Peroxiredoxin 2: An Important Element of the Antioxidant Defense of the Erythrocyte

• Published in: Antioxidants Vol. 12; no. 5; p. 1012
• Main Authors: Sadowska-Bartosz, Izabela, Bartosz, Grzegorz
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.04.2023; MDPI
• Subjects: Acetylation; Amino acids; antioxidant; antioxidant activity; Antioxidants; autoxidation; B cells; Calcium; calpromotin; Chemical bonds; Circadian rhythms; cysteine; Cytosol; Enzymes; erythrocyte; erythrocyte membrane; erythrocytes; Glutathione; Hemoglobin; Hydrogen peroxide; hydroperoxides; lipids; Membrane proteins; Nitration; Oxidants; Oxidation; Oxidative stress; Peroxiredoxin; Phosphorylation; Physiology; Post-translation; Potassium; potassium channels; Potassium channels (calcium-gated); Proteins; Review; Thiols; Thioredoxin; thioredoxins; Uric acid; peroxiredoxin; antioxidant; calpromotin; thioredoxin; glutathione; hydrogen peroxide; erythrocyte

Peroxiredoxin 2 (Prdx2) is the third most abundant erythrocyte protein. It was known previously as calpromotin since its binding to the membrane stimulates the calcium-dependent potassium channel. Prdx2 is present mostly in cytosol in the form of non-covalent dimers but may associate into doughnut-l...