Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis
Mixed lineage kinase domain‐like (MLKL) is the executioner in the caspase‐independent form of programmed cell death called necroptosis. Receptor‐interacting serine/threonine protein kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomerization, membrane translocation and membrane disruption....
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Published in | The EMBO journal Vol. 40; no. 23; pp. e103718 - n/a |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.12.2021
Blackwell Publishing Ltd John Wiley and Sons Inc |
Subjects | |
Online Access | Get full text |
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