Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases

• Published in: The Journal of cell biology Vol. 167; no. 6; pp. 1195 - 1204
• Main Authors: Kong, Xiang-Tian, Deng, Fang-Ming, Hu, Ping, Liang, Feng-Xia, Zhou, Ge, Auerbach, Anna B, Genieser, Nancy, Nelson, Peter K, Robbins, Edith S, Shapiro, Ellen, Kachar, Bechara, Sun, Tung-Tien
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 20.12.2004; The Rockefeller University Press
• Subjects: Animals; B lymphocytes; Cell lines; Cellular biology; Epithelium; Genetic Predisposition to Disease; Genetics; Hydronephrosis; Kidney Diseases - genetics; Kidney Diseases - pathology; Membrane Glycoproteins - genetics; Membrane Glycoproteins - physiology; Membrane Proteins - genetics; Membrane Proteins - physiology; Mice; Mice, Knockout; Phenotype; Umbrellas; Ureter; Urinary bladder; Urination; Urologic Diseases - genetics; Urologic Diseases - metabolism; Urologic Diseases - pathology; Uroplakin II; Uroplakin III; Urothelium; Urothelium - cytology; Urothelium - pathology; Urothelium - physiology; Vesico-Ureteral Reflux - metabolism; Water pressure

The apical surface of mouse urothelium is covered by two-dimensional crystals (plaques) of uroplakin (UP) particles. To study uroplakin function, we ablated the mouse UPII gene. A comparison of the phenotypes of UPII- and UPIII-deficient mice yielded new insights into the mechanism of plaque formati...