Bioinformatics analysis of ferroptosis in spinal cord injury

• Published in: Neural regeneration research Vol. 18; no. 3; pp. 626 - 633
• Main Authors: Li, Jin-Ze, Fan, Bao-You, Sun, Tao, Wang, Xiao-Xiong, Li, Jun-Jin, Zhang, Jian-Ping, Gu, Guang-Jin, Shen, Wen-Yuan, Liu, De-Rong, Wei, Zhi-Jian, Feng, Shi-Qing
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.03.2023; Medknow Publications & Media Pvt. Ltd; Shandong University Centre for Orthopedics,Advanced Medical Research Institute,Cheeloo College of Medicine,Shandong University,Jinan,Shandong Province,China; Shandong University Centre for Orthopedics,Advanced Medical Research Institute,Cheeloo College of Medicine,Shandong University,Jinan,Shandong Province,China%InternationalCooperation Base of Spinal Cord Injury,Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics,Tianjin Medical University General Hospital,Tianjin,China; InternationalCooperation Base of Spinal Cord Injury,Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics,Tianjin Medical University General Hospital,Tianjin,China%Department of Orthopedics,Qilu Hospital of Shandong University,Jinan,Shandong Province,China; Department of Orthopedics,Qilu Hospital of Shandong University,Jinan,Shandong Province,China; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Bioinformatics; bioinformatics; drug; ferroptosis; gene ontology enrichment analysis; gene-mirna network; kyoto encyclopedia of genes and genomes pathway; mrna-mirna-lncrna network; progression; spinal cord injury; Ferroptosis; Spinal cord injuries; spinal cord injury; ferroptosis; Kyoto Encyclopedia of Genes and Genomes pathway; mRNA-miRNA-lncRNA network; bioinformatics; progression; Gene Ontology enrichment analysis; drug; gene-miRNA network

Ferroptosis plays a key role in aggravating the progression of spinal cord injury (SCI), but the specific mechanism remains unknown. In this study, we constructed a rat model of T10 SCI using a modified Allen method. We identified 48, 44, and 27 ferroptosis genes that were differentially expressed a...