The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria

• Published in: Trends in microbiology (Regular ed.) Vol. 25; no. 6; pp. 456 - 466
• Main Authors: Van Acker, Heleen, Coenye, Tom
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2017; Elsevier Science Ltd
• Subjects: Anti-Bacterial Agents - pharmacology; antibacterial properties; Antibiotics; Antitoxins; Bacteria; Bacteria - drug effects; Bacterial Infections - drug therapy; Eukaryotic Cells - drug effects; Inactivation, Metabolic - drug effects; Internal Medicine; Metabolic Networks and Pathways - drug effects; Metabolism; Microbial Viability - drug effects; Oxidative Stress; Reactive oxygen species; Reactive Oxygen Species - metabolism; Reactive Oxygen Species - pharmacology; ROS; Toxins; Antibiotics; Metabolism; ROS

Recently, it was proposed that there is a common mechanism behind the activity of bactericidal antibiotics, involving the production of reactive oxygen species (ROS). However, the involvement of ROS in antibiotic-mediated killing has become the subject of much debate. In the present review, we provi...