Effect of treatment on serum glial cell line-derived neurotrophic factor in bipolar patients

• Published in: Journal of affective disorders Vol. 126; no. 1; pp. 326 - 329
• Main Authors: Zhang, Xiaobin, Zhang, Zhijun, Sha, Weiwei, Xie, Chunming, Xi, Guangjun, Zhou, Honghui, Zhang, Yumei
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 01.10.2010; Elsevier
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Aged; Antidepressive Agents - therapeutic use; Antipsychotic Agents - therapeutic use; Biological and medical sciences; Bipolar affective disorder; Bipolar disorder (BD); Bipolar Disorder - blood; Bipolar Disorder - drug therapy; Bipolar Disorder - physiopathology; Bipolar disorders; Case-Control Studies; Depression; Drug abuse; Enzyme-Linked Immunosorbent Assay; Female; Glial cell line-derived neurotrophic factor (GDNF); Glial Cell Line-Derived Neurotrophic Factor - blood; Glial Cell Line-Derived Neurotrophic Factor - physiology; Humans; Male; Mania; Medical sciences; Middle Aged; Mood disorders; Nervous system; Pathophysiological aspects; Psychiatric/Mental Health; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Serum; Treatment; Young Adult; Mania; Depression; Glial cell line-derived neurotrophic factor (GDNF); Bipolar disorder (BD); Mood disorder; Glial cell line-derived neurotrophic factor; Treatment; GDNF; Glial cell line derived neurotrophic factor; Bipolar disorder

Post-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor β family which has been implicated in the pathophysi...