journal of Pharmaceutics and Biopharmaceutics doi: 10.1016/S0939-6411(02)00036-X contributor: fullname: Ceulemans – volume: 244 start-page: 109 year: 2006 ident: 10.1016/j.carbpol.2016.07.106_bib0075 article-title: Effectiveness of sodium hyaluronate eyedrops in the treatment of dry eye publication-title: Graefe's Archive for Clinical and Experimental Ophthalmology doi: 10.1007/s00417-005-0028-1 contributor: fullname: Johnson – volume: 10 start-page: 1223 year: 2013 ident: 10.1016/j.carbpol.2016.07.106_bib0005 article-title: Applications of poloxamers in ophthalmic pharmaceutical formulations: An overview publication-title: Expert Opinion on Drug Delivery doi: 10.1517/17425247.2013.796360 contributor: fullname: Ref Almeida – volume: 16 start-page: 601 year: 2002 ident: 10.1016/j.carbpol.2016.07.106_bib0120 article-title: A randomized, crossover, multicentre study to compare the performance of 0. 1% (w/v) sodium hyaluronate with 1.4% (w/v) polyvinyl alcohol in the alleviation of symptoms associated with dry eye syndrome publication-title: Eye doi: 10.1038/sj.eye.6700169 contributor: fullname: McDonald – volume: 52 start-page: 111 year: 2003 ident: 10.1016/j.carbpol.2016.07.106_bib0070 article-title: Hydrodynamic characterization of chemically degraded hyaluronic acid publication-title: Carbohydrate Polymers doi: 10.1016/S0144-8617(02)00298-9 contributor: fullname: Hokputsa – volume: Vol. 2014 year: 2014 ident: 10.1016/j.carbpol.2016.07.106_bib0065 article-title: Trehalose-Based eye drops preserve viability and functionality of cultured human corneal epithelial cells during desiccation publication-title: BioMed Research International doi: 10.1155/2014/292139 contributor: fullname: Hill-Bator – volume: 31 start-page: S32 year: 2012 ident: 10.1016/j.carbpol.2016.07.106_bib0160 article-title: Choice of artificial tear formulation for patients with dry eye: Where do we start? publication-title: Cornea doi: 10.1097/ICO.0b013e318269cb99 contributor: fullname: Tong – ident: 10.1016/j.carbpol.2016.07.106_bib0175 doi: 10.5772/24430 – volume: 86 start-page: 879 year: 2002 ident: 10.1016/j.carbpol.2016.07.106_bib0010 article-title: Sodium hyaluronate eye drops of different osmolarity for the treatment of dry eye in Sjögren’s syndrome patients publication-title: British Journal of Ophthalmology doi: 10.1136/bjo.86.8.879 contributor: fullname: Aragona – volume: 49 start-page: 197 year: 2004 ident: 10.1016/j.carbpol.2016.07.106_bib0170 article-title: Determinants of eye drop size publication-title: Survey of Ophthalmology doi: 10.1016/j.survophthal.2003.12.009 contributor: fullname: Van Santvliet – volume: 207 start-page: 109 year: 2000 ident: 10.1016/j.carbpol.2016.07.106_bib0150 article-title: A new long acting ophthalmic formulation of Carteolol containing alginic acid publication-title: International Journal of Pharmaceutics doi: 10.1016/S0378-5173(00)00539-1 contributor: fullname: Séchoy – volume: 35 start-page: 941 year: 2009 ident: 10.1016/j.carbpol.2016.07.106_bib0045 article-title: Selected polysaccharides at comparison for their mucoadhesiveness and effect on precorneal residence of different drugs in the rabbit model publication-title: Drug Development and Industrial Pharmacy doi: 10.1080/03639040802713460 contributor: fullname: Di Colo – volume: 92A start-page: 1421 year: 2010 ident: 10.1016/j.carbpol.2016.07.106_bib0050 article-title: Comparative studies of various hyaluronic acids produced by microbial fermentation for potential topical ophthalmic applications publication-title: Journal of Biomedical Materials Research contributor: fullname: Guillaumie – volume: 31 start-page: 491 year: 2015 ident: 10.1016/j.carbpol.2016.07.106_bib0145 article-title: Effects of a hyaluronic scid/hydroxypropyl guar artificial tear solution on protection, recovery, and lubricity in models of corneal epithelium publication-title: Journal of Ocular Pharmacology and Therapeutics doi: 10.1089/jop.2014.0164 contributor: fullname: Rangarajan – volume: 231 start-page: 157 year: 1993 ident: 10.1016/j.carbpol.2016.07.106_bib0015 article-title: Sodium hyaluronate 0.25% used as a vehicle increases the bioavailability of topically administered gentamicin publication-title: Graefe's Archive for Clinical and Experimental Ophthalmology doi: 10.1007/BF00920939 contributor: fullname: Bernatchez – volume: 4 start-page: 594 year: 1990 ident: 10.1016/j.carbpol.2016.07.106_bib0155 article-title: Precorneal residence times of sodium hyaluronate solutions studied by quantitative gamma scintigraphy publication-title: Eye doi: 10.1038/eye.1990.83 contributor: fullname: Snibson – volume: 96 start-page: 630 year: 2011 ident: 10.1016/j.carbpol.2016.07.106_bib0085 article-title: Comparative analysis of commercial dermal fillers based on crosslinked hyaluronan: Physical characterization and in vitro enzymatic degradation publication-title: Polymer Degradation and Stability doi: 10.1016/j.polymdegradstab.2010.12.025 contributor: fullname: La Gatta – volume: 57 start-page: 1595 year: 2005 ident: 10.1016/j.carbpol.2016.07.106_bib0110 article-title: The use of mucoadhesive polymers in ocular drug delivery publication-title: Advanced Drug Delivery Reviews doi: 10.1016/j.addr.2005.07.005 contributor: fullname: Ludwig – start-page: 495 year: 1992 ident: 10.1016/j.carbpol.2016.07.106_bib0055 article-title: Sedimentation analysis of polysaccharides contributor: fullname: Harding – volume: 8 start-page: 1039 year: 1991 ident: 10.1016/j.carbpol.2016.07.106_bib0035 article-title: Evaluation of mucoadhesive polymers in ocular drug delivery. I. Viscous solutions publication-title: Pharmaceutical Research doi: 10.1023/A:1015813225804 contributor: fullname: Davies – volume: 12 start-page: 327 year: 2005 ident: 10.1016/j.carbpol.2016.07.106_bib0100 article-title: Hyaluronan: Pharmaceutical characterization and drug delivery publication-title: Drug Delivery doi: 10.1080/10717540590952555 contributor: fullname: Liao – ident: 10.1016/j.carbpol.2016.07.106_bib0030 – volume: 91 start-page: 32 year: 2014 ident: 10.1016/j.carbpol.2016.07.106_bib0105 article-title: Comparative studies of hyaluronan in marketed ophthalmic products publication-title: Optometry and Vision Science doi: 10.1097/OPX.0000000000000100 contributor: fullname: Liu |
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Snippet | •Hydrodynamic and rheological evaluations of HA-based eye drops were achieved.•Most of commercial HA-based eye drops are not optimized.•Combinations of HA... Hyaluronan (HA) is frequently incorporated in eye drops to extend the pre-corneal residence time, due to its viscosifying and mucoadhesive properties.... |
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SubjectTerms | Corneal epithelial cells Eye drops Hyaluronan Mucoadhesiveness Viscosity |
Title | Optimization of hyaluronan-based eye drop formulations |
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