Effect of treatment on serum glial cell line-derived neurotrophic factor in bipolar patients
Post-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor β family which has been implicated in the pathophysi...
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| Published in | Journal of affective disorders Vol. 126; no. 1; pp. 326 - 329 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Elsevier B.V
01.10.2010
Elsevier |
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| Online Access | Get full text |
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| Abstract | Post-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor β family which has been implicated in the pathophysiology of BD. This study aimed to determine whether GDNF in serum was abnormal in BD, and how it responded to drug treatment of BD.
Serum GDNF concentrations were measured in BD patients before treatment, after 8
weeks of drug treatment, and in control subjects using a sandwich ELISA method.
Before treatment, serum GDNF was significantly lower in BD patients during both manic (
P
<
0.001) and depressive (
P
<
0.001) episodes than in control subjects. From baseline to remission after 8
weeks of treatment, the increase in serum GDNF was statistically significant (
P
<
0.001).
The present study suggests that lower GDNF levels might be involved in the pathophysiology of BD and drug treatment increases the GDNF in BD. |
|---|---|
| AbstractList | Post-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor β family which has been implicated in the pathophysiology of BD. This study aimed to determine whether GDNF in serum was abnormal in BD, and how it responded to drug treatment of BD.
Serum GDNF concentrations were measured in BD patients before treatment, after 8
weeks of drug treatment, and in control subjects using a sandwich ELISA method.
Before treatment, serum GDNF was significantly lower in BD patients during both manic (
P
<
0.001) and depressive (
P
<
0.001) episodes than in control subjects. From baseline to remission after 8
weeks of treatment, the increase in serum GDNF was statistically significant (
P
<
0.001).
The present study suggests that lower GDNF levels might be involved in the pathophysiology of BD and drug treatment increases the GDNF in BD. AbstractObjectivePost-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor β family which has been implicated in the pathophysiology of BD. This study aimed to determine whether GDNF in serum was abnormal in BD, and how it responded to drug treatment of BD. MethodSerum GDNF concentrations were measured in BD patients before treatment, after 8 weeks of drug treatment, and in control subjects using a sandwich ELISA method. ResultsBefore treatment, serum GDNF was significantly lower in BD patients during both manic ( P< 0.001) and depressive ( P< 0.001) episodes than in control subjects. From baseline to remission after 8 weeks of treatment, the increase in serum GDNF was statistically significant ( P< 0.001). ConclusionsThe present study suggests that lower GDNF levels might be involved in the pathophysiology of BD and drug treatment increases the GDNF in BD. Post-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor beta family which has been implicated in the pathophysiology of BD. This study aimed to determine whether GDNF in serum was abnormal in BD, and how it responded to drug treatment of BD. Serum GDNF concentrations were measured in BD patients before treatment, after 8 weeks of drug treatment, and in control subjects using a sandwich ELISA method. Before treatment, serum GDNF was significantly lower in BD patients during both manic (P<0.001) and depressive (P<0.001) episodes than in control subjects. From baseline to remission after 8 weeks of treatment, the increase in serum GDNF was statistically significant (P<0.001). The present study suggests that lower GDNF levels might be involved in the pathophysiology of BD and drug treatment increases the GDNF in BD. Post-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor beta family which has been implicated in the pathophysiology of BD. This study aimed to determine whether GDNF in serum was abnormal in BD, and how it responded to drug treatment of BD.OBJECTIVEPost-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor beta family which has been implicated in the pathophysiology of BD. This study aimed to determine whether GDNF in serum was abnormal in BD, and how it responded to drug treatment of BD.Serum GDNF concentrations were measured in BD patients before treatment, after 8 weeks of drug treatment, and in control subjects using a sandwich ELISA method.METHODSerum GDNF concentrations were measured in BD patients before treatment, after 8 weeks of drug treatment, and in control subjects using a sandwich ELISA method.Before treatment, serum GDNF was significantly lower in BD patients during both manic (P<0.001) and depressive (P<0.001) episodes than in control subjects. From baseline to remission after 8 weeks of treatment, the increase in serum GDNF was statistically significant (P<0.001).RESULTSBefore treatment, serum GDNF was significantly lower in BD patients during both manic (P<0.001) and depressive (P<0.001) episodes than in control subjects. From baseline to remission after 8 weeks of treatment, the increase in serum GDNF was statistically significant (P<0.001).The present study suggests that lower GDNF levels might be involved in the pathophysiology of BD and drug treatment increases the GDNF in BD.CONCLUSIONSThe present study suggests that lower GDNF levels might be involved in the pathophysiology of BD and drug treatment increases the GDNF in BD. Objective Post-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor ^D*b family which has been implicated in the pathophysiology of BD. This study aimed to determine whether GDNF in serum was abnormal in BD, and how it responded to drug treatment of BD. Method Serum GDNF concentrations were measured in BD patients before treatment, after 8 weeks of drug treatment, and in control subjects using a sandwich ELISA method. Results Before treatment, serum GDNF was significantly lower in BD patients during both manic (P < 0.001) and depressive (P < 0.001) episodes than in control subjects. From baseline to remission after 8 weeks of treatment, the increase in serum GDNF was statistically significant (P < 0.001). Conclusions The present study suggests that lower GDNF levels might be involved in the pathophysiology of BD and drug treatment increases the GDNF in BD. [Copyright Elsevier B.V.] |
| Author | Xi, Guangjun Zhang, Xiaobin Zhou, Honghui Xie, Chunming Sha, Weiwei Zhang, Zhijun Zhang, Yumei |
| Author_xml | – sequence: 1 givenname: Xiaobin surname: Zhang fullname: Zhang, Xiaobin email: zhangxiaobim@163.com organization: Department of Psychiatry, Affiliated WuTaiShan Hospital of Yangzhou University, Yangzhou, 225003, PR China – sequence: 2 givenname: Zhijun surname: Zhang fullname: Zhang, Zhijun email: zhijunzhang838@yahoo.com.cn organization: Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, 210009, PR China – sequence: 3 givenname: Weiwei surname: Sha fullname: Sha, Weiwei email: sww63723@sohu.com organization: Department of Psychiatry, Affiliated WuTaiShan Hospital of Yangzhou University, Yangzhou, 225003, PR China – sequence: 4 givenname: Chunming surname: Xie fullname: Xie, Chunming email: chmixe@yahoo.com.cn organization: Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, 210009, PR China – sequence: 5 givenname: Guangjun surname: Xi fullname: Xi, Guangjun email: xiguangjun@163.com organization: Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, 210009, PR China – sequence: 6 givenname: Honghui surname: Zhou fullname: Zhou, Honghui email: zhh8@yzcn.net organization: Department of Psychiatry, Affiliated WuTaiShan Hospital of Yangzhou University, Yangzhou, 225003, PR China – sequence: 7 givenname: Yumei surname: Zhang fullname: Zhang, Yumei email: zhangyumei106106@163.com organization: Department of Psychiatry, Affiliated WuTaiShan Hospital of Yangzhou University, Yangzhou, 225003, PR China |
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| Keywords | Mania Depression Glial cell line-derived neurotrophic factor (GDNF) Bipolar disorder (BD) Mood disorder Glial cell line-derived neurotrophic factor Treatment GDNF Glial cell line derived neurotrophic factor Bipolar disorder |
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| Snippet | Post-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial cell line-derived... AbstractObjectivePost-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial... Objective Post-mortem studies have demonstrated various glial deficits in different brain areas of patients diagnosed with bipolar disorder (BD). Glial cell... |
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| SubjectTerms | Adolescent Adult Adult and adolescent clinical studies Aged Antidepressive Agents - therapeutic use Antipsychotic Agents - therapeutic use Biological and medical sciences Bipolar affective disorder Bipolar disorder (BD) Bipolar Disorder - blood Bipolar Disorder - drug therapy Bipolar Disorder - physiopathology Bipolar disorders Case-Control Studies Depression Drug abuse Enzyme-Linked Immunosorbent Assay Female Glial cell line-derived neurotrophic factor (GDNF) Glial Cell Line-Derived Neurotrophic Factor - blood Glial Cell Line-Derived Neurotrophic Factor - physiology Humans Male Mania Medical sciences Middle Aged Mood disorders Nervous system Pathophysiological aspects Psychiatric/Mental Health Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serum Treatment Young Adult |
| Title | Effect of treatment on serum glial cell line-derived neurotrophic factor in bipolar patients |
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