Decreased ratio of influenza-specific IgG versus IgM in response to influenza vaccination in antiretroviral-treated HIV-infected African Americans compared to Caucasians, and its direct correlation with the percentages of peripheral Tfh cells

• Published in: Vaccine Vol. 38; no. 8; pp. 1998 - 2004
• Main Authors: Ma, Ping, Luo, Zhenwu, Qian, Jing, Yan, Zhongfang, Zhang, Lumin, Martin, Lisa, Wang, Ziyu, Xia, Huan, Yu, Fangfang, Jiang, Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 18.02.2020; Elsevier Limited
• Subjects: Adult; African Americans; Allergy and Immunology; Antibodies, Viral - blood; Antibody responses; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; B cells; B-lymphocytes; Bacterial diseases; bacterial infections; Case-Control Studies; CD19 antigen; CD3 antigen; CD4 antigen; Control methods; Correlation; Disease; disease progression; enzyme-linked immunosorbent assay; European Continental Ancestry Group; Female; Flow cytometry; HIV; HIV disease; HIV infections; HIV Infections - drug therapy; HIV Infections - ethnology; Human immunodeficiency virus; Humans; IgG antibody; Immunization; Immunoglobulin Class Switching; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin M; Immunoglobulin M - blood; Influenza; influenza vaccination; Influenza vaccine; influenza vaccines; Influenza Vaccines - immunology; Influenza, Human - ethnology; Influenza, Human - prevention & control; Lymphocytes; Lymphocytes B; Lymphocytes T; Male; Middle Aged; Minority & ethnic groups; Population; Public health; Race; Racial differences; Statistical analysis; Substance abuse treatment; T Follicular Helper Cells - cytology; T-lymphocytes; Vaccination; Vaccines; Viral infections; Whites; Antibody responses; B cells; Influenza vaccine; HIV disease

Racial differences have been observed in the rate of bacterial infection and disease progression in HIV. Here, we evaluate racial differences in seasonal influenza vaccine responses. 16 healthy controls (9 Caucasians (CC) and 7 African Americans (AA)) and 26 antiretroviral therapy (ART)-treated avir...