Molecular Controls of Lymphatic VEGFR3 Signaling

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 35; no. 2; pp. 421 - 429
• Main Authors: Deng, Yong, Zhang, Xi, Simons, Michael
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.02.2015
• Subjects: Cell Movement; Cells, Cultured; Endocytosis; Endothelial Cells - metabolism; Enzyme Activation; Humans; Kinetics; Ligands; Lymphangiogenesis; Lymphatic Vessels - metabolism; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - metabolism; Neuropilin-1 - genetics; Neuropilin-1 - metabolism; Neuropilin-2 - genetics; Neuropilin-2 - metabolism; Protein Multimerization; Proto-Oncogene Proteins c-akt - metabolism; Receptor-Like Protein Tyrosine Phosphatases, Class 3 - metabolism; RNA Interference; Signal Transduction; Transfection; Vascular Endothelial Growth Factor A - metabolism; Vascular Endothelial Growth Factor C - metabolism; Vascular Endothelial Growth Factor Receptor-2 - metabolism; Vascular Endothelial Growth Factor Receptor-3 - genetics; Vascular Endothelial Growth Factor Receptor-3 - metabolism; VEGFR2; NRP1; VEGFR3; NRP2; VEGF-C; VE-PTP

OBJECTIVES—Vascular endothelial growth factor receptor 3 (VEGFR3) plays important roles both in lymphangiogenesis and angiogenesis. On stimulation by its ligand VEGF-C, VEGFR3 is able to form both homodimers as well as heterodimers with VEGFR2 and activates several downstream signal pathways, includ...