Effect of Contact Lens on Optical Coherence Tomography Imaging of Rodent Retina

ABSTRACT Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. Methods: A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolutio...

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Published inCurrent eye research Vol. 38; no. 12; pp. 1235 - 1240
Main Authors Liu, Xiaojing, Wang, Chia-Hao, Dai, Cuixia, Camesa, Adam, Zhang, Hao F., Jiao, Shuliang
Format Journal Article
LanguageEnglish
Published England Informa Healthcare USA, Inc 01.12.2013
Taylor & Francis
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Abstract ABSTRACT Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. Methods: A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality. Results: The fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens. Conclusions: We have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens.
AbstractList To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina.PURPOSETo evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina.A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality.METHODSA spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality.The fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens.RESULTSThe fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens.We have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens.CONCLUSIONSWe have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens.
ABSTRACT Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. Methods: A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality. Results: The fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens. Conclusions: We have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens.
To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality. The fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens. We have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens.
Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. Methods: A spectral-domain optical coherence tomography (SD-OCT) system was built for in vivo imaging of rodent retina. The calibrated depth resolution of the system was 3 µm in tissue. A commercial powerless contact lens for rat eye was tested in the experiments. For each rat eye, the retina was imaged in vivo sequentially first without wearing contact lens and then with wearing contact lens. The lateral resolution and signal-to-noise ratio of the OCT images with and without contact lens were compared to evaluate the improvement of image quality. Results: The fundus images generated from the measured 3D OCT datasets with contact lens showed sharper retinal blood vessels than those without contact lens. The contrast of the retinal blood vessels was also significantly enhanced in the OCT fundus images with contact lens. As high as 10 dB improvements in SNR was observed for OCT images with contact lens compared to the images of the same retinal area without contact lens. Conclusions: We have demonstrated that the use of powerless contact lens on rat eye can significantly improve OCT image quality of rodent retina, which is a benefit in addition to preventing cataract formation. We believe the improvement in image quality is the result of partial compensation of the optical aberrations of the rodent eye by the contact lens.
Author Camesa, Adam
Jiao, Shuliang
Liu, Xiaojing
Wang, Chia-Hao
Zhang, Hao F.
Dai, Cuixia
AuthorAffiliation 4 Department of Orthopedics, University of California, Santa Barbara, Santa Barbara, CA, USA
1 Department of Biomedical Engineering, Florida International University, Miami, FL, USA
2 Department of Ophthalmology, University of Southern California, Los Angeles, CA, USA
5 Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
3 College of Science, Shanghai Institute of Technology, Shanghai, China
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/24000814$$D View this record in MEDLINE/PubMed
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Snippet ABSTRACT Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. Methods:...
Purpose: To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. Methods: A...
To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina. A spectral-domain optical...
To evaluate the effect of powerless contact lens on improving the quality of optical coherence tomography imaging of rodent retina.PURPOSETo evaluate the...
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StartPage 1235
SubjectTerms Animals
Contact lens
Contact Lenses
Corneal Wavefront Aberration - prevention & control
Equipment Design
optical coherence tomography
Rats
Rats, Sprague-Dawley
resolution improvement
Retina - anatomy & histology
retinal imaging
Retinal Vessels - anatomy & histology
Signal-To-Noise Ratio
Tomography, Optical Coherence - instrumentation
Tomography, Optical Coherence - methods
Title Effect of Contact Lens on Optical Coherence Tomography Imaging of Rodent Retina
URI https://www.tandfonline.com/doi/abs/10.3109/02713683.2013.815218
https://www.ncbi.nlm.nih.gov/pubmed/24000814
https://www.proquest.com/docview/1443422592
https://pubmed.ncbi.nlm.nih.gov/PMC4291550
Volume 38
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