Atlas-based head modeling and spatial normalization for high-density diffuse optical tomography: In vivo validation against fMRI

• Published in: NeuroImage (Orlando, Fla.) Vol. 85; no. 1; pp. 117 - 126
• Main Authors: Ferradal, Silvina L., Eggebrecht, Adam T., Hassanpour, Mahlega, Snyder, Abraham Z., Culver, Joseph P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.01.2014
• Subjects: Adult; Anatomical atlas; Atlases as Topic; Brain mapping; Brain Mapping - methods; Brain Mapping - statistics & numerical data; Diffuse optical tomography; Female; Functional magnetic resonance imaging; Group analysis; Head - anatomy & histology; Humans; Image Processing, Computer-Assisted - methods; Image Processing, Computer-Assisted - statistics & numerical data; Individuality; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - statistics & numerical data; Male; Models, Anatomic; Non-linear registration; Nonlinear Dynamics; Oxygen Consumption - physiology; Reference Values; Spatial normalization; Tomography, Optical - methods; Tomography, Optical - statistics & numerical data; Young Adult; Non-linear registration; Brain mapping; HD-DOT; FOV; Diffuse optical tomography; Spatial normalization; Functional magnetic resonance imaging; HbR; Group analysis; HbT; DOI; HbO2; Anatomical atlas; total hemoglobin; diffuse optical imaging; field of view; oxyhemoglobin; HbO; high-density diffuse optical tomography; deoxyhemoglobin

Diffuse optical imaging (DOI) is increasingly becoming a valuable neuroimaging tool when fMRI is precluded. Recent developments in high-density diffuse optical tomography (HD-DOT) overcome previous limitations of sparse DOI systems, providing improved image quality and brain specificity. These impro...