Evaluation of Strategies for Reducing Vancomycin-Piperacillin/Tazobactam Incompatibility

• Published in: Pharmaceutics Vol. 15; no. 8; p. 2069
• Main Authors: Martin Mena, Anthony, Négrier, Laura, Treizebré, Anthony, Guilbert, Marie, Bonnaire, Lucille, Daniau, Valentine, Leba Bonki, Gabie, Odou, Pascal, Genay, Stéphanie, Décaudin, Bertrand
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2023; MDPI
• Series: Advances in Parenteral Formulations
• Subjects: Air pollution; Air quality management; Antibiotics; Comparative analysis; drug incompatibility; Drugs; Hydration; in-line filter; infusion; Intensive care; Life Sciences; particulate load; Pharmaceutical sciences; Pharmacology; piperacillin/tazobactam; Tazobactam; Vancomycin; France; Germany; particulate load; vancomycin; piperacillin/tazobactam; drug incompatibility; in-line filter; infusion

Background: Drug incompatibility is defined as a physical-chemical reaction between two or more injectable drugs and that results mainly in precipitation or insolubility. Several strategies for reducing incompatibilities have been implemented empirically in intensive care units. However, these strat...