Effect of imbalance and intracluster correlation coefficient in cluster randomization trials with binary outcomes when the available number of clusters is fixed in advance

• Published in: Contemporary clinical trials Vol. 30; no. 4; pp. 317 - 320
• Main Authors: Ahn, Chul, Hu, Fan, Skinner, Celette Sugg, Ahn, Daniel
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2009; Elsevier
• Subjects: Binary outcomes; Biological and medical sciences; Cardiovascular; Clinical trial. Drug monitoring; Cluster Analysis; Computerized, statistical medical data processing and models in biomedicine; Data Interpretation, Statistical; Epidemiology; General aspects; General pharmacology; Hematology, Oncology and Palliative Medicine; Humans; Intracluster correlation; Medical sciences; Medical statistics; Methodology; Models, Statistical; Pharmacology. Drug treatments; Public health. Hygiene; Public health. Hygiene-occupational medicine; Randomized Controlled Trials as Topic - methods; sample size; Varying cluster size; Intracluster correlation; Varying cluster size; sample size; Binary outcomes; Correlation coefficient; Correlation; Randomization; Statistical analysis; Prognosis; Sample size; Clinical trial; Cluster

In some cluster randomization trials, the number of clusters cannot exceed a specified maximum value due to cost constraints or other practical reasons. Donner and Klar [Donner A, and Klar N. Design and analysis of cluster randomization trials in health research. Oxford University Press 2000] provid...