Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism - Huang, Chia-Ying; Shih, Hao-Wei; Lin, Li-Ying; Tien, Yi-Wen; Cheng, Ting-Jen Rachel; Cheng, Wei-Chieh; Wong, Chi-Huey; Ma, Che (Proceedings of the National Academy of Sciences - PNAS, 2012)
Keywords: Amino Acid Sequence; Antibiotic resistance; Antibiotics; bacteria; Bacterial diseases; Biological Sciences; biosynthesis; Cell walls; chemistry; Crystal structure; Crystallography, X-Ray; Diphosphates; Drug development; Drug resistance; Electron density; Enzymatic activity; enzyme activity; Enzymes; enzymology; Glycosyltransferase; Glycosyltransferases; Glycosyltransferases - chemistry; Infection; Lipids; Lipids - chemistry; Models, Molecular; moenomycin; Molecular Sequence Data; Molecular structure; Mutagenesis; Peptidoglycan; Peptidoglycan - biosynthesis; peptidoglycans; Phosphates; Physical Sciences; Polysaccharides; Protein Conformation; Sequence alignment; Sequence Homology, Amino Acid; Staphylococcus aureus; Staphylococcus aureus - enzymology; Staphylococcus infections