Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans

• Published in: The Journal of physiology Vol. 592; no. 23; pp. 5317 - 5326
• Main Authors: McNamara, Tanner C., Keen, Jeremy T., Simmons, Grant H., Alexander, Lacy M., Wong, Brett J.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.12.2014; BlackWell Publishing Ltd
• Subjects: Adult; Arginine - analogs & derivatives; Arginine - pharmacology; Body Temperature Regulation - physiology; Enzyme Inhibitors - pharmacology; Exercise - physiology; Heat Stress Disorders - physiopathology; Hemodynamics; Hot Temperature - adverse effects; Humans; Integrative; Male; Microdialysis; NG-Nitroarginine Methyl Ester - pharmacology; Nitric Oxide - physiology; Nitric Oxide Synthase Type I - antagonists & inhibitors; Nitric Oxide Synthase Type I - physiology; Nitric Oxide Synthase Type III - antagonists & inhibitors; Nitric Oxide Synthase Type III - physiology; Ornithine - analogs & derivatives; Ornithine - pharmacology; Oxygen Consumption; Reflex - physiology; Skin - blood supply; Vasodilation - drug effects; Vasodilation - physiology; Young Adult

Key points Increases in skin blood flow and sweating also occur during exercise; however, it is not known if the mechanisms controlling these responses are the same during passive heat stress and exercise. The prevailing thought has been that mechanisms of cutaneous vasodilatation during passive hea...