In vitro-in vivo Extrapolation of Transporter-mediated Clearance in the Liver and Kidney

• Published in: DRUG METABOLISM AND PHARMACOKINETICS Vol. 24; no. 1; pp. 37 - 52
• Main Authors: Kusuhara, Hiroyuki, Sugiyama, Yuichi
• Format: Journal Article
• Language: English; Japanese
• Published: England Elsevier Ltd 01.01.2009; Japanese Society for the Study of Xenobiotics
• Subjects: Animals; Biological Transport; Blood-Brain Barrier - metabolism; Carrier Proteins - metabolism; Carrier Proteins - physiology; hepatic elimination; hepatocytes; Humans; in vitro-in vivo extrapolation; Inactivation, Metabolic; Kidney - metabolism; kidney slices; Liver - metabolism; Models, Biological; Pharmaceutical Preparations - metabolism; Pravastatin - blood; Pravastatin - pharmacokinetics; Predictive Value of Tests; Tissue Distribution; tubular secretion; Xenobiotics - blood; Xenobiotics - pharmacokinetics; BCRP; OCT; ABC; BBB; OAT; MATE; IVIVE; tubular secretion; MRP; OATP; SLC; hepatocytes; AUC; in vitro-in vivo extrapolation; TMSX; MPPF; hepatic elimination; kidney slices

Transporter govern drug movement into and out of tissues, thereby playing an important role in drug disposition in plasma and to the site of action. The molecular cloning of such transporters has clarified the importance of members of the solute carrier family, such as OATP/SLCO, OCT/SLC22, OAT/SLC2...