Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis

Mixed lineage kinase domain‐like (MLKL) is the executioner in the caspase‐independent form of programmed cell death called necroptosis. Receptor‐interacting serine/threonine protein kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomerization, membrane translocation and membrane disruption....

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Bibliographic Details
Published inThe EMBO journal Vol. 40; no. 23; pp. e103718 - n/a
Main Authors Liu, Zikou, Dagley, Laura F, Shield‐Artin, Kristy, Young, Samuel N, Bankovacki, Aleksandra, Wang, Xiangyi, Tang, Michelle, Howitt, Jason, Stafford, Che A, Nachbur, Ueli, Fitzgibbon, Cheree, Garnish, Sarah E, Webb, Andrew I, Komander, David, Murphy, James M, Hildebrand, Joanne M, Silke, John
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.12.2021
Blackwell Publishing Ltd
John Wiley and Sons Inc
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