Effect of Contact Lens on Optical Coherence Tomography Imaging of Rodent Retina
ABSTRACT Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. Methods: A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolutio...
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Published in | Current eye research Vol. 38; no. 12; pp. 1235 - 1240 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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England
Informa Healthcare USA, Inc
01.12.2013
Taylor & Francis |
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Abstract | ABSTRACT
Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina.
Methods: A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality.
Results: The fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens.
Conclusions: We have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens. |
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AbstractList | To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina.PURPOSETo evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina.A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality.METHODSA spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality.The fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens.RESULTSThe fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens.We have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens.CONCLUSIONSWe have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens. ABSTRACT Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. Methods: A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality. Results: The fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens. Conclusions: We have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens. To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality. The fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens. We have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens. Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. Methods: A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality. Results: The fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens. Conclusions: We have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens. |
Author | Camesa, Adam Jiao, Shuliang Liu, Xiaojing Wang, Chia-Hao Zhang, Hao F. Dai, Cuixia |
AuthorAffiliation | 4 Department of Orthopedics, University of California, Santa Barbara, Santa Barbara, CA, USA 1 Department of Biomedical Engineering, Florida International University, Miami, FL, USA 2 Department of Ophthalmology, University of Southern California, Los Angeles, CA, USA 5 Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA 3 College of Science, Shanghai Institute of Technology, Shanghai, China |
AuthorAffiliation_xml | – name: 1 Department of Biomedical Engineering, Florida International University, Miami, FL, USA – name: 2 Department of Ophthalmology, University of Southern California, Los Angeles, CA, USA – name: 5 Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA – name: 4 Department of Orthopedics, University of California, Santa Barbara, Santa Barbara, CA, USA – name: 3 College of Science, Shanghai Institute of Technology, Shanghai, China |
Author_xml | – sequence: 1 givenname: Xiaojing surname: Liu fullname: Liu, Xiaojing email: shjiao@fiu.edu, shjiao@fiu.edu organization: Department of Biomedical Engineering, Florida International University – sequence: 2 givenname: Chia-Hao surname: Wang fullname: Wang, Chia-Hao email: shjiao@fiu.edu, shjiao@fiu.edu organization: Department of Ophthalmology, University of Southern California, Los Angeles – sequence: 3 givenname: Cuixia surname: Dai fullname: Dai, Cuixia email: shjiao@fiu.edu, shjiao@fiu.edu organization: College of Science, Shanghai Institute of Technology – sequence: 4 givenname: Adam surname: Camesa fullname: Camesa, Adam email: shjiao@fiu.edu, shjiao@fiu.edu organization: Department of Orthopedics, University of California, Santa Barbara, Santa Barbara – sequence: 5 givenname: Hao F. surname: Zhang fullname: Zhang, Hao F. email: shjiao@fiu.edu, shjiao@fiu.edu organization: Department of Biomedical Engineering, Northwestern University, Evanston – sequence: 6 givenname: Shuliang surname: Jiao fullname: Jiao, Shuliang email: shjiao@fiu.edu, shjiao@fiu.edu organization: Department of Biomedical Engineering, Florida International University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24000814$$D View this record in MEDLINE/PubMed |
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Copyright | 2013 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted 2013 2013 Informa Healthcare USA, Inc. 2013 |
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Snippet | ABSTRACT
Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina.
Methods:... Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. Methods: A... To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. A spectral-domain optical... To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina.PURPOSETo evaluate the... |
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SubjectTerms | Animals Contact lens Contact Lenses Corneal Wavefront Aberration - prevention & control Equipment Design optical coherence tomography Rats Rats, Sprague-Dawley resolution improvement Retina - anatomy & histology retinal imaging Retinal Vessels - anatomy & histology Signal-To-Noise Ratio Tomography, Optical Coherence - instrumentation Tomography, Optical Coherence - methods |
Title | Effect of Contact Lens on Optical Coherence Tomography Imaging of Rodent Retina |
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