In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

• Published in: EJNMMI research Vol. 10; no. 1; p. 116
• Main Authors: Joo, Yo-Han, Kim, Yun-Kwan, Choi, In-Gyu, Kim, Hyeon-Jin, Son, Young-Don, Kim, Hang-Keun, Cumming, Paul, Kim, Jong-Hoon
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 02.10.2020; Springer Nature B.V; SpringerOpen
• Subjects: Ablation; Brain; Cardiac Imaging; Emission analysis; FDG; Glucose; Glutamate; Imaging; Knockout; Magnetic resonance spectroscopy; Measurement methods; Medical imaging; Medicine; Medicine & Public Health; Metabolism; mGluR5; Neuroimaging; NMDA; Nuclear Medicine; Oncology; Original Research; Orthopedics; PET; Positron emission; Radiology; Receptors; Rodents; Schizophrenia; NMDA; FDG; Glutamate; mGluR5; Knockout; PET; MRS

Background Perturbed functional coupling between the metabotropic glutamate receptor-5 (mGluR5) and N-methyl- d -aspartate (NMDA) receptor-mediated excitatory glutamatergic neurotransmission may contribute to the pathophysiology of psychiatric disorders such as schizophrenia. We aimed to establish t...