epithelial-mesenchymal transition: new insights in signaling, development, and disease

• Published in: The Journal of cell biology Vol. 172; no. 7; pp. 973 - 981
• Main Authors: Lee, Jonathan M, Dedhar, Shoukat, Kalluri, Raghu, Thompson, Erik W
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 27.03.2006; Rockefeller University Press
• Subjects: Animals; Cadherins; Cancer; Cell Differentiation - physiology; Cell lines; Cellular biology; Embryonic growth stage; Epithelial cells; Epithelial Cells - cytology; Epithelial Cells - physiology; Epithelium - embryology; Female; Fibrosis; Genes; Humans; Mesenchymal stem cells; Mesoderm - cytology; Mesoderm - physiology; Mini-Reviews; Neoplasm Invasiveness - pathology; Neoplasm Invasiveness - physiopathology; Neoplasms - pathology; Neoplasms - physiopathology; Phosphorylation; Proteins; Reviews; Signal Transduction - physiology; Transcription factors; Tumors

The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. Current interest in this process, which is described as an epithelial-mesenchymal transition (EMT), stems from its developmental importance and its...