Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia

• Published in: The Journal of physiology Vol. 575; no. 1; pp. 305 - 315
• Main Authors: Rieu, Isabelle, Balage, Michèle, Sornet, Claire, Giraudet, Christophe, Pujos, Estelle, Grizard, Jean, Mosoni, Laurent, Dardevet, Dominique
• Format: Journal Article
• Language: English
• Published: Oxford, UK The Physiological Society 15.08.2006; Blackwell Publishing Ltd; Blackwell Science Inc
• Subjects: Aged; Amino Acids - administration & dosage; Amino Acids - pharmacokinetics; Breath Tests; Carbon Dioxide - metabolism; Carbon Radioisotopes; Dietary Supplements; Humans; Insulin - blood; Integrative; Leucine - administration & dosage; Leucine - pharmacokinetics; Male; Muscle Proteins - biosynthesis; Muscle, Skeletal - metabolism; Phenylalanine - pharmacokinetics; Postprandial Period

The present study was designed to assess the effects of dietary leucine supplementation on muscle protein synthesis and whole body protein kinetics in elderly individuals. Twenty healthy male subjects (70 ± 1 years) were studied before and after continuous ingestion of a complete balanced diet supp...