A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin

• Published in: Nature communications Vol. 13; no. 1; pp. 6361 - 11
• Main Authors: Zhang, Hongjiao, Li, Zixin, Zhou, Shuang, Li, Shu-Ming, Ran, Huomiao, Song, Zili, Yu, Tao, Yin, Wen-Bing
• Format: Journal Article Web Resource
• Language: English
• Published: London Nature Publishing Group UK 26.10.2022; Nature Publishing Group; Nature Research; Nature Portfolio
• Subjects: 101/58; 38/22; 38/44; 38/77; 38/90; 45/88; 631/326/2522; 631/61/318; 631/92/173; 82/80; 82/83; Adenylation; Agriculture & agronomie; Agriculture & agronomy; Bacteria; Biochemistry, Genetics and Molecular Biology (all); Biosynthesis; Catalysis; Chemistry (all); Coumaric acid; Elongation; Flavonoids; Fungi; Homology; Humanities and Social Sciences; Life sciences; Malonyl Coenzyme A; multidisciplinary; Naringenin; non-ribosomal peptide synthase; p-Coumaric acid; p-Hydroxybenzoic acid; Peptide Synthases; Peptide Synthases - metabolism; Peptides; Phylogeny; Physics and Astronomy (all); Polyketide synthase; Polyketide Synthases; Polyketide Synthases - genetics; Polyketide Synthases - metabolism; Science; Science (multidisciplinary); Sciences du vivant; Substrates; Tandem Mass Spectrometry; Yeast

Biosynthesis of the flavonoid naringenin in plants and bacteria is commonly catalysed by a type III polyketide synthase (PKS) using one p -coumaroyl-CoA and three malonyl-CoA molecules as substrates. Here, we report a fungal non-ribosomal peptide synthetase -polyketide synthase (NRPS-PKS) hybrid Fns...