Bayesian Approach to Dose-Response Assessment and Synergy and Its Application to In Vitro Dose-Response Studies

• Published in: Biometrics Vol. 66; no. 4; pp. 1275 - 1283
• Main Authors: Hennessey, Violeta G, Rosner, Gary L, Bast, Robert C. Jr, Chen, Min-Yu
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.12.2010; Wiley-Blackwell; Blackwell Publishing Ltd
• Subjects: Additivity; Antineoplastic Agents - pharmacology; Bayes Theorem; Bayesian analysis; BIOMETRIC PRACTICE; Cell lines; Combination index method; Confidence interval; Dosage; Dose response relationship; Dose-Response Relationship, Drug; Drug dosages; Drug interaction; Drug interactions; Drug Synergism; Drug synergy; E max model; Estimation bias; Female; Humans; Inference; Inhibitory Concentration 50; Interaction index; Loewe additivity model; Markov Chains; Median-effect principle; Medical research; Monte Carlo Method; Ovarian cancer; Ovarian Neoplasms - drug therapy; Regression analysis

Summary In this article, we propose a Bayesian approach to dose-response assessment and the assessment of synergy between two combined agents. We consider the case of an in vitro ovarian cancer research study aimed at investigating the antiproliferative activities of four agents, alone and paired, i...