Stress hyperglycemia, cardiac glucotoxicity, and critically ill patient outcomes current clinical and pathophysiological evidence

• Published in: Physiological reports Vol. 9; no. 2; pp. e14713 - n/a
• Main Authors: Scheen, Marc, Giraud, Raphael, Bendjelid, Karim
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2021; John Wiley and Sons Inc; Wiley
• Subjects: Acute coronary syndromes; Animals; Blood glucose; cardiogenic shock; Cardiovascular Diseases - etiology; Cardiovascular Diseases - pathology; Catecholamines; Congestive heart failure; Critical Illness; Diabetes; Glucagon; Glucose; Glucose - metabolism; Glucose Intolerance - etiology; Glucose Intolerance - metabolism; Glucose Intolerance - pathology; Glucose tolerance; glucotoxicity; Glycogen; heart; Heart attacks; Heart failure; Homeostasis; Humans; Hyperglycemia; Hyperglycemia - etiology; Hyperglycemia - metabolism; Hyperglycemia - pathology; Illnesses; Insulin; Insulin Resistance; Kinases; Medical prognosis; Metabolism; Mitochondria; Mortality; Oxidative Stress; Patients; Physiology; Review; Reviews; Steroid hormones; stress hyperglycemia; Trends; heart failure; stress hyperglycemia; cardiogenic shock; glucotoxicity; insulin; heart
• ISSN: 2051-817X; 2051-817X
• DOI: 10.14814/phy2.14713

Stress hyperglycemia is a transient increase in blood glucose during acute physiological stress in the absence of glucose homeostasis dysfunction. Its's presence has been described in critically ill patients who are subject to many physiological insults. In this regard, hyperglycemia and impair...