Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel

• Published in: Scientific reports Vol. 14; no. 1; pp. 28774 - 14
• Main Authors: Okamura, Yui, Gochi, Kei, Ishikawa, Tatsuya, Hayashi, Takuto, Fuseya, Sayaka, Suzuki, Riku, Kanai, Maho, Inoue, Yuri, Murakami, Yuka, Sadaki, Shunya, Jeon, Hyojung, Hayama, Mio, Ishii, Hiroto, Tsunakawa, Yuki, Ochi, Hiroki, Sato, Shingo, Hamada, Michito, Abe, Chikara, Morita, Hironobu, Okada, Risa, Shiba, Dai, Muratani, Masafumi, Shinohara, Masahiro, Akiyama, Taishin, Kudo, Takashi, Takahashi, Satoru
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.11.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250; 631/337/2019; 631/443/63; Animals; Atrophy; Bone; Bone and Bones - metabolism; Bone Density; Gene expression; Humanities and Social Sciences; Immune System; Male; Mice; Mice, Inbred C57BL; Microgravity; Moon; multidisciplinary; Science; Science (multidisciplinary); Space Flight; Spaceflight; Spleen; Spleen - immunology; Spleen - metabolism; Thymus; Thymus gland; Thymus Gland - immunology; Thymus Gland - metabolism; Weightlessness - adverse effects; Spleen; Bone; Gene expression; Microgravity; Spaceflight; Thymus

Long-duration spaceflight creates a variety of stresses due to the unique environment, which can lead to compromised functioning of the skeletal and immune systems. However, the mechanisms by which organisms respond to this stress remain unclear. The present study aimed to investigate the impact of...