Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells - Miao, Jinhua; Huang, Jiewu; Luo, Congwei; Ye, Huiyun; Ling, Xian; Wu, Qinyu; Shen, Weiwei; Zhou, Lili (Physiological reports, 2021)
Keywords: Aging; Animals; Antibodies; Biotechnology; Catenin; Cell culture; Cellular Senescence - drug effects; Clear cell-type renal cell carcinoma; Creatinine; Disease Models, Animal; Ectopic expression; Epithelial cells; Fibrosis; Humans; Ischemia; Kidney diseases; Kidney Tubules, Proximal - cytology; Kidney Tubules, Proximal - drug effects; Kidney Tubules, Proximal - metabolism; Kidneys; Klotho; Klotho protein; Klotho Proteins - administration & dosage; Klotho Proteins - metabolism; Laboratories; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; mitochondrial dysfunction; Original Research; Physiology; Primary Cell Culture; Proteins; Reactive oxygen species; renal fibrosis; Renal function; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - pathology; Reperfusion; Reperfusion Injury - drug therapy; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Senescence; Wnt protein; Wnt Signaling Pathway - drug effects; Wnt/β‐catenin; Beijing China; United States--US; China; senescence; mitochondrial dysfunction; Klotho; renal fibrosis; Wnt/β-catenin